Image 1_Behavioral benefits of GSK-3β inhibition and state-dependent microtubule signatures in the Fmr1-KO mouse.jpeg de réir John Kealy (17399515)

“…We examined behaviors and hippocampal α-tubulin post-translational modifications (PTMs) in Fmr1-KO male mice without and with chronic administration of the GSK-3β inhibitors SB216763 (30 mg/kg, i.p.) and AF3581 (10 mg/kg, i.p.). …”

Table 1_Epigenetic landscape reveals MEF2 and SIX family-mediated transcriptional networks underlying dietary NFC/NDF ratio-induced muscle development and meat quality in Tibetan s... de réir Rengeerli Sa (20641985)

“…RNA-seq confirmed functional associations between epigenetic modifications and gene expression, revealing enrichment of fatty acid metabolism, epithelial cell proliferation, and macrophage chemotaxis pathways. …”

Table 1_Epigenetic dysregulation-induced metabolic reprogramming fuels tumor progression in bladder cancer.xlsx de réir Jian Zhang (1682)

“…Upstream analysis identified epigenetic modifications, particularly DNA hypermethylation of tumor suppressor metabolic hubs and reduced USF2-NuRD complex activity-driven increased expression of oncogenic metabolic hubs, contributing to glycolytic shift and extracellular matrix remodeling, and establishing an inflammatory tumor microenvironment. …”

The MsnA stress-response TF is required for the development of <i>A. nidulans.</i> de réir Emmanouil Bastakis (10860279)

“…<p><b>(A)</b> Upper part open reading frame of <i>msnA</i> (AN1652), lower part protein domain analysis and predicted sites for post-translational modifications of MsnA. Blue rectangle = Zink-finger (Cys2His2) domain, purple rectangle = NES (Nuclear Export Signal), red rectangle = NLS (Nuclear Localized Signal), yellow circles = putative phosphosites and green circle = putative ubiquitination site. …”

Data Sheet 3_Pain - related methylation driver genes affect the prognosis of pancreatic cancer patients by altering immune function and perineural infiltration.docx de réir Chencheng Zhang (6877691)

“…</p>Conclusion<p>This study establishes a visceral pain model centered on pancreatic parenchymal nociception rather than secondary neural effects, and for the first time proposes an interconnected regulatory network linking epigenetic modifications, immune reprogramming, and neural plasticity, revealing dual pain pathogenesis mechanisms: (1) immune microenvironment reshaping that potentiates neuroinflammation, and (2) direct ion channel regulation enhancing neuronal excitability. …”

Supplementary file 1_Progress in epigenetic research of breast cancer: a bibliometric analysis since the 2000s.pdf de réir Hua Yang (120668)

“…Recently, research has shifted from traditional genomic analyses to the study of epigenetic regulation, which includes DNA methylation, histone modifications, and non-coding RNAs. Given the rapid expansion of literature in this field, a systematic overview of its evolution and emerging trends is necessary.…”

Data Sheet 1_Immunogenicity risk assessment of peptide-related impurities identified in generic teriparatide products.pdf de réir Aimee E. Mattei (17356099)

“…Regarding product-related impurities, a stated concern is that sequence modifications may create new T-cell epitopes capable of driving unwanted immune responses. …”

Supplementary file 1_Development and Validation of an Indian Nutrition and Food Literacy Tool (INFLOIT) for adolescents.docx de réir Simran Yadav (22613582)

“…</p>Conclusion<p>The INFOLIT is a validated and culturally relevant tool for assessing adolescent NFL and can be adapted for use in various Indian regions and contexts after minor modifications.</p>…”

Table 1_The DIAMONDS intervention for type 2 diabetes for people with severe mental illness: findings from a single-group feasibility study.docx de réir J. V. E. Brown (13116521)

“…This study highlights the feasibility and acceptability of delivering an evaluation of a structured diabetes self-management intervention in people with SMI. Some modifications to study processes will be required before moving to the main RCT, including adjustments to intervention delivery (including more flexibility in the timing of intervention sessions and coach training to improve confidence in supporting the use of a mobile app), data collection processes, and intervention fidelity assessment for the RCT, to enhance adherence and accommodating the complex needs of this population. …”

Presentation 1_FGF2 supports NANOG expression via pyruvate dehydrogenase–dependent histone acetylation under low oxygen conditions.pdf de réir Petr Fojtík (10014185)

“…Protein levels and post-translational modifications were analyzed by Western blotting and quantitative PCR, relative metabolite concentrations by LC–MS, and ROS levels by fluorescence microscopy.…”

Supplementary file 2_Design and validation of a mixed reality workflow for structural cardiac procedures in interventional cardiology.docx de réir Jan Hecko (22604450)

“…</p>Methods<p>The system was built using Unity with modifications to the UnityVolumeRendering plugin for Digital Imaging and Communications in Medicine (DICOM) data processing and volume rendering, Mixed Reality Toolkit (MRTK) for user interactions, and Photon Unity Networking (PUN2) for multi-user synchronization. …”

