Disrupting the α-synuclein-ESCRT interaction with a peptide inhibitor mitigates neurodegeneration in preclinical models of Parkinson’s disease by Satra Nim (11540447)

“…Furthermore, the peptide inhibitor protects dopaminergic neurons from α-synuclein-mediated degeneration in hermaphroditic C. elegans and preclinical Parkinson’s disease models using female rats. Thus, the α-synuclein-CHMP2B interaction is a potential therapeutic target for neurodegenerative disorders.…”

Tolfenamic Acid Derivatives: A New Class of Transcriptional Modulators with Potential Therapeutic Applications for Alzheimer’s Disease and Related Disorders by Jaunetta Hill (18255631)

“…Previously, we have shown in AD animal models that tolfenamic acid (TA) can lower the expression of AD-related genes and their products and subsequently reduce pathological burden and improve cognition. Using TA as a scaffold and the zinc finger domain of SP1 as a pharmacophore, we developed safer and more potent brain-penetrating analogs that interfere with sequence-specific DNA binding at transcription start sites and predominantly modulate the expression of SP1 target genes. …”

Sulfobetaine-based polydisulfides with tunable upper critical solution temperature (UCST) in water alcohols mixture, depolymerization kinetics and surface wettability by Jozef Kollár (8121347)

“…The regeneration of monomers from the polymers in response to external stimuli was examined using UV–vis and circular dichroism (CD) spectroscopy. …”

Development of new reliability metrics for microgrids: Integrating renewable energy sources and battery energy storage system by Mohammadreza, Gholami

“…These scenarios include the impact of using BESS, changes in RES availability, and variations in RES output. …”
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Identification of genetic determinants of breast cancer immune phenotypes by integrative genome-scale analysis by Wouter Hendrickx (44559)

“…To fill this gap, we mined copy number alteration, somatic mutation, and expression data from The Cancer Genome Atlas (TCGA). By using RNA-sequencing data from 1,004 breast cancers, we defined distinct immune phenotypes characterized by progressive expression of transcripts previously associated with immune-mediated rejection. …”

Examining time-to-transport decisions in Emergency Medical Services by Hassan Farhat (9000509)

“…This study examined factors affecting the time elapsed between EMS dispatch and ambulance readiness for the next emergency call using retrospective data from Hamad Medical Corporation Ambulance Service (HMCAS).…”

COVID-19 biomarkers for severity mapped to polycystic ovary syndrome by Abu Saleh Md Moin (6189512)

“…Statistics were performed using Graphpad Prism 8.0.</p><p dir="ltr">Correction: COVID-19 biomarkers for severity mapped to polycystic ovary syndrome: <a href="https://doi.org/10.1186/s12967-021-02782-w" rel="noreferrer" target="_blank">https://doi.org/10.1186/s12967-021-02782-w</a>, published online 15 March 2021.…”

STIM1 signals through NFAT1 independently of Orai1 and SOCE to regulate breast cancer cell migration by Ayat S. Hammad (9592374)

“…SOCE has been shown to be important for breast cancer cell migration where knockdown of SOCE components (STIM1 or Orai1) decreases cancer metastasis. Here we show unexpectedly that complete knockout of STIM1 (STIM1-KO) using gene editing in metastatic MDA-MB-231 breast cancer cells results in faster migration and enhanced invasion capacity. …”

Past and future climate effects on population structure and diversity of North Pacific surfgrasses by Ana I. Tavares (6942986)

“…</i></p><h3>Methods</h3><p dir="ltr">We estimated population genetic diversity and structure using 11 polymorphic microsatellite markers. We predicted the distribution of the species for the present, LGM, and near future (RCP 8.5, no climate mitigation) using Species Distribution Models (SDMs).…”

Genome-wide association study and meta-analysis of phytosterols identifies a novel locus for serum levels of campesterol by Jamil Mahmoud Alenbawi (21546995)

“…GWAS was performed on serum levels of β-sitosterol and campesterol using the Metabolon platform from Qatar Biobank (QBB) and genome sequence data provided by Qatar Genome Program. …”

Tailoring the deposition of MoSe₂ on TiO₂ nanorods arrays via radiofrequency magnetron sputtering for enhanced photoelectrochemical water splitting by Yahia H. Ahmad (14340210)

