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581
Part II.: Dissimilar friction stir welding of nickel titanium shape memory alloy to stainless steel – microstructure, mechanical and corrosion behavior
منشور في 2021"…<p dir="ltr">In the present work, nickel-titanium (NiTi) shape memory alloys (SMAs) is joined to 304 stainless steel (SS) using friction stir welding (FSW) using process parameters of 400 rpm and a constant tool translation speed of 75 mm/min. …"
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582
Disrupting the α-synuclein-ESCRT interaction with a peptide inhibitor mitigates neurodegeneration in preclinical models of Parkinson’s disease
منشور في 2023"…Furthermore, the peptide inhibitor protects dopaminergic neurons from α-synuclein-mediated degeneration in hermaphroditic C. elegans and preclinical Parkinson’s disease models using female rats. Thus, the α-synuclein-CHMP2B interaction is a potential therapeutic target for neurodegenerative disorders.…"
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583
Tolfenamic Acid Derivatives: A New Class of Transcriptional Modulators with Potential Therapeutic Applications for Alzheimer’s Disease and Related Disorders
منشور في 2023"…Previously, we have shown in AD animal models that tolfenamic acid (TA) can lower the expression of AD-related genes and their products and subsequently reduce pathological burden and improve cognition. Using TA as a scaffold and the zinc finger domain of SP1 as a pharmacophore, we developed safer and more potent brain-penetrating analogs that interfere with sequence-specific DNA binding at transcription start sites and predominantly modulate the expression of SP1 target genes. …"
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584
Sulfobetaine-based polydisulfides with tunable upper critical solution temperature (UCST) in water alcohols mixture, depolymerization kinetics and surface wettability
منشور في 2021"…The regeneration of monomers from the polymers in response to external stimuli was examined using UV–vis and circular dichroism (CD) spectroscopy. …"
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585
Development of new reliability metrics for microgrids: Integrating renewable energy sources and battery energy storage system
منشور في 2023"…These scenarios include the impact of using BESS, changes in RES availability, and variations in RES output. …"
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586
Identification of genetic determinants of breast cancer immune phenotypes by integrative genome-scale analysis
منشور في 2017"…To fill this gap, we mined copy number alteration, somatic mutation, and expression data from The Cancer Genome Atlas (TCGA). By using RNA-sequencing data from 1,004 breast cancers, we defined distinct immune phenotypes characterized by progressive expression of transcripts previously associated with immune-mediated rejection. …"
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587
Examining time-to-transport decisions in Emergency Medical Services
منشور في 2024"…This study examined factors affecting the time elapsed between EMS dispatch and ambulance readiness for the next emergency call using retrospective data from Hamad Medical Corporation Ambulance Service (HMCAS).…"
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588
COVID-19 biomarkers for severity mapped to polycystic ovary syndrome
منشور في 2020"…Statistics were performed using Graphpad Prism 8.0.</p><p dir="ltr">Correction: COVID-19 biomarkers for severity mapped to polycystic ovary syndrome: <a href="https://doi.org/10.1186/s12967-021-02782-w" rel="noreferrer" target="_blank">https://doi.org/10.1186/s12967-021-02782-w</a>, published online 15 March 2021.…"
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589
STIM1 signals through NFAT1 independently of Orai1 and SOCE to regulate breast cancer cell migration
منشور في 2023"…SOCE has been shown to be important for breast cancer cell migration where knockdown of SOCE components (STIM1 or Orai1) decreases cancer metastasis. Here we show unexpectedly that complete knockout of STIM1 (STIM1-KO) using gene editing in metastatic MDA-MB-231 breast cancer cells results in faster migration and enhanced invasion capacity. …"
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590
Past and future climate effects on population structure and diversity of North Pacific surfgrasses
منشور في 2024"…</i></p><h3>Methods</h3><p dir="ltr">We estimated population genetic diversity and structure using 11 polymorphic microsatellite markers. We predicted the distribution of the species for the present, LGM, and near future (RCP 8.5, no climate mitigation) using Species Distribution Models (SDMs).…"
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591
