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Modulation of SLFN11 induces changes in DNA Damage response in breast cancer
Published 2023“…Finally, as a definitive and specific way to modulate SLFN11 expression we implemented SLFN11 dCas9 (dead CRISPR associated protein 9) systems to specifically increase or decrease SLFN11 expression.</p><h3>Results</h3><p dir="ltr">After confirming the previously reported correlation between methylation of SLFN11 promoter and its expression across multiple cell lines, we showed in-vitro that decitabine and IFN-γ could increase moderately the expression of SLFN11 in both BT-549 and T47D cell lines. …”
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Thymoquinone from Nigella sativa seeds promotes the antitumor activity of noncytotoxic doses of topotecan in human colorectal cancer cells in vitro
Published 2016“…Cell cycle arrest in the S phase was detected with each compound separately, while combined treatment only increased the production of fragmented DNA. Both compounds induced apoptosis through the extrinsic pathway after 24 hours; however, after 48 hours, the intrinsic pathway was activated by topotecan treatment only. …”
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223
Nonlinearities in the response of real GDP to oil price shocks
Published 2017“…Finally, evidence of asymmetry vanishes after computing specification robust critical values.…”
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224
Exploring the effect of change order on the project team bahavior and performance
Published 2016“…Since the change order is part of the construction project, the relationship between change order (variation order) and project team behavior and performance were analyzed and studied before, during and after an event in this research. In addition, In order to understand the concept of change order, this research was identified the factors that generate the change order on the construction project. …”
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225
Environmental enrichment and cafeteria diet synergistically modify the response to chronic variable stress in rats
Published 2013“…Stressed animals showed increased serum corticosterone (CORT) levels compared to non-stressed animals (P<0.001). …”
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226
Optimal Planning of Distributed Generators and Shunt Capacitors in Isolated Microgrids With Nonlinear Loads
Published 2020“…Given the necessity of supply continuity for isolated microgrids after a contingency, the proposed planning approach takes into consideration the reliability to increase the probability of building successful islands. …”
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227
Using primary healthcare facilities and patients’ expectations about triage system: Patients’ perspective from multisite Jordanian hospitals
Published 2024“…<h3>Background</h3><p dir="ltr"> Using primary healthcare facilities can decrease the tension and workload in emergency departments (EDs). …”
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228
The effects of Cucurbita pepo seeds on testosterone induced benign prostatic hyperplasia
Published 2011“…Results showed that pumpkin seeds exerted maximum inhibition (86.7, 98.0 and 98.4%) of hyperplasia at 30% w/w dose after 12, 24 and 36 days respectively. They were comparable to finasteride (78.1, 89.5 and 96.4%). …”
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Empirical evaluation of change in crash risk due to lane marking reallocation: A case study in Kochi City, Japan
Published 2023“…In addition, the results indicate that the PICUD value tends to decrease (i.e., the crash risk tends to increase) with increasing speed of the following vehicle relative to the leading vehicle. …”
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231
Assessment of tropospheric NO<sub>2</sub> concentrations over greater Doha using Sentinel-5 TROPOspheric monitoring instrument (TROPOMI) satellite data: Temporal analysis, 2018–202...
Published 2024“…<p dir="ltr">This study presents a temporal evaluation of the tropospheric NO<sub>2</sub> column densities over Greater Doha using TROPOMI satellite data from May 2018 to December 2023, and an assessment of the impact of the preparations and hosting of the FIFA Football World Cup Qatar 2022, on NO<sub>2</sub> levels before, during and after the tournament over Greater Doha. Analysis of annual NO<sub>2</sub> levels from 2019 to 2023 showed an increase in 2022 compared to that of the previous three years and a clear decrease in 2023 post the completion of the world cup preparations and hosting. …”
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232
Adopting Geophysical Testing Techniques in Geotechnical Investigation and Shallow Foundation Design
Published 2018Get full text
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233
An Analysis of Thermal Comfort at the School Outdoor Spaces: A Case Study of the American School of Creative Science, Dubai, UAE
Published 2022“…The enhanced outcome was evaluated against the initial one, using PET (physiological equivalent temperature), revealing that shade separately had the highest impact on its corresponding location with a decrease of up to 16% in PET, but no decrease to the overall PET of the microclimate. …”
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234
Efficacy of Antimicrobial-Impregnated Catheters in Preventing Sepsis Post Peripherally Inserted Central Venous Catheter (PICC) Removal in Neonates: A Retrospective Study
Published 2023“…<h3>Background</h3> <p>Peripherally inserted central venous catheters (PICCs) are commonly used to deliver total parenteral nutrition and medication to newborn infants in the neonatal intensive care unit (NICU). Sepsis after PICC removal has been reported in several studies and can increase the incidence of late-onset sepsis and length of stay. …”
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ON-LINE MEASUREMENTS OF OXIDATION OF CARBON USING VISIBLE SPECTROSCOPY
Published 2020“…An interesting observation is an exponential increase in the evolution of CO typically after about 10 minutes from the initiation of the discharge. …”
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236
The July war and its effects on Lebanon’s power-sharing
Published 2007“…This paper examines Lebanon’s fragile politics of accommodation in the wake of the Hezbollah-Israeli war in July 2006. After drawing attention to the dangerous emergence of a bipolar and unstable power-sharing model between Lebanese dissenting factions, it shows how a flimsy elite consensus, divergent perceptions of external threat, the republic’s entanglement in the regional and international orbits as well as the increase of foreign pressures since the 2005 Beirut Spring could impede the pacification of a divided society. …”
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237
The effects of a change in the point system on immigration
Published 2016“…The explicit objective was to increase the number of French-speaking immigrants, with no deterioration in overall labor market performance. …”
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Clustering records in information retrieval systems. (c1995)
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239
Corporate governance and quality of accounting information
Published 2012“…After studying several global models of governance taking into consideration the laws of corporate governance in some Asia countries, the authors concluded that the same criteria cannot be applied to all countries present in Asia. …”
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The effects of Ramadan fasting on clinical and biochemical markers among hemodialysis patients: A prospective cohort study
Published 2019“…RPFG also had slight increase in mean IDWG than RNFG by 0.35 kg (95% CI 0.11, 0.60). …”