“…The fabrication process involves the growth of 1D TiO₂ NRs arrays on FTO substrates using hydrothermal synthesis followed by the deposition of MoSe₂ nanosheets on the TiO₂ NRs using radiofrequency magnetron sputtering (RF magnetron sputtering). …”

Assessing the Electricity Production Capacities of Emerging Markets for the Sustainable Investments by Tamer Aksoy (17947802)

“…In the following stage, emerging seven economies are ranked by using QSF TOPSIS technique. This situation helps to understand which of these countries are more successful in generating electricity capacity effectively. …”

MHD Heat Transfer Enhancement in a Curvilinear Enclosure With Oscillating Wall and Nano‐Encapsulated PCM: A Fluid‐Structure Interaction Analysis by Mohammed Azeez Alomari (20482592)

“…We investigate thermal transport in a curvilinear enclosure containing NEPCM with an oscillating lower boundary and two cold cylinders under electromagnetic field influence. Using finite element methodology with specialized treatment for moving boundaries, we evaluate key parameters: Rayleigh number (<i>Ra</i>: 10³–10⁵), Stefan number (<i>Ste</i>: 0.1–0.9), phase transition temperature (θf: 0.1–0.9), NEPCM concentration (ϕ: 0.01–0.04), oscillation amplitude (<i>A:</i> 0.01–0.15), Hartmann number (<i>Ha</i>: 0–20), and magnetic field angle (<i>γ</i>: 0°–90°). …”

Factors Associated with Meeting Current Recommendation for Physical Activity in Scottish Adults with Diabetes by Ahmad Salman (3173418)

“…Physical activity was evaluated using international guidelines. Overall, 34.1% of the subjects met the recommended levels of physical activity. …”

Driving and hypoglycemia by Stephen Beer (5480411)

“…Hypoglycemia has been associated with cardiac arrhythmia, a decreased ability to drive and driving mishap. Recent meta-analysis of 15 studies showed a risk road traffic collisions (RTC) of 12-19% greater than general populations. …”

Effect of AlN nanoparticle concentration in the electrolyte on corrosion resistance and mechanical properties of the electrodeposited composite coatings by M.S. Khan (22047413)

“…This research aims to develop an innovative solution by incorporating AlN nanoparticles with various concentrations (0.1, 0.2, 0.4, and 0.8 g/L) as reinforcement in the Ni-P electrolyte to develop composite coatings using A36 carbon steel as a substrate through direct current (DC) electrodeposition method. …”

Vertical Distribution of Phosphorous Fractions and Bioavailability of the Nutrient in the Southern Indian Ocean by Muhammed Nayeem Mullungal (21385463)

“…Sediment samples were collected from two sites in the Indian Ocean during January–February 2010 using gravity corer. Phosphorus fractions in sediments were analyzed by a modified sequential extraction procedure (SEDEX). …”

Sustainable Detoxification of Methylene Blue in Wastewater via Tea Residue Adsorption: Optimization and Kinetics by Farah F. Salameh (21797300)

“…<p dir="ltr">This study investigates the adsorption efficiency of Methylene Blue (MB) dye using tea waste as a cost-effective and environmentally friendly adsorbent. …”

Applying value-based strategies to accelerate access to novel cancer medications: guidance from the Oncology Health Economics Expert Panel in Qatar (Q-OHEP) by Anas Hamad (9545771)

“…</p><h3>Results</h3><p dir="ltr">Some of the salient recommendations included the development of a formal, fast-track, preliminary approval pathway for drugs needed by patients with severe disease or in critical condition; and encouraging and promoting the conduct of local clinical trials and real-world observational studies using existing registry data. The Q-OHEP also recommended implementing a forecast system using treatment center data based on the supply/demand of formulary oncology drugs to detect treatment patterns, estimate needs, expedite procurement, and prevent shortages/delays. …”

Enhanced optical properties of <i>β</i>-Ga₂O₃-_<em>x</em>S_<em>x</em>S: A DFT study by G.B. Eshonqulov (22927297)

“…The present predictive modeling can be useful for developing Ga₂O₃-based materials for optoelectronic applications.…”