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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Urinary Metabolomic Markers of Protein Glycation, Oxidation, and Nitration in Early-Stage Decline in Metabolic, Vascular, and Renal Health
منشور في 2019"…We recruited 200 human subjects with early-stage health decline and healthy controls. Urinary amino acid metabolites were determined by stable isotopic dilution analysis liquid chromatography-tandem mass spectrometry. …"
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The Influence of Loneliness and Living Alone on the Quality of Life of the Elderly: Evidence from Europe
منشور في 2023"…This research indicates a positive correlation between living alone and loneliness, with a greater effect on males, and identifies loneliness as an independent factor decreasing QoL. …"
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4
Rapid mercury removal using living indigenous microalgal communities for water treatment applications
منشور في 2025"…<p dir="ltr">This study investigates the remarkable potential of living Mixed Indigenous Microalgae (<i>MIMA</i>) for mercury bioremediation in aquatic environments at environmentally relevant concentrations (10–100 μg/L). …"
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Influence of temperature on tire-pavement noise in hot climates: Qatar case
منشور في 2021"…There is an apparent trend of decreasing temperature coefficient with increasing mean texture depth of dense graded asphalt pavements. …"
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The Effect of Number of Corrugation on Crashworthiness of Aluminum Corrugated Tube under Lateral Loading
منشور في 2017"…The results show that tubes with corrugations have a higher mean crushing force which is directly proportional to the number of corrugations. …"
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Influence of temperature on tire-pavement noise in hot climates: Qatar case
منشور في 2021"…There is an apparent trend of decreasing temperature coefficient with increasing mean texture depth of dense graded asphalt pavements. …"
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Enhancing Security and Performance in Live VM Migration: A Machine Learning‐Driven Framework With Selective Encryption for Enhanced Security and Performance in Cloud Computing Envi...
منشور في 2025"…<p dir="ltr">Live virtual machine (LVM) migration is pivotal in cloud computing for its ability to seamlessly transfer virtual machines (VMs) between physical hosts, optimise resource utilisation, and enable uninterrupted service. …"
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Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 co...
منشور في 2024"…The progress on reducing the burden of CMNN diseases must not stall; although global trends are improving, the burden of CMNN diseases remains unacceptably high. Evidence-based interventions will help save the lives of young children and mothers and improve the overall health and economic conditions of societies across the world. …"
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Changes in the burden and underlying causes of heart failure in the Eastern Mediterranean Region, 1990–2019: an analysis of the Global Burden of Disease Study 2019
منشور في 2023"…FindingsIn contrast with the decreasing trend of HF burden globally, EMR showed an increasing trend. …"
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A genetically encoded BRET-based SARS-CoV-2 Mpro protease activity sensor
منشور في 2022"…Co-expression of the sensors with M<sup>pro</sup> in live cells resulted in their cleavage while mutation of the critical C145 residue (C145A) in M<sup>pro</sup> completely abrogated their cleavage. …"
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The global, regional, and national burden of inflammatory bowel disease in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 20...
منشور في 2020"…The age-standardised death rate decreased from 0·61 (0·55–0·69) per 100 000 population in 1990 to 0·51 (0·42–0·54) per 100 000 population in 2017. …"
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Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950–2019: a comprehensive demographic anal...
منشور في 2020"…Findings The global TFR decreased from 2·72 (95% uncertainty interval [UI] 2·66–2·79) in 2000 to 2·31 (2·17–2·46) in 2019. …"
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Machine Learning and Carbonate Reservoirs : A Production Data Perspective on Permeability Modelling
منشور في 2024"…It was noted that in cases where permeability increases from one well to another, the production data showed a decrease. Removing these producers from the training dataset led to an 10% decrease in ANN performance, highlighting their importance in capturing the non-linear relationship between permeability and production data.…"
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Children safety risk factors in Khorasan Razavi province
منشور في 2015"…<p dir="ltr">Although there has been a decline in the popularity of walking, it remains a very commonly employed mode of travel and people of almost all ages and sexes walk. …"
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Global, regional, and national age-sex-specific burden of diarrhoeal diseases, their risk factors, and aetiologies, 1990–2021, for 204 countries and territories: a systematic analy...
منشور في 2024"…The most pronounced decline was in children younger than 5 years, with a 79·2% (72·4–84·6) decrease in diarrhoeal deaths. …"
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Investigating the Impact of Salinity Variations on Aerobic Granules and Activated Sludge Flocs: Emphasis on Performance Monitoring and Identification of Influential Salinity Compon...
منشور في 2022"…Cell viability remained unaffected for the reactors operating under single salt solutions of NaCl, while there was a significant reduction in live viabilities following the change to KCl and Na<sub>2</sub>SO<sub>4</sub> solutions to ~ 50%. …"
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Follow up and comparative assessment of IgG, IgA, and neutralizing antibody responses to SARS-CoV-2 between mRNA-vaccinated naïve and unvaccinated naturally infected individuals ov...
منشور في 2023"…At the 7th month, there was a significant decline in antibody responses among VN individuals, but not NI individuals, with a minimum decrease of 3.7-fold (p < 0.001). …"
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Drive‐up INR testing and phone‐based consultations service during COVID‐19 pandemic in a pharmacist‐lead anticoagulation clinic in Qatar: Monitoring, clinical, resource utilization...
منشور في 2023"…Combined with teleclinics, using drive-up fingerstick International normalized ratio (INR) testing was recommended to decrease exposure risk of anticoagulation patients.…"
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Follow up and comparative assessment of IgG, IgA, and neutralizing antibody responses to SARS-CoV-2 between mRNA-vaccinated naïve and unvaccinated naturally infected individuals ov...
منشور في 2023"…At the 7th month, there was a significant decline in antibody responses among VN individuals, but not NI individuals, with a minimum decrease of 3.7-fold (p < 0.001). …"