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301
Inhibiting HSP90 changes the expression pattern of PINK1 and BNIP3 and induces oxidative stress in colon cancer cells
Published 2025“…Similarly, genetic knockdown of HSP90 in RKO cells produced comparable effects, including reduced cell survival and a decreased PINK1/BNIP3 ratio.</p><h3>Conclusion</h3><p dir="ltr">Targeting HSP90 in colon cancer cells disrupts their survival by decreasing PINK1 and increasing BNIP3, which activates oxidative and endoplasmic reticulum stress, ultimately triggering apoptosis.…”
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302
Hedgehog Signaling Inhibition by Smoothened Antagonist BMS-833923 Reduces Osteoblast Differentiation and Ectopic Bone Formation of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…BMS-833923, a SMO antagonist/Hedgehog inhibitor, exhibited significant inhibitory effects on osteoblast differentiation of hMSCs reflected by decreased ALP activity, in vitro mineralization, and downregulation of osteoblast-related gene expression. …”
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303
Vitamin D association with coagulation factors in polycystic ovary syndrome is dependent upon body mass index
Published 2021“…It is reported that PCOS subjects show marked platelet dysfunction and decreased plasma fibrinolytic activity, resulting in a prothrombotic state. …”
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304
Oxidative stress cytotoxicity induced by platinum-doped magnesia nanoparticles in cancer cells
Published 2021“…Pt/MgO nanoparticles also induced production of reactive oxygen species, decreased cellular glutathione level, and increased lipid peroxidation. …”
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305
Pharmacist Role in Hypertension Management in the Community Setting: Questionnaire Development, Validation, and Application
Published 2023“…Patient satisfaction from the provided interventions/services was determined by means of an overall rating. The correlation between practiced roles and patient satisfaction with received interventions/services was determined.…”
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306
A 5-year trend in the use of sodium-glucose co-transporter 2 inhibitors and other oral antidiabetic drugs in a Middle Eastern country
Published 2022“…Among SGLT2is, empagliflozin prescriptions showed an increase from 537 (10.65%) to 2881 (34.40%) compared to dapagliflozin, which decreased by the end of 2018 from 4505 (89.35%) to 5494 (65.6%).…”
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307
Improving the performance of a commercial absorption cooling system by using ejector: A theoretical study
Published 2023“…It was found that the increase in the ambient temperature not only increased the activation temperature, but it also decreased the COP and increased the circulation ratio (CR). …”
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308
Gut microbiome and Parkinson's disease: Perspective on pathogenesis and treatment
Published 2023“…However, it remains unclear how these mechanisms relate to sporadic PD, a more common form of PD. Both enteric and central nervous systems have been implicated in the pathogenesis of sporadic PD, thus highlighting the crosstalk between the gut and brain. …”
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309
Optimal management, prevalence, and clinical behavior of saddle pulmonary embolism: A systematic review and meta-analysis
Published 2022“…The overall SPE-related mortality rate was 8 % (95 % CI: 5.26–10.96). …”
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310
The effect of Hydrogen Peroxide treatments on dental enamel porosity and protein structure and its long-term implications on tooth hardness and optical properties
Published 2025“…Hardness analysis revealed significant decreases in microhardness in the bleached group compared to the control group (<i>p </i> < 0.05). …”
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311
Global, regional, and national burden of hepatitis B, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019
Published 2022“…HBV-related death rates also decreased, but HBV-related death counts increased as a result of population growth, ageing, and <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/cohort-effect" target="_blank">cohort effects</a>. …”
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312
Non-Isolated DC–DC Power Converter With High Gain and Inverting Capability
Published 2021“…To reduce the ripple in the input current with simultaneous decreasing the input current ripple, a novel current fed interleaved high gain converter is proposed by utilizing the interleaved front-end structure and Cockcroft Walton (CW)-Voltage Multiplier (VM). …”
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313
Self-assembly of Pseudo-Dipolar Nanoparticles at Low Densities and Strong Coupling
Published 2020“…<p dir="ltr">Nanocolloids having directional interactions are highly relevant for designing new self-assembled materials easy to control. …”
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314
Properties and Microstructure Distribution of High-Performance Thermal Insulation Concrete
Published 2020“…This material allows for better thermal insulation properties, thus decreasing the energy usage within the life cycle of the concrete structure. …”
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315
Driving against the clock: Investigating the impacts of time pressure on taxi and non-professional drivers’ safety and compliance
Published 2024“…<p>Drivers often encounter time pressure, which can lead to riskier driving habits, decreased safety margins, and a higher chance of accidents. …”
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316
Characteristics of aerosols and planetary boundary layer dynamics during biomass burning season
Published 2025“…The planetary boundary layer (PBL) height, measured with Ceilometer LIDAR, showed decreasing trend in height from October to December that support aerosol accumulation near the surface during the the month of November. …”
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317
MHD Heat Transfer Enhancement in a Curvilinear Enclosure With Oscillating Wall and Nano‐Encapsulated PCM: A Fluid‐Structure Interaction Analysis
Published 2025“…The electromagnetic field inhibits heat transfer, with Nu decreasing by 25.9% as Ha increases from 0 to 20. These findings provide design guidelines for thermal management applications in electromagnetically active environments.…”
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318
Exploring the LDHC Interactome as Novel Candidate Therapeutic Targets to Advance Breast Cancer Precision Medicine
Published 2024“…<p dir="ltr">Breast cancer remains a major health burden worldwide, being the second most commonly diagnosed cancer, and accounting for the highest cancer-related mortality rate among women. Despite decades of advances in cancer care, the identification of therapeutic targets with higher tumor specificity and favorable safety profiles remains a challenge. …”
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319
Comprehensive Transcriptome and Pathway Analyses Revealed Central Role for Fascin in Promoting Triple-Negative Breast Cancer Progression
Published 2021“…<p dir="ltr">Recent years have witnessed major progress in development of novel therapeutic agents such as chemotherapy, targeted therapy and immune checkpoint inhibitors for breast cancer. However, cancer-related death remains high especially in triple-negative breast cancer (TNBC) due limited therapeutic options. …”
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