Long non-coding RNA MALAT1 promotes steatosis in HepG2 cells by modulating target gene expression in presence of Exendin-4 حسب Olfa Khalifa (10914452)

"…Furthermore, confocal microscopy analysis of BODIPY-stained untreated, steatotic, and Ex-4-treated steatotic cells showed that Ex-4 significantly decreases the number of lipid droplets. Fatty acid uptake and transport genes were also affected by MALAT1 knockdown. …"

Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in age-related hearing loss حسب Meritxell Espino Guarch (18810097)

Investigating the structural impacts of a novel missense variant identified with whole exome sequencing in an Egyptian patient with propionic acidemia حسب Ali Zaki Ibrahim (17092957)

"…<p dir="ltr">Propionic Acidemia (PA) is an inborn error of metabolism caused by variants in the PCCA or PCCB genes, leading to mitochondrial accumulation of propionyl-CoA and its by-products. …"

Technical assessment of different extraction methods and transcriptome profiling of RNA isolated from small volumes of blood حسب Mahesh Kumar Reddy Kalikiri (17886695)

"…The TURBO DNA Free treatment affected the RNA samples negatively, decreasing the RNA yield and reducing the quality and reproducibility of the transcriptomic data. …"

Therapeutic targeting of the TPX2/TTK network in colorectal cancer حسب Hibah Shaath (5599658)

"…<h3>Background</h3><p dir="ltr">While the increased screening, changes in lifestyle, and recent advances in treatment regimen have decreased colorectal cancer (CRC) mortality, metastatic disease and recurrence remains a major clinical challenge. …"

Role of intravitreal antivascular endothelial growth factor injections for choroidal neovascularization due to choroidal osteoma حسب Mansour, Ahmad M.

"…By paired comparison, mean decrease from baseline was 119.7 microns at 6 months (n = 15; P = 0.001 ), 105.3 microns at 1 year (n = 10; P = 0.03 ), and 157.6 microns at 2 years (n = 7;p = 0.08 ). …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Modulation of SLFN11 induces changes in DNA Damage response in breast cancer حسب Christophe Michel Raynaud (17449906)

"…The use of a CRISPR-dCas9 UNISAM and KRAB system could increase or decrease SLFN11 expression significantly (up to fivefold), stably and specifically in BT-549 and T47D cancer cell lines. …"

BCL-2 Inhibitor Venetoclax Induces Autophagy-Associated Cell Death, Cell Cycle Arrest, and Apoptosis in Human Breast Cancer Cells حسب Ali Alhoshani (3720718)

"…</p><h3>Results</h3><p dir="ltr">Treatment of human breast cancer cells with increasing concentrations of VCX caused a significant decrease in cells growth and proliferation. This effect was associated with a significant increase in the percentage of apoptotic MDA-MB-231 cells and in the expression of the apoptotic genes, caspase 3, caspase 7, and BAX, with inhibition of antiapoptotic gene, BCL-2 levels. …"

Aqueous urtica dioica leaves extract inhibits proliferation of acute myeloid leukemia cells in vitro حسب Rizk, Sandra

"…The decrease was more significant after 72hr with an IC50 at 16mg/ml. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Rhus coriaria L. (Sumac) Demonstrates Oncostatic Activity in the Therapeutic and Preventive Model of Breast Carcinoma حسب Peter Kubatka (11008854)

"…Finally, only in lower sumac dose, significant decreases in methylation status of three out of five gene promoters–ATM, PTEN, and TIMP3 (PITX2 and RASSF1 promoters were not changed). …"

Deletion of <i>RFX6</i> impairs iPSC-derived islet organoid development and survival, with no impact on PDX1⁺/NKX6.1⁺ progenitors حسب Noura Aldous (15429873)

"…Furthermore, induced pluripotent stem cell (iPSC) lines lacking RFX6 were generated using CRISPR/Cas9. …"

Induction of Resistance to Fluconazole and Caspofungin in Candida glabrata Followed by Phenotypic and Genotypic Characterization حسب Chedraoui, Christy Antonios

"…The majority of mutations were found in genes implicated in adhesion, such as in the AWP, PWP, and EPA family of genes, which might explain the observed decrease in adhesion. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Genetic Deletion of DNAJB3 Using CRISPR-Cas9, Produced Discordant Phenotypes حسب Shadi Nejat (19457212)

"…Similarly, KO 47 mice also showed a slower rate of glucose clearance in GTT that was consistent with decreased mRNA expression of the GLUT4 gene in WAT but not in the muscle. …"

Studies of Glyoxalase 1-Linked Multidrug Resistance Reveal Glycolysis-Derived Reactive Metabolite, Methylglyoxal, Is a Common Contributor in Cancer Chemotherapy Targeting the Splic... حسب Muhanad Alhujaily (11630107)

"…Spliceosomal proteins were targets of MG modification. Spliceosomal gene expression correlated positively with Glo1 in human tumor cell lines and tumors. …"

Comparative Effect of Sodium Butyrate and Sodium Propionate on Ovarian Cancer Migration, Invasion, and Epithelial-To-Mesenchymal Transition حسب Sleem, Reem

"…Methodology: The two ovarian cancer cell lines, SKOV-3 and PA-1, were treated with NaB and NaP for 24h. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Cytotoxicity of [HuArgI (co)-PEG5000]-induced arginine deprivation to ovarian Cancer cells is autophagy dependent حسب Nasreddine, Ghenwa

"…Addition of excess L-citrulline rescued only one of three cell lines tested, indicating that the majority of cell lines are completely auxotrophic for arginine. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Targeting arginine auxotrophy in pancreatic cancer cells using human recombinant arginase I-induced arginine deprivation. (c2017) حسب Khalil, Nathalie

"…In this study, we examined the mechanisms of arginine auxotrophy in PC cell lines. Sensitivity to arginine depletion using HuArgI (Co)-PEG5000 was evident in all of the tested PC cell lines with IC50 values in the pM range at 72 hours following treatment. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

1787 evaluation of transperineal prostatic administration of a PSA-activasted protoxin (PRX302) in men with luts secondary to BPH حسب Elhilali, Mostafa

"…In the Phase I study, mean IPSS showed a decrease of 6.5 points (34%), mean QoL a decrease of 2 points (44%) and mean prostate volume a decrease of 5.5 cc (13%) at 12-months compared to screening. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Daucus carota pentane/diethyl ether fraction inhibits motility and reduces invasion of cancer cells حسب Zgheib, Perla

"…Upon treatment, a pronounced decrease in cancer cell motility was observed in the 4 cell lines. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Alterations in Beta Cell Identity in Type 1 and Type 2 Diabetes حسب Abu Saleh Md Moin (6189512)

"…Dedifferentiation is well characterized by the decrease in expression of key β cell markers such as genes encoding major transcription factors, e.g., MafA, NeuroD1, Nkx6.1, and Foxo1, and an increase in atypical or “disallowed” genes for β cells such as lactate dehydrogenase, monocarboxylate transporter MCT1, or progenitor cell genes (Neurog3, Pax4, or Sox9). …"