Unconventional nucleus export and secondary necrosis of human leukemia T lymphocytes (Jurkat cells) transfected with <i>HIV-1 LTR CAT-TAT-72</i>: ultrastructural assessment von Jacques Gilloteaux (19337436)

“… The lack of fine structure in Jurkat cells and both transfected cells aimed at us to verify their respective ultrastructure modifications. Scanning and transmission electron microscopy showed evident Cajal bodies in CTJ cells compared with WT cells and revealed unconventional nucleus export of viral-associated transcripts where eruption of the nucleus envelope spilled content from the perinuclear space toward exocytosis via a lined membranous channel continuum of endoplasmic reticulum – mitochondria envelope.  …”

Image 1_Construction of a glycosylation-related prognostic signature for predicting prognosis, tumor microenvironment, and immune response in soft tissue sarcoma.jpeg von Ningning Yuan (4231858)

“… Background<p>Altered glycosylation, one of the most common post-translational protein modifications, plays a critical role in the initiation and progression of soft tissue sarcoma (STS).  …”

Example data from the Invasion Assay with various single- and double-stranded ON probes. von Michaela E. Everly (22530414)

“… Note, the 3’-biotin TEG and 5’-amino-modifier modifications present in some Invader probes are not necessary for the protocol. …”

Enhanced Third-Order Nonlinear Optical Response in Cross-Conjugated Pyrrole-Based <i>ortho</i>-Halo Arylhydrazono-β-Diketones von Deyona M Jose (22652332)

“… Combined experimental and theoretical analyses revealed that both halogen and pyrrole modifications significantly altered the electronic polarization and third-order NLO responses.  …”

Image 5_Pan-cancer analysis reveals ELFN1 as a novel prognostic biomarker and immunotherapeutic target associated with tumor microenvironment remodeling and promoting malignant phe... von Sha-Sha Hu (6417878)

“… </p>Methods<p>Through integrative analysis of TCGA and GTEx datasets, we systematically characterized ELFN1 across 33 cancer types, including its expression patterns, prognostic value, mutation landscape, methylation modifications, protein-protein interaction (PPI) networks, and the relationship between ELFN1 expression and immune infiltration.  …”

Image 10_Pan-cancer analysis reveals ELFN1 as a novel prognostic biomarker and immunotherapeutic target associated with tumor microenvironment remodeling and promoting malignant ph... von Sha-Sha Hu (6417878)

“… </p>Methods<p>Through integrative analysis of TCGA and GTEx datasets, we systematically characterized ELFN1 across 33 cancer types, including its expression patterns, prognostic value, mutation landscape, methylation modifications, protein-protein interaction (PPI) networks, and the relationship between ELFN1 expression and immune infiltration.  …”

SceneEdited - Patch Data Base von Chun-Jung Lin (16626240)

“… <b>SceneEdited</b> contains over 800 up-to-date scenes covering 73 km of driving and approximate 3 km² of urban area, with more than 23,000 synthesized object changes created both manually and automatically across 2000+ out-of-date versions, simulating realistic urban modifications such as missing roadside infrastructure, buildings, overpasses, and utility poles.  …”

Table 1_Genome-wide DNA methylation analysis identifies kidney epigenetic dysregulation in a cystinosis mouse model.xlsx von M. N. Rossi (22100030)

“… Recent studies suggest that epigenetic modifications, particularly DNA methylation (DNAm), play a critical role in the development of chronic kidney disease.  …”

Image 1_Deciphering the epigenetic role of KDM4A in pancreatic β-like cell differentiation from iPSCs.tiff von Felipe Arroyave (22533818)

“… Epigenetic barriers, such as histone modifications, may hinder proper differentiation and the acquisition of essential maturation markers in these cells. …”

Image 6_Pan-cancer analysis reveals ELFN1 as a novel prognostic biomarker and immunotherapeutic target associated with tumor microenvironment remodeling and promoting malignant phe... von Sha-Sha Hu (6417878)

“… </p>Methods<p>Through integrative analysis of TCGA and GTEx datasets, we systematically characterized ELFN1 across 33 cancer types, including its expression patterns, prognostic value, mutation landscape, methylation modifications, protein-protein interaction (PPI) networks, and the relationship between ELFN1 expression and immune infiltration.  …”

