A modified lipid composition in Fabry disease leads to an intracellular block of the detergent-resistant membrane-associated dipeptidyl peptidase IV by Rizk, Sandra

“…The consequences of these alterations on the targeting of membrane proteins are poorly understood. …”
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ACTB Loss-of-Function Mutations Result in a Pleiotropic Developmental Disorder by Sara Cuvertino (18892069)

“…We also demonstrate that <i>ACTB</i> haploinsufficiency leads to reduced cell proliferation, altered expression of cell-cycle genes, and decreased amounts of nuclear, but not cytoplasmic, β-actin. …”

Heat Transfer From a 2D Backward Facing Step With Isotropic Porous Floor Segments by A/K Abu-Hijleh, Bassam

“…Depending on the configuration, axial variation of the local Nusselt number could be altered. For all configurations, the overall Nusselt number decreased by as much as 16% while the maximum local Nusselt number increased by as much as 170%, both relative to their respective values for the reference case of a solid floor.…”
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Synergistic Effect of Epigenetic Inhibitors Decitabine and Suberoylanilide Hydroxamic Acid on Colorectal Cancer In vitro by Najem, Sonia A.

“…Background: Colorectal Cancer (CRC) is a common cause of oncological deaths worldwide. Alterations of the epigenetic landscape constitute a well-documented hallmark of CRC phenotype. …”
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Evaluation of cationic channel TRPV2 as a novel biomarker and therapeutic target in Leukemia-Implications concerning the resolution of pulmonary inflammation by Kodappully S. Siveen (4246150)

“…Challenging lung airway epithelial cells (AECs) with LBCs decreased (by more than 50%) transepithelial resistance (TER) denoting barrier function alteration. …”

Custom foot orthoses improve performance, but do not modify the biomechanical manifestation of fatigue, during repeated treadmill sprints by Olivier Girard (409080)

“…Regardless of footwear condition, mean horizontal forces, step frequency, vertical and leg stiffness decreased from sprint 1 to sprint 8 (all <i>P</i> < 0.001). …”

Can bitcoin’s volatility be tamed? by Ammous, Saifedean

“…No potential alterations to Bitcoin’s design can thus be expected to alleviate its volatility. …”
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Investigation of the Effect of Exendin-4 on Oleic Acid-Induced Steatosis in HepG2 Cells Using Fourier Transform Infrared Spectroscopy by Olfa Khalifa (10914452)

“…We investigated the biochemical alterations induced by steatosis and Ex-4 treatment using Fourier transform infrared (FTIR) spectroscopy and chemometric analyses. …”

Zirconium Silicate/IL/Mxene-based composite membranes for high-temperature fuel cell applications by Edwin, Reeves Nayagam

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Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2... by Michael, Brauer

“…Estimates reported represent the mean value across 500 draws from the estimate's distribution, with 95% uncertainty intervals (UIs) calculated as the 2·5th and 97·5th percentile values across the draws. …”
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Effects of the addition of a high energy density fuel, adamantane to diesel on its cetane number, sooting propensity, and soot nanostructural properties by Al Zaabi, Alanood

“…Another method to reduce soot could be to increase its reactivity by altering its physicochemical properties (e.g., introducing curvatures in its nanostructures) so that it oxidizes inside the engine or flame. …”
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Combinatory effect of diet and exercise on brain derived neurotrophic factor expression, cognitive function and behavioral phenotypes of psychiatric disorders. (c2017) by Abou Haidar, Edwina T.

“…BDNF levels are dramatically decreased in the adult brain in response to stress and are elevated by increased exercise. …”
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Heat Shock-Related Protein Responses and Inflammatory Protein Changes Are Associated with Mild Prolonged Hypoglycemia by Abu Saleh Md Moin (6189512)

“…At hypoglycemia, UBE2N, STIP1, and UBE2L3 increased (all p < 0.05), whilst TLR4:MD-2 and HSPA8 decreased (p < 0.05) in T2D versus baseline. In follow-up after hypoglycemia, HSPs normalized to baseline by 24 h, except UBE2L3 (p < 0.05), which was decreased in controls versus baseline. …”

Effects of COVID-19 on Autism Spectrum Disorder in Qatar by Fouad A. Alshaban (17281108)

“…Parents also reported decreased access to family and social support networks, as well as decreased quality of clinical and community support. …”

Connexin 43 Loss Triggers Cell Cycle Entry and Invasion in Non-Neoplastic Breast Epithelium: A Role for Noncanonical Wnt Signaling by Fostok, Sabreen

“…Background: The expression of connexin 43 (Cx43) is disrupted in breast cancer, and re-expression of this protein in human breast cancer cell lines leads to decreased proliferation and invasiveness, suggesting a tumor suppressive role. …”
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Aorta deformation linked to heart disease by Nature Research (16552612)

“…They found that the mechanics of the aorta were altered, with the pulsatile change in aortic diameter, distention and elasticity of the aortic walls being significantly decreased, and aortic stiffness significantly increased, in HCM patients compared to the controls. …”

PSA-activated proaerolysin as a prostate specific cancer therapy by Abi-Habib, Ralph

“…Modification of native proaerolysin to PRX302 markedly altered the activity of each of the proteases (chymotrypsin, trypsin, furin, and thrombin) tested toward this protein. …”
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Removal of copper ions from aqueous solution using NaOH-treated rice husk by Shagufta Zafar (10027380)

“…The %RCu decreased by increasing the [Cu]i and increased by increasing the ct, Dad, and T. …”

Role of Edge Groups in Defining the Stability of Aromatic Molecules Under Electron Irradiation by Y. Tong (18394389)

“…Our findings show the importance of the oligomeric units in altering the properties of thiol-terminated molecular self-assemblies by electron irradiation.…”

IS security menace by Balozian, Puzant

“…Nevertheless, this manuscript challenges that notion and advances a stream of research that suggests increasing security measures may lead to decrease in user productivity, increased user mistrust in the IT department, increased user frustration, increased user technology avoidance, increased non-malicious volitional security violations and overall may lead to increased security risk, instead of decreasing it. …”
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