Proteasomal degradation of the tumour suppressor FBW7 requires branched ubiquitylation by TRIP12 by Omar M. Khan (17807774)

“…We find that SCFFBW7-mediated ubiquitylation of FBW7 occurs preferentially on K404 and K412, but is not sufficient for its proteasomal degradation, and in addition requires TRIP12-mediated branched K11-linked ubiquitylation. TRIP12 inactivation causes FBW7 protein accumulation and increased proteasomal degradation of the SCFFBW7 substrate Myeloid Leukemia 1 (MCL1), and sensitizes cancer cells to anti-tubulin chemotherapy. …”

The effect of self-reported flossing behavior on cardiovascular disease events and mortality Findings from the 2009-2016 National Health and Nutrition Examination Surveys by Nebu, Philip

“…BackgroundThere is increasing evidence suggesting that daily oral hygiene self-care measures may alleviate cardiovascular disease (CVD) risk. …”
Get full text
Get full text
Get full text

An exploration of intelligence management opportunities for organizations in the UAE: Possible challenges for culture by BAHERMEZ, ABDULLA OMAR

“…Effective national culture is positively Linked to business intelligence. Besides, business intelligence enables organizations in the UAE To gain useful insights on consumer behavior. …”
Get full text

Kinetics and adsorption of metolachlor and atrazineand the conversion products (deethylatrazine,deisopropylatrazine, hydroxyatrazine) in the soilprofile of a river basin by Vryzas, Z.

“…We used the batch equilibrium method modified to simulate field conditions as closely as possible for the use and practices related to soil applied pre-emergence herbicides. Pseudo-equilibrium times, determined by kinetic studies, were achieved after 16, 16, 24, 24 and 48 hours for metolachlor, DIA, DEA, HA and atrazine, respectively. …”
Get full text
Get full text
Get full text
Get full text

Immunohistochemical profiling of the heat shock response in obese non-diabetic subjects revealed impaired expression of heat shock proteins in the adipose tissue by Ali Tiss (437068)

“…Impairment of heat shock response (HSR) has been already linked to diabetes and insulin resistance as reflected by decrease in heat shock proteins (HSPs) expression. …”

PSA-activated proaerolysin as a prostate specific cancer therapy by Abi-Habib, Ralph

“…Activity toward proaerolysin was decreased 10-100 fold for each of the proteases tested except PSA, which showed a 4-fold increase in activity against the modified protein. …”
Get full text
Get full text
Get full text

Engineering the Surface and Mechanical Properties of Water Desalination Membranes Using Ultralong Carbon Nanotubes by Yehia M. Manawi (18091207)

“…The water flux of the fabricated membranes increased considerably (up to 20 times) along with the increase in CNT loading. Conversely, yield stress and Young’s modulus of the membranes dropped with the increase in the CNT loading mainly due to porosity increase. …”

DNA methylation signature in peripheral blood reveals distinct characteristics of human X chromosome numerical aberrations by El Maarri, Osman

“…Results DNA methylation changes were widespread on all autosomal chromosomes in 45,X and in 47,XXY individuals, with Turner individuals presenting five times more affected loci. Differentially methylated CpGs, in most cases, have intermediate methylation levels and tend to occur outside CpG islands, especially in individuals with Turner syndrome. …”
Get full text
Get full text
Get full text
Get full text

Development of a multi-zone adiabatic reactor optimization framework for oxidative coupling of methane by Murtaza Ali Khan (22804274)

Skopos in Advertising Translation into Arabic by Haddad, Khalil

Get full text

The Activation Kinetics and Crosstalk of RhoGTPases by Al Haddad, Maria

“…Biosensors are two chromophores linked to 2 entities, joined together by a linker which determines their juxtaposition relative to each other, and thus the amount of energy transfer. …”
Get full text
Get full text
Get full text

Structural and Biophysical Characterization of Stable Alpha-Synuclein Oligomers by Nishant Vaikath (3554687)

“…It has been reported that the brains of deceased patients with PD contain high levels of protein oligomers that are cross-linked to these aldehydes. Increasing evidence also suggests that prefibrillar oligomeric species are more toxic than the mature amyloid fibrils. …”

Genomic and pleiotropic analyses of resting QT interval identifies novel loci and overlap with atrial electrical disorders by Stefan van Duijvenboden (7116386)

“…These findings provide novel insights into how abnormal myocardial repolarization and increased cardiovascular mortality may be linked.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Human Molecular Genetics<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1093/hmg/ddab197" target="_blank">https://dx.doi.org/10.1093/hmg/ddab197</a></p>…”

Assessment of Qatar’s road network under sea-level-rise scenarios using traffic simulation and graph theory by Mohammad Zaher Serdar (17191381)

“…High-resolution maps derived from IPCC-AR6 and NOAA projections show that without adaptation measures, SLR may affect approximately 3–11% of land and 2–17% of roads in Qatar, potentially increasing trip durations up to 15 times. Importantly, the estimated impacts are indicative trends rather than definitive outcomes linked to specific emissions scenarios. …”

Metformin Induces Different Responses in Clear Cell Renal Cell Carcinoma Caki Cell Lines by Mazhar Pasha (11197767)

“…Persistently activated HIF-1α is associated with increased cell proliferation, angiogenesis, and epithelial–mesenchymal transition (EMT), consequently leading to ccRCC progression and metastasis to other organs. …”

Across the Spectrum In-Depth Review AI-Based Models for Phishing Detection by Shakeel Ahmad (702854)

“…<p dir="ltr">Advancement of the Internet has increased security risks associated with data protection and online shopping. …”

Treatment of electrolyte disorders in adult patients in the intensive care unit by Btaiche, Imad F.

Get full text
Get full text
Get full text

Deletion of <i>RFX6</i> impairs iPSC-derived islet organoid development and survival, with no impact on PDX1⁺/NKX6.1⁺ progenitors by Noura Aldous (15429873)

“…Furthermore, RFX6 deficiency resulted in the formation of smaller islet organoids due to increased cellular apoptosis, linked to reduced catalase expression, implying a protective role for RFX6. …”

Governing desalination, managing the brine: A review and systematization of regulatory and socio-technical issues by Mohammad Al-Saidi (5751827)

“…<p>Desalination has become an attractive option for addressing water needs or solving problems of increasing water scarcity and short-term supply interruptions. …”

The Obesity Paradox in Cancer, Tumor Immunology, and Immunotherapy: Potential Therapeutic Implications in Triple Negative Breast Cancer by Adviti Naik (673163)

“…For instance, obesity has emerged as a risk factor for a dampened anti-tumor immune response and increased risk of immunotherapy-induced immune-related adverse events (irAEs) but has also been linked to improved outcomes with checkpoint blockade. …”