Table 3_Pan-cancer analysis reveals ELFN1 as a novel prognostic biomarker and immunotherapeutic target associated with tumor microenvironment remodeling and promoting malignant phe... von Sha-Sha Hu (6417878)

“… </p>Methods<p>Through integrative analysis of TCGA and GTEx datasets, we systematically characterized ELFN1 across 33 cancer types, including its expression patterns, prognostic value, mutation landscape, methylation modifications, protein-protein interaction (PPI) networks, and the relationship between ELFN1 expression and immune infiltration.  …”

Table 2_Age-dependent association between lifestyle oxidative balance score and bone mineral density in children and adolescents: evidence from the NHANES 2015–2018.docx von Suman Li (21659210)

“… Interaction and subgroup analyses were used to examine age-related modifications. The mediation effect of oxidative stress-related indicators in the relationship between OBS and BMD was analyzed using mediation analysis. …”

Supplementary file 1_Community health worker roles in intervention delivery: a scoping review of heart disease and stroke prevention trials in the United States.docx von Imama A. Naqvi (14258834)

“… CHWs were actively engaged in implementing interventions, providing culturally sensitive education, offering health coaching, and supporting lifestyle modifications, such as increased physical activity and medication compliance.  …”

Data Sheet 1_Histone-related gene WDR77 promotes tumor progression through cell cycle regulation in skin cutaneous melanoma.zip von Haoxue Zhang (12208580)

“… Epigenetic dysregulation, particularly histone modifications, contributes to disease progression. However, effective histone-based prognostic biomarkers are still lacking in clinical practice. …”

G. Mitsiou_SPIRIT_checklist.pdf “The effect of inspiratory muscle training on dysfunctional breathing and functional ability in patients with chronic heart failure. A study protoco... von Georgios Mitsiou (22280518)

“… The study fully adheres to the Helsinki Declaration's "Ethical Principles of Medical Research Involving Human Subjects." Any protocol modifications will be promptly disclosed to the Ethics Committee.  …”

SceneEdited - Scene Data Base von Chun-Jung Lin (16626240)

“… <b>SceneEdited</b> contains over 800 up-to-date scenes covering 73 km of driving and approximate 3 km² of urban area, with more than 23,000 synthesized object changes created both manually and automatically across 2000+ out-of-date versions, simulating realistic urban modifications such as missing roadside infrastructure, buildings, overpasses, and utility poles.  …”

Biomethanation of alkaline waste sludge in haloalkaline conditions: combined proof of concept experiments and technical economic evaluation von Ramon Zwaan (22673727)

“… </p> <p>First successful semi-continuous biomethane production under alkaline conditions from complex substrate</p> <p>Techno economic evaluation: Scaling-up and scaling-down analyses identified bottlenecks that are relatively easy to resolve</p> <p>Next research steps and operational modifications to overcome bottlenecks were identified</p> <p>Alkaline fermentation is an attractive in-situ method for biomethane production with eventual CO₂ sequestration and nutrient recovery, instead of ex-situ biogas upgrading technologies. …”

Data Sheet 1_Human–climate–environment interactions in Espiritu Santo, Vanuatu during the past millennium.docx von Giorgia Camperio (5742611)

“… This study contributes to our understanding of the intricate relationship between human activities, climatic fluctuations, and landscape modifications in Remote Oceania over the past millennium. …”

Table 4_Pan-cancer analysis reveals ELFN1 as a novel prognostic biomarker and immunotherapeutic target associated with tumor microenvironment remodeling and promoting malignant phe... von Sha-Sha Hu (6417878)

“… </p>Methods<p>Through integrative analysis of TCGA and GTEx datasets, we systematically characterized ELFN1 across 33 cancer types, including its expression patterns, prognostic value, mutation landscape, methylation modifications, protein-protein interaction (PPI) networks, and the relationship between ELFN1 expression and immune infiltration.  …”

Data Sheet 1_Surface analysis of Metrohm BT220 screen-printed electrodes through electrochemical techniques: importance of pretreatment.zip von Chun Keat Khor (22262011)

“… This analysis provides insight into how to optimize the SPE’s pre-treatment, ensuring the sensor platform is consistent and the surface is reproducible before biological modifications, which in turn yields more steadfast results for biosensor development. …”