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ROS, K<sup>+</sup> efflux and cathepsin B are required for NLRP3 activation.
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related to Fig 4. ROS, K+ efflux and cathepsin B do not affect TNFα production in response to eggs.
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Eggs jointly coordinate a caspase-1 and caspase-8 dependent pyroptotic cell death.
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The loss of NLRP3 and AIM2 results in reduced Th17 and enhanced Th2 cytokine responses.
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Gsdmd deficiency reduces myeloid cell recruitment to the liver during schistosome infection.
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Egg-induced IL-1β and IL-17 production is dependent on both Caspase-1 and Caspase-8.
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