Chronic reduction of store operated Ca²⁺ entry is viable therapeutically but is associated with cardiovascular complications حسب Fang Yu (156838)

"…They further establish the SOCE hypomorph line as a genetic model to define the therapeutic window of SOCE inhibition and dissect toxicities associated with chronic SOCE inhibition in a tissue-specific fashion.…"

Breaking the barriers towards large-scale microalgae-based bio-hydrogen production حسب Isra Koko (22631396)

"…Results showed that cultivation dominates the process cost: typical biomass costs are $3.54–$5.78/kg in tubular PBRs versus $3.42–$4.13/kg in ORPs; an automation/modularization case decreased microalgae production cost from $89 to $16/kg at ∼200 t/yr. …"

Spatial, temporal, and demographic patterns in prevalence of smoking tobacco use and attributable disease burden in 204 countries and territories, 1990–2019: a systematic analysis... حسب Marissa B Reitsma (8674341)

"…Although prevalence of smoking had decreased significantly since 1990 among both males (27·5% [26·5–28·5] reduction) and females (37·7% [35·4–39·9] reduction) aged 15 years and older, population growth has led to a significant increase in the total number of smokers from 0·99 billion (0·98–1·00) in 1990. …"

3D FEM Model on the Parameters’ Influence of EPB-TBM on Settlements of Single and Twin Metro Tunnels During Construction حسب Masoud Forsat (14158980)

"…<p>The present research exposes the investigation on three-dimensional modeling of the single and twin metro tunnels for the case of the Tehran metro line. At first, simulation implemented on the comparison of the ground movements in the single and twin tunnels. …"

miRNA-dependent regulation of STIM1 expression in breast cancer حسب Rashmi P. Kulkarni (18618634)

"…Consistently, overexpression of Ago2 results in decreased STIM1 protein levels in MDA-MB-231 cells. …"

Post-transcriptional regulation of Pabpn1 by the RNA binding protein HuR حسب Brittany L Phillips (18696937)

"…However, no studies have defined the mechanisms that regulate Pabpn1 expression. …"

The cost associated with the development of the antimicrobial stewardship program in the adult general medicine setting in Qatar حسب Dina Abushanab (10696501)

"…May 2015-April 2016), and developed ASP was defined as the last 12 months of a 5-year ASP implementation in Hamad Medical Corporation (HMC) (i.e. …"

On the Performance of the Node Control Volume Finite Element Method for Modeling Multi-phase Fluid Flow in Heterogeneous Porous Media حسب Abdul Salam Abd (14151648)

"…Material properties are defined on elements, while transport is simulated on the control volumes. …"

Preterm birth in low-middle income Countries حسب Alim, Swarray-Deen

"…Although the overall trend is decreasing, this is mainly in high-income countries (HIC). …"
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Cost-benefit analysis of antimicrobial stewardship program in a cancer setting in Qatar حسب Dina Abushanab (10696501)

"…Cost avoidance was the expenses saved due to decreased hospital stays and fewer adverse drug events (ADEs). …"

Channel Network Control on Seasonal Lake Area Dynamics in Arctic Deltas حسب Tejedor, Alejandro

"…This shrinkage signal, easily extracted from remote sensing observations, may offer the means to constrain estimates of lacustrine methane emissions and to develop process-based estimates of depth to permafrost on arctic deltas.…"
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Global fertility in 204 countries and territories, 1950–2021, with forecasts to 2100: a comprehensive demographic analysis for the Global Burden of Disease Study 2021 حسب Natalia V, Bhattacharjee

"…The number of countries and territories with fertility rates remaining above replacement was forecast to be 49 (24·0%) in 2050 and only six (2·9%) in 2100, with three of these six countries included in the 2021 World Bank-defined low-income group, all located in the GBD super-region of sub-Saharan Africa. …"
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Resilience-uncertainty nexus in building energy management integrated with solar system and battery storage حسب Hasan Mehrjerdi (16869957)

"…The energy resilience is improved and the energy cost is decreased at the same time while all events and uncertainties are modeled. …"

Global time differences in road traffic injuries among children and adolescents between and 1990 and 2013: Regional and economical perspectives from global burden of diseases study حسب Uzma Rahim Khan (19794408)

"…<p dir="ltr">In 2010, road traffic injuries (RTIs) are the leading cause of deaths in those aged 1-19 years globally and half of those victims are vulnerable road users (VRUs), defined as pedestrians, bicyclists and motorcyclists. …"

Comparing the Performance of a Straight-Channel Heat Sink with Different Channel Heights: An Experimental and Numerical Study حسب Mahsa Hajialibabaei (19437967)

"…This study aims to enhance the thermal performance of a straight-channel heat sink while decreasing the pressure drop. In this design, the height of inside channels is reduced to provide open space above the channel while the size of the heat sink remains constant. …"

Effect of AlN nanoparticle concentration in the electrolyte on corrosion resistance and mechanical properties of the electrodeposited composite coatings حسب Khan, M.S.

"…The impact of corrosion is widespread, affecting structures, equipment, and infrastructure across various industries increasing the maintenance cost and thereby decreasing profit and efficiency. Nickel-based coatings are one of the most tempting options owing to their enhanced mechanical and corrosion-resistant properties. …"
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LDL-C Targets in Secondary Prevention: How Low Should We Go? حسب Karim Bayoumy (3496688)

"…The concern for adverse effects with very low LDL-C levels is not backed by the literature, and side effects appear to be medication-specific. There still remains a question of the cost-effectiveness of some non-statin therapies particularly PCSK9 inhibitors, in spite of recent price decreases, and whether the benefit is worth the cost.…"

The molecular mechanisms of apoptosis accompanied with the epigenetic regulation of the NY-ESO-1 antigen in non-small lung cancer cells treated with decitabine (5-aza-CdR) حسب Varghese P. Inchakalody (14557382)

"…Therefore, we investigated the molecular mechanisms accompanied with the epigenetic regulation of NY-ESO-1 in 5-Aza-CdR-treated NCI–H1975 cell line. We showed significant induction of the NY-ESO-1 protein (**p < 0.0097) using Cellular ELISA. …"

STIM1 signals through NFAT1 independently of Orai1 and SOCE to regulate breast cancer cell migration حسب Ayat S. Hammad (9592374)

"…SOCE has been shown to be important for breast cancer cell migration where knockdown of SOCE components (STIM1 or Orai1) decreases cancer metastasis. Here we show unexpectedly that complete knockout of STIM1 (STIM1-KO) using gene editing in metastatic MDA-MB-231 breast cancer cells results in faster migration and enhanced invasion capacity. …"

An Experimental Investigation of the Effects of Dressing and Grinding Parameters on Sustainable Grinding of Inconel 738 Used for Automated Manufacturing حسب Mohammadjafar Hadad (17541345)

"…With multipoint diamond tools, the grinding performance during the life of the dressing tool also tends to remain more consistent, which is a definite advantage in automated production. …"