Rad53 orchestrates divergent pathways governing genotoxic resistance, morphogenesis, and virulence in <i>Candida albicans</i>: Mechanistic decoupling through overexpression analysi... od Jia Wang (51945)

“…Investigating cellular modifications resulting from increased Rad53 functionality is essential for a deeper understanding of its regulatory response. …”

A Robust Hybrid Skeleton for Omnidirectional Underwater Bubble Collection od Lei Dong (165252)

“…This study provides a practical solution for underwater bubble collection, overcoming the constraints of surface-only modifications and the material limitations of polymers and metals prevalent in current research.…”

Identification of a novel enhancer regulating CYP4B1 expression. od Li Dai (159381)

“…<p><b>(A)</b> Overview of the H3K4me1 and H3K27ac modifications near the 3′ UTR region of <i>CYP4B1</i> in the heart and lung tissues, as well as in A549 and PC9 LC cells. …”

A Robust Hybrid Skeleton for Omnidirectional Underwater Bubble Collection od Lei Dong (165252)

“…This study provides a practical solution for underwater bubble collection, overcoming the constraints of surface-only modifications and the material limitations of polymers and metals prevalent in current research.…”

Enhanced Adsorption and Enzymatic Hydrolysis of Polyethylene Terephthalate by Cutinase with an N‑Terminal Hydrophobic Tether od Md Sadikur Rahman Shuvo (22374895)

“…The enzyme kinetic parameters of both conjugated and unconjugated cutinases revealed that the modifications have a minimal impact on catalytic activity. …”

Enhanced Adsorption and Enzymatic Hydrolysis of Polyethylene Terephthalate by Cutinase with an N‑Terminal Hydrophobic Tether od Md Sadikur Rahman Shuvo (22374895)

“…The enzyme kinetic parameters of both conjugated and unconjugated cutinases revealed that the modifications have a minimal impact on catalytic activity. …”

Meta-analysis of the safety and efficacy of fresh frozen plasma exchange in the treatment of organophosphate pesticide poisoning od Binrong Cai (22145570)

“…According to the latest standards for publishing articles by the superior hospital, for the five authors Binrong Cai, Xian Yu, Xiaoyan Xian, Lipeng Liu, and Bin He who are employed at West China Tianfu Hospital, Sichuan University, a second affiliation needs to be added. The modifications and annotations have been made in the manuscript (in the section of authors and affiliation).…”

Table 1_High-throughput end-to-end aphid honeydew excretion behavior recognition method based on rapid adaptive motion-feature fusion.docx od Zhongqiang Song (21669041)

“…Simultaneously, the RT-DETR detection model underwent deep optimization: a spline-based adaptive nonlinear activation function was introduced, and the Kolmogorov-Arnold network was integrated into the deep feature stage of the ResNet50 backbone network to form the RK50 module. These modifications enhanced the model’s capability to capture complex spatial relationships and subtle features.…”

Data Sheet 1_Single-stranded DNA (ssDNA) donor repair templates and CRISPR/Cas9 enable a high-frequency of targeted insertions in potato.xlsx od Matías N. González (22274314)

“…We further assessed strategies to favour HDR over alternative repair outcomes, including the use of small molecules known to inhibit competing pathways in animal systems, and modifications to DRTs to enhance their availability in the vicinity of the target site. …”

Expert consensus definition of treatment intolerance in chronic myeloid leukemia in chronic phase od Ehab Atallah (17664292)

“…The group defined TKI treatment intolerance as patients whose AEs often interfered with daily activities, leading to TKI modifications. Panelists developed a tool to assess patient intolerance and recommendations for managing TKI therapy in the context of intolerance.…”

Concentration-Specific Neurotoxic Pathways of Tetrabromobisphenol A and Tetrabromobisphenol A Bis(2-Hydroxyethyl Ether) in Zebrafish Larvae od Hai Xu (141126)

“…In contrast, exposure to environmentally relevant concentrations induced similar phenotypes (craniofacial malformations and apoptosis) without major changes in neurotransmitter levels, suggesting that low-dose neurotoxicity might be mediated by alternative, less understood mechanisms, possibly involving epigenetic modifications or compensatory neuronal adaptations. These findings underscore the complexity of low-dose toxicity and the need for further research into the molecular pathways underlying the neurotoxic effects of TBBPA and its derivatives, particularly at environmentally relevant concentrations.…”