Supplementary file 4_Progress in epigenetic research of breast cancer: a bibliometric analysis since the 2000s.xlsx de réir Hua Yang (120668)

“…Recently, research has shifted from traditional genomic analyses to the study of epigenetic regulation, which includes DNA methylation, histone modifications, and non-coding RNAs. Given the rapid expansion of literature in this field, a systematic overview of its evolution and emerging trends is necessary.…”

Supplementary file 1_Branched tetrameric lactoferricin peptides modified with diaminopropionic acid exhibit potent antimicrobial and wound-healing activities.docx de réir Nikitha Vavilthota (22760294)

“…The branched tetrameric LfcinB-derived peptide (LBT; (RRWQWR)₄K₂Ahx₂-C₂) is particularly attractive, as its multivalent architecture enhances antimicrobial potency and provides a tunable branching core for structural modifications.</p>Methods<p>In this study, three novel tetrameric variants were designed by substituting the L-lysine branching residues in LBT with non-natural lysine derivatives to alter motif orientation and linker flexibility. …”

Table 9_Analysis of phosphomotifs coupled to phosphoproteome and interactome unveils potential human kinase substrate proteins in SARS-CoV-2.xlsx de réir Vineetha Shaji (21626417)

“…</p>Discussion and Conclusions<p>This study presents a framework for predicting human kinases of specific SARS-CoV-2 protein phosphosites by integrating kinase specificity, virus–host interactions, and post-translational modifications. MAP2K1 was identified as a key host kinase, showing stronger interactions than SRPK1, and is proposed as an antiviral drug target for repurposing in SARS-CoV-2 infections.…”

Precise Modulation of Donor–Acceptor Spatial Configuration and Excited-State Energy Alignment for Efficient Red-Shifted TADF Emitters de réir BoHua Zhang (19564477)

“…A series of emitters (<b>6(7)-PXZ-FQ</b> and <b>6(7)-MeODPA-FQ</b>) were designed, wherein <b>6-PXZ-FQ</b> and <b>6-MeODPA-FQ</b> achieved emission peaks at 654 and 618 nm, respectively, demonstrating significant bandgap narrowing via D–A distance compression. Structural modifications concurrently enhanced ICT strength and transition dipole moments, inducing red-shifted emission while maintaining high photoluminescence quantum yields. …”

Table 2_Normal adrenocorticotropic hormone levels do not exclude adrenal insufficiency during immune checkpoint inhibitor therapy: evidence from clinical, steroid, and structural a... de réir Yuria Ishibashi (22459657)

“…Gel filtration chromatography identified high-molecular-weight ACTH forms in the preserved group, suggesting altered proopiomelanocortin processing or post-translational modifications that impaired ACTH bioactivity.</p>Conclusions<p>Adrenal insufficiency may occur when plasma ACTH levels remain within or above the normal range. …”

Table 6_Pain - related methylation driver genes affect the prognosis of pancreatic cancer patients by altering immune function and perineural infiltration.xlsx de réir Chencheng Zhang (6877691)

“…</p>Conclusion<p>This study establishes a visceral pain model centered on pancreatic parenchymal nociception rather than secondary neural effects, and for the first time proposes an interconnected regulatory network linking epigenetic modifications, immune reprogramming, and neural plasticity, revealing dual pain pathogenesis mechanisms: (1) immune microenvironment reshaping that potentiates neuroinflammation, and (2) direct ion channel regulation enhancing neuronal excitability. …”

Table 1_High-intensity interval training versus moderate-intensity continuous training for polycystic ovary syndrome: a meta-analysis of randomized controlled trials.docx de réir Yi Zhao (14034)

“…Objective<p>Polycystic Ovary Syndrome (PCOS) is the most prevalent endocrine disorder affecting women of reproductive age. Lifestyle modifications, particularly exercise, are cornerstone management strategies, with High-Intensity Interval Training (HIIT) and Moderate-Intensity Continuous Training (MICT) being commonly recommended modalities. …”

Table 8_Analysis of phosphomotifs coupled to phosphoproteome and interactome unveils potential human kinase substrate proteins in SARS-CoV-2.xlsx de réir Vineetha Shaji (21626417)

“…</p>Discussion and Conclusions<p>This study presents a framework for predicting human kinases of specific SARS-CoV-2 protein phosphosites by integrating kinase specificity, virus–host interactions, and post-translational modifications. MAP2K1 was identified as a key host kinase, showing stronger interactions than SRPK1, and is proposed as an antiviral drug target for repurposing in SARS-CoV-2 infections.…”

Presentation 2_FGF2 supports NANOG expression via pyruvate dehydrogenase–dependent histone acetylation under low oxygen conditions.pdf de réir Petr Fojtík (10014185)

“…Protein levels and post-translational modifications were analyzed by Western blotting and quantitative PCR, relative metabolite concentrations by LC–MS, and ROS levels by fluorescence microscopy.…”