Image 2_Role of histone-lysine N-methyltransferase 2D (KMT2D) in MEK-ERK signaling-mediated epigenetic regulation: a phosphoproteomics perspective.jpeg 著者: Sreeshma Ravindran Kammarambath (22637144)

“…Among these, post-translational modifications, especially phosphorylation, serve as an essential regulator, fine-tuning KMT2D stability, localization and functional interactions for maintaining cellular homeostasis. …”

Data Sheet 1_