Neosetophomone B induces apoptosis in multiple myeloma cells via targeting of AKT/SKP2 signaling pathway by Shilpa Kuttikrishnan (3520079)

“…Our study investigated NSP‐B's antitumor effects on MM cell lines (U266 and RPMI8226) and the involved molecular mechanisms. …”

Dexamethasone Promotes a Stem-Like Phenotype in Human Melanoma Cells <i>via</i> Tryptophan 2,3 Dioxygenase by Marta Cecchi (21363581)

“…Moreover, dex stimulates spherogenesis of both cell lines, which is mediated by TDO, evident by its suppression with 680C91, a TDO inhibitor. …”

Evaluation of Estrone Liposomes using Microfluidics for Breast Cancer Therapy by Al Bostami, Rouba D.

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Electric Grid Resilience Enhancement During Natural Disasters: An Optimization-Based UAV Inspection and Dynamic Crew Dispatch Model by Serag, Yousef

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Writing and publishing language studies in the Arab region [Khitabaat Journal] by Emad Abdul-latif (21841985)

“…Klein starts from an implicit assumption that writing and reading are individual activities and suggests that (individual) writers must decrease their production to enable their (individual) readers to read it. …”

Grid electricity demand reduction through applying passive and active strategies for a house in Baghdad, Iraq by Al-Badri, Nadia Rashid

“…By adopting 1Pearl, it provided 4.33% energy reduction while 2 Pearls can achieve about 4.37% decrease in energy. This means that roof insulation should take priority when considering the passive solutions for conserving energy. …”
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Differential water quality in confined and free-flowing water bodies, Lebanon by Korfali, Samira Ibrahim

“…This emphasises the importance of assessing surface water quality as a projected means to increase water availability. This study involves two different water bodies, the freely flowing Nahr-Ibrahin River and the Qaraaoun Reservoir, an impoundment of the Litani River. …”
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Brain Connectivity Analysis Under Semantic Vigilance and Enhanced Mental States by Yahya, Fares

“…The quantification of mental states was performed by means of statistical analysis of indexes based on GTA, behavioral responses of time-on-task (TOT), and Brunel Mood Scale (BRMUS). …”
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Testing and Evaluation of a Smart Irrigation System towards Smart landscaping in UAE by ALSULAIMANI, FATMA

“…The outcomes of the use of SMS have shown a better results in water conservation and a decrease in water flow in the month of September by 21% and 26% in October. …”
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A framework for implementing Green Supply Chain Management: The Case of Petco Gulf by HASSAN, HUDA YOUSIF ALI AHMED

“…From this research, it was found that as Petco gulf is present in the U.A.E. it can take advantage of this and by applying the GSCM strategies against each of its components this will help the company by, increased overall gross profit with the decrease in cost since going green in its supply chain means reducing the overheads. …”
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A novel inhibitor of STAT3 activation is efficacious against established central nervous system melanoma and inhibits regulatory T cells by Abou-Ghazal, Mohamed K.

“…Results WP1066 achieved an IC50 of 1.6 μM, 2.3 μM, and 1.5 μM against melanoma cell line A375, B16 and B16EGFRvIII, respectively. WP1066 suppressed the phosphorylation of JAK2 and STAT3 (Tyr705) in these cells. …”
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A novel inhibitor of signal transducers and activators of transcription 3 activation is efficacious against established central nervous system melanoma and inhibits regulatory T ce... by Abou-Ghazal, Mohamed

“…Experimental Design: The antitumor activities and related mechanisms of WP1066 were investigated both in vitro on melanoma cell lines and in vivo on mice with subcutaneously syngeneic melanoma or with intracerebral melanoma tumors. …”
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Tumor protease-activated fusion toxins by Abi-Habib, Ralph J.

“…In this study, we demonstrate that DTU2GMCSF is highly potent against AML cell lines in vitro and is not toxic to normal cells both in vitro and in vivo. …”
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Selective induction of apoptosis in T-cell acute lymphoblastic leukemia by pristimerin through dual PI3K/AKT pathway inhibition and ROS generation by Shilpa Kuttikrishnan (3520079)

“…Prist significantly increases reactive oxygen species (ROS) levels and depletes glutathione (GSH), leading to mitochondrial dysfunction and cytochrome c release. …”

Protein arginine methyltransferase 5 (PRMT5) activates WNT/β‐catenin signalling in breast cancer cells via epigenetic silencing of DKK1 and DKK3 by Harshita Shailesh (14779408)

“…<p></p><div> <p>Protein arginine methyltransferase 5 (PRMT5) activity is dysregulated in many aggressive cancers and its enhanced levels are associated with increased tumour growth and survival. However, the role of PRMT5 in breast cancer remains underexplored. …”

Inositol 1,4,5-Trisphosphate Receptors in Hypertension by Ali H. Eid (5461829)

“…This involves a phenotypic switch of VSMCs as well as an alteration of cytoplasmic Ca²⁺ signaling machinery, a phenomena tightly related to the aging process. Several lines of evidence implicate changes in expression/function levels of IP₃R isoforms in the development of hypertension, VSMC phenotypic switch, and vascular aging. …”

Sanguinarine mediated apoptosis in Non-Small Cell Lung Cancer via generation of reactive oxygen species and suppression of JAK/STAT pathway by Kirti.S. Prabhu (17191231)

“…SNG treatment increased Bax/Bcl-2 ratio, which contributed to a leaky mitochondrial membrane leading to cytochrome c release accompanied by caspase activation. …”

Cardiorespiratory Fitness and Performance Adaptations to High-Intensity Interval Training: Are There Differences Between Men and Women? A Systematic Review with Meta-Analyses by Merilyn Lock (9440240)

“…Data were sub-grouped for men and women, baseline training level, mean age, intervention type, and intervention length. …”

Dietary Calcium Intake of 1200 mg/d May Have Negative Correlation on Percent Body Fat by Dimassi, Hani I.

“…The high-calcium group (intake ≥1200 mg/d) had a significantly higher mean caloric intake (P ≤ .01) and significantly lower percent body fat (P ≤ .05) than the low-calcium group (intake <1200 mg/d). …”
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Ultrasound‑triggered herceptin liposomes for breast cancer therapy by Elamir, Amal

“…Exposing the liposomes to low-frequency ultrasound (LFUS) triggered drug release which increased with the increase in power density. Trastuzumab conjugation resulted in enhancing the sensitivity of the liposomes to LFUS. …”
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