Enhanced Adsorption and Enzymatic Hydrolysis of Polyethylene Terephthalate by Cutinase with an N‑Terminal Hydrophobic Tether od Md Sadikur Rahman Shuvo (22374895)

“…The enzyme kinetic parameters of both conjugated and unconjugated cutinases revealed that the modifications have a minimal impact on catalytic activity. …”

Table 1_Effects of gut microbiota interventions on patients with schizophrenia: a systematic review and meta-analysis.docx od Nianhua Ye (22570238)

“…., probiotics, prebiotics, synbiotics, dietary modifications and fecal microbiota transplantation) have been widely applied in the treatment of SCH, the most effective intervention strategy remains uncertain.…”

Table 4_Association between the serum albumin-to-creatinine ratio and 28-day all-cause mortality in sepsis: a retrospective cohort study.docx od Kerui Wu (10329647)

“…Explored the relationship between ACR and 28-day all-cause mortality using Cox proportional risk regression and Kaplan–Meier survival curves, and conducted subgroup analysis to evaluate the effect modifications across different patient populations. Applied the restricted cubic spline (RCS) curves to assess the nonlinear relationships, and the receiver operating characteristic (ROC) curve to assess the predictive performance.…”

Table 1_Association between the serum albumin-to-creatinine ratio and 28-day all-cause mortality in sepsis: a retrospective cohort study.docx od Kerui Wu (10329647)

“…Explored the relationship between ACR and 28-day all-cause mortality using Cox proportional risk regression and Kaplan–Meier survival curves, and conducted subgroup analysis to evaluate the effect modifications across different patient populations. Applied the restricted cubic spline (RCS) curves to assess the nonlinear relationships, and the receiver operating characteristic (ROC) curve to assess the predictive performance.…”

Table 5_Association between the serum albumin-to-creatinine ratio and 28-day all-cause mortality in sepsis: a retrospective cohort study.docx od Kerui Wu (10329647)

“…Explored the relationship between ACR and 28-day all-cause mortality using Cox proportional risk regression and Kaplan–Meier survival curves, and conducted subgroup analysis to evaluate the effect modifications across different patient populations. Applied the restricted cubic spline (RCS) curves to assess the nonlinear relationships, and the receiver operating characteristic (ROC) curve to assess the predictive performance.…”

Data Sheet 2_Antibiotic-induced gut microbiota depletion enhances glucose tolerance linked to GLP-1 signaling.docx od Alexandra Kellenberger (13833485)

“…In this study, we aimed to determine whether the browning effect observed after antibiotic treatment contributes to metabolic modifications and to investigate the potential central role of GLP-1 in enhancing glucose metabolism.…”

Concentration-Specific Neurotoxic Pathways of Tetrabromobisphenol A and Tetrabromobisphenol A Bis(2-Hydroxyethyl Ether) in Zebrafish Larvae od Hai Xu (141126)

“…In contrast, exposure to environmentally relevant concentrations induced similar phenotypes (craniofacial malformations and apoptosis) without major changes in neurotransmitter levels, suggesting that low-dose neurotoxicity might be mediated by alternative, less understood mechanisms, possibly involving epigenetic modifications or compensatory neuronal adaptations. These findings underscore the complexity of low-dose toxicity and the need for further research into the molecular pathways underlying the neurotoxic effects of TBBPA and its derivatives, particularly at environmentally relevant concentrations.…”

Well-Tempered Metadynamic Simulations Provide Insights and Leads for Designing Effective Allosteric Inhibitors against SARS-CoV‑2 RNA-Dependent RNA Polymerase od Wilbee D. Sasikala (1751080)

“…The preliminary functional group modifications of lead molecules identified through WT-MD showed improved binding energy toward SARS-CoV-2 RdRp. …”

Enhanced Adsorption and Enzymatic Hydrolysis of Polyethylene Terephthalate by Cutinase with an N‑Terminal Hydrophobic Tether od Md Sadikur Rahman Shuvo (22374895)

“…The enzyme kinetic parameters of both conjugated and unconjugated cutinases revealed that the modifications have a minimal impact on catalytic activity. …”