Genome-wide association study and meta-analysis of phytosterols identifies a novel locus for serum levels of campesterol
منشور في 2024"…GWAS was performed on serum levels of β-sitosterol and campesterol using the Metabolon platform from Qatar Biobank (QBB) and genome sequence data provided by Qatar Genome Program. …"
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592
Tailoring the deposition of MoSe<sub>2</sub> on TiO<sub>2</sub> nanorods arrays via radiofrequency magnetron sputtering for enhanced photoelectrochemical water splitting
منشور في 2023"…The fabrication process involves the growth of 1D TiO<sub>2</sub> NRs arrays on FTO substrates using hydrothermal synthesis followed by the deposition of MoSe<sub>2</sub> nanosheets on the TiO<sub>2</sub> NRs using radiofrequency magnetron sputtering (RF magnetron sputtering). …"
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593
Assessing the Electricity Production Capacities of Emerging Markets for the Sustainable Investments
منشور في 2023"…In the following stage, emerging seven economies are ranked by using QSF TOPSIS technique. This situation helps to understand which of these countries are more successful in generating electricity capacity effectively. …"
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594
MHD Heat Transfer Enhancement in a Curvilinear Enclosure With Oscillating Wall and Nano‐Encapsulated PCM: A Fluid‐Structure Interaction Analysis
منشور في 2025"…We investigate thermal transport in a curvilinear enclosure containing NEPCM with an oscillating lower boundary and two cold cylinders under electromagnetic field influence. Using finite element methodology with specialized treatment for moving boundaries, we evaluate key parameters: Rayleigh number (<i>Ra</i>: 10³–10⁵), Stefan number (<i>Ste</i>: 0.1–0.9), phase transition temperature (θf: 0.1–0.9), NEPCM concentration (ϕ: 0.01–0.04), oscillation amplitude (<i>A:</i> 0.01–0.15), Hartmann number (<i>Ha</i>: 0–20), and magnetic field angle (<i>γ</i>: 0°–90°). …"
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595
Factors Associated with Meeting Current Recommendation for Physical Activity in Scottish Adults with Diabetes
منشور في 2019"…Physical activity was evaluated using international guidelines. Overall, 34.1% of the subjects met the recommended levels of physical activity. …"
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596
Driving and hypoglycemia
منشور في 2015"…Hypoglycemia has been associated with cardiac arrhythmia, a decreased ability to drive and driving mishap. Recent meta-analysis of 15 studies showed a risk road traffic collisions (RTC) of 12-19% greater than general populations. …"
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597
Effect of AlN nanoparticle concentration in the electrolyte on corrosion resistance and mechanical properties of the electrodeposited composite coatings
منشور في 2024"…This research aims to develop an innovative solution by incorporating AlN nanoparticles with various concentrations (0.1, 0.2, 0.4, and 0.8 g/L) as reinforcement in the Ni-P electrolyte to develop composite coatings using A36 carbon steel as a substrate through direct current (DC) electrodeposition method. …"
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598
Vertical Distribution of Phosphorous Fractions and Bioavailability of the Nutrient in the Southern Indian Ocean
منشور في 2022"…Sediment samples were collected from two sites in the Indian Ocean during January–February 2010 using gravity corer. Phosphorus fractions in sediments were analyzed by a modified sequential extraction procedure (SEDEX). …"
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599
Sustainable Detoxification of Methylene Blue in Wastewater via Tea Residue Adsorption: Optimization and Kinetics
منشور في 2025"…<p dir="ltr">This study investigates the adsorption efficiency of Methylene Blue (MB) dye using tea waste as a cost-effective and environmentally friendly adsorbent. …"
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600
Applying value-based strategies to accelerate access to novel cancer medications: guidance from the Oncology Health Economics Expert Panel in Qatar (Q-OHEP)
منشور في 2023"…</p><h3>Results</h3><p dir="ltr">Some of the salient recommendations included the development of a formal, fast-track, preliminary approval pathway for drugs needed by patients with severe disease or in critical condition; and encouraging and promoting the conduct of local clinical trials and real-world observational studies using existing registry data. The Q-OHEP also recommended implementing a forecast system using treatment center data based on the supply/demand of formulary oncology drugs to detect treatment patterns, estimate needs, expedite procurement, and prevent shortages/delays. …"