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Synergistic Effect of Epigenetic Inhibitors Decitabine and Suberoylanilide Hydroxamic Acid on Colorectal Cancer In vitro
Published 2019“…The accumulation of aberrant DNA methylation and histone acetylation plays a major role in altering gene activity and driving tumor onset, progression and metastasis. …”
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Depression, anxiety and obsessive–compulsive symptoms in relation to nutritional status and outcome in severe anorexia nervosa
Published 2012“…The present study among severe AN patients investigates links between these psychological variants and nutritional status at admission and subsequent to nutritional rehabilitation. …”
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204
The Impact of a Computerized Potassium Alert on Adverse Drug Events and Pharmacists' Interventions
Published 2010“…Conclusions: Implementation of a computerized pharmacy alert resulted in a statistically significant decrease in adverse drug events related to hyperkalemia in our institution. …”
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205
Efficacy And Safety of Cannabidiol on Juvenile Diabetes Outcomes in Male Rats
Published 2023“…CBD presents desirable effects on hyperglycemia by protecting against oxidative stress and inflammation, having neuroprotective properties, and acting on receptors linked to glycemia. Thus, CBD has the potential to decrease HbA1C in diabetic patients (Diabetes Mellitus type 1) and improve their lives. …”
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206
Polyaniline/Polystyrene Blends: In-Depth Analysis of the Effect of Sulfonic Acid Dopant Concentration on AC Conductivity Using Broadband Dielectric Spectroscopy
Published 2018“…The conductivity is discussed in terms of changes in the dielectric permittivity storage <em>(ɛʼ)</em>, loss <em>(ɛʼʼ)</em>, and modulus <em>(Mʼʼ)</em> of the blends over a wide range of temperatures. This is linked to the glass transition temperature of the PANI. …”
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207
Driving simulation sickness and the sense of presence: Correlation and contributing factors
Published 2021“…Importantly, designing buildings that replicate a real-world environment could increase SP and decrease SS. Moreover, designing high quality and resolution scenarios could also increase SP, thus decreasing the severity of SS symptoms. …”
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208
Direct assembly process
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Performance analysis of a small-scale Orthopter-type Vertical Axis Wind Turbine
Published 2018“…Increasing solidity was achieved by either decreasing the blade aspect ratio or increasing the number of blades, both resulting in a higher peak power coefficient (Cp,max) of the VAWT. …”
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211
Predictive Power of Random Forests in Analyzing Risk Management in Islamic Banking
Published 2024“…Findings reveal that larger banks provide more consistent survey responses, driven by their confidence and larger survey budgets. Moreover, a positive link is established between a country’s development, characterized by high GDPs and low inflation and interest rates, and the precision of Islamic banks’ survey responses. …”
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Caloric restriction reduces trabecular bone loss during aging and improves bone marrow adipocyte endocrine function in male mice
Published 2024“…Cortical bone, however, was decreased in young mice on CR and remained reduced in aged mice, irrespective of dietary intervention. …”
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214
Past and future climate effects on population structure and diversity of North Pacific surfgrasses
Published 2024“…</p><h3>Main Conclusions</h3><p dir="ltr">The genetic patterns observed in the present reveal the influence of climate‐driven range shifts in the past and suggest further consequences of climate change in the future, with potential loss of unique gene pools. This study also shows that investigating climate links to present genetic information at multiple timescales can establish a historical context for analyses of the future evolutionary history of populations.…”
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Novel thiazolones for the simultaneous modulation of PPARγ, COX-2 and 15-LOX to address metabolic disease-associated portal inflammation
Published 2025“…Compound 2a activated PPARγ with an EC50 value of 3.4 μM in a Gal4-hybrid reporter gene assay, indicating partial agonistic action. …”
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216
Whole-Genome Molecular Characterization and Typing of Staphylococcus aureus Isolated from Lebanon
Published 2020“…The worldwide dissemination of the MRSA-ST80 clone decreased over the past few years, but it was still the most common strain in Lebanon. …”
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217
Drug Resistance Induction and Phenotypic and Genotypic Characterization of a Candida albicans Drug Sensitive Isolate
Published 2023“…In the ALS4 gene for example, we observed 2 mutations in the susceptible strain and 5 mutations in the resistant strain. …”
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218
Positive regulation of oxidative phosphorylation by nuclear myosin 1 protects cells from metabolic reprogramming and tumorigenesis in mice
Published 2023“…These changes are associated with reduced OXPHOS gene expression, decreased mitochondrial DNA copy number, and deregulated mitochondrial dynamics, which lead to metabolic reprogramming of NM1 KO cells from OXPHOS to aerobic glycolysis.This, in turn, is associated with a metabolomic profile typical for cancer cells, namely increased amino acid-, fatty acid-, and sugar metabolism, and increased glucose uptake, lactate production, and intracellular acidity. …”
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STIM1 signals through NFAT1 independently of Orai1 and SOCE to regulate breast cancer cell migration
Published 2023“…SOCE has been shown to be important for breast cancer cell migration where knockdown of SOCE components (STIM1 or Orai1) decreases cancer metastasis. Here we show unexpectedly that complete knockout of STIM1 (STIM1-KO) using gene editing in metastatic MDA-MB-231 breast cancer cells results in faster migration and enhanced invasion capacity. …”
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Blockchain, climate damage, and death: Policy interventions to reduce the carbon emissions, mortality, and net-zero implications of non-fungible tokens and Bitcoin
Published 2022“…</p><p dir="ltr">Nonetheless, many popular types of blockchain have resisted the pressure to decrease their environmental impact, including Bitcoin, whose attributed 2021 annual emissions will produce emissions responsible for around 19,000 future deaths. …”