eIF4A inhibition prevents the onset of cytokine-induced muscle wasting by blocking the STAT3 and iNOS pathways by Zvi Cramer (10742876)

“…Furthermore, we show that hippuristanol perturbs the activation of the STAT3 pathway and expression of STAT3-gene targets such as IL-6. The decreased activation of STAT3, which resulted from a decrease in STAT3 protein expression, was due to the inhibition of STAT3 translation as there were no changes in STAT3 mRNA levels. …”

Loss of FOXA2 induces ER stress and hepatic steatosis and alters developmental gene expression in human iPSC-derived hepatocytes by Maryam Aghadi (17128819)

“…Recently, we generated FOXA2 mutant induced pluripotent stem cell (FOXA2−/−iPSC) lines and illustrated that loss of FOXA2 results in developmental defects in pancreatic islet cells. Here, we used FOXA2−/−iPSC lines to understand the role of FOXA2 on the development and function of human hepatocytes. …”

Design and analysis of PV fed high-voltage gain DC-DC converter using PI and NN controllers by Madisa V.G., Varaprasad

“…The main intention of the modified converter is to decrease the reverse recovery currents and voltage stress across the switch, similarly, it generates high voltage at the converter output. …”
Get full text
Get full text
Get full text

Improving pediatric trauma care: an automated system for wrist trauma detection using GELAN by Promit Basak (22997776)

“…The results of our study highlight the capacity of deep learning to improve the diagnosis of pediatric trauma, decrease the burden on radiologists, and boost patient outcomes.…”

Drive‐up INR testing and phone‐based consultations service during COVID‐19 pandemic in a pharmacist‐lead anticoagulation clinic in Qatar: Monitoring, clinical, resource utilization... by Eman N. Alhmoud (14778706)

“…Combined with teleclinics, using drive-up fingerstick International normalized ratio (INR) testing was recommended to decrease exposure risk of anticoagulation patients.…”

Predictors of prolonged hospitalization among geriatric trauma patients using the modified 5-Item Frailty index in a Middle Eastern trauma center: an 11-year retrospective study by Husham Abdelrahman (768893)

“…There was a significant decrease in the trend of geriatric trauma over the years. …”

Effect of acute and chronic grapefruit, orange and pineaple juice consumption upon blood lipoprotein synthesis and metabolism in the rat. (c2004) by Abou-Khalil, Jamil

Get full text
Get full text

Associations between Bone Mineral Density and WOMAC Scores in Healthy Individuals: Insights from the Qatar Biobank by Mohammed Al-Hamdani (16962702)

“…However, BMD measures significantly contributed to predicting stiffness after controlling for sociodemographic variables (R² = 0.065, ΔF(7, 1724) = 3.34, p= 0.002), with a higher total body BMD associated with increased stiffness and a higher trunk BMD associated with decreased stiffness. …”

An improved non-dimensional model of wet-cooling towers by QURESHI, BILAL AHMED

Get full text

Timing driven genetic placement by Sait, Sadiq M.

Get full text

Carotid artery revascularization through a radiated field by Lesèche, Guy

“…Radiation-induced accelerated atherosclerosis has been recognized for some time.1, 2, 3 and 4 Because of the prolonged survival of patients treated with radiation,5 the frequency of this long-term side effect is expected to increase. In a prospective study, late (>70%) carotid artery stenosis was found in 11.7% of 240 patients who had undergone cervical irradiation.6 The chronic effects of radiation therapy lead to decreased vascularity and increased fibrosis, which in turn lead to risk for tissue necrosis, infection, and ulceration. …”
Get full text
Get full text
Get full text

The effects of long-term testosterone treatment on endocrine parameters in hypogonadal men: 12-year data from a prospective controlled registry study by Aksam Yassin (14779204)

“…In this single-centre, cumulative, prospective, registry study, 321 hypogonadal men (mean age: 58.9 years) received testosterone undecanoate injections in 12-week intervals for up to 12 years. …”

The Photocatalytic Degradation of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin in the Presence of Silver–Titanium Based Catalysts by Samara, Fatin

Get full text

Alterations in blood Lipoprotein & Apolipoprotein B profile induced by moderate acute & chronic alcohol intake in the rat model. (c2002) by Berberi, Rania

“…The studies reported here evaluated the effects of acute and chronic 3% alcohol intake from either beer or whisky in drinking water upon blood lipids, lipoproteins and apolipoprotein B (apo B) profiles in the fasted and postprandial states. …”
Get full text
Get full text

A lipidomic screen of hyperglycemia-treated HRECs links 12/15-Lipoxygenase to microvascular dysfunction during diabetic retinopathy via NADPH oxidase by Ahmed S. Ibrahim (10049522)

“…<p dir="ltr">Retinal hyperpermeability and subsequent macular edema is a cardinal feature of early diabetic retinopathy (DR). Here, we investigated the role of bioactive lipid metabolites, in particular 12/15-lipoxygenase (LOX)-derived metabolites, in this process. …”

Sestrin2 suppression aggravates oxidative stress and apoptosis in endothelial cells subjected to pharmacologically induced endoplasmic reticulum stress by Munazza T. Fatima (17280679)

“…Importantly, SESN2 silencing, unlike thapsigargin, caused a dramatic decrease in protein expression and phosphorylation of Akt, a critical pro-survival hub and component of the AMPK/Akt/mTORC1 axis. …”

Recent advances in the treatment and outcome of locally advanced rectal cancer by Abdalla, Eddie

“…No significant differences were seen in patients (age, gender, race) or tumor characteristics (mean distance from the anal verge, annularity, fixation). …”
Get full text
Get full text

Renal Function Decline in Recipients and Donors of Kidney Grafts by Bahous, Sola Aoun

“…Results: Decline in renal function was estimated at 1-year post-transplantation and annually thereafter (median follow-up 8 years, range 3.6-18.3), as the mean of the annualized decrease in the glomerular filtration rate. …”
Get full text
Get full text
Get full text
Get full text

Empiric antibiotic therapy of community-acquired Pneumonia at the American University of Beirut Medical Center. (c2001) by Cherfan, Antoine

“…Special attention should be given to decrease hospitalization rate, to preserve fluoroquinolones, and to improve microbiological studies outcome.…”
Get full text
Get full text

Adaptation Effectiveness and Free-Riding Incentives in International Environmental Agreements by Benchekroun, Hassan

“…Moreover, we show that this positive effect of an increase in adaptation's effectiveness can also be accompanied by an increase in the gains from global cooperation over GHGs emissions.…”
Get full text
Get full text
Get full text
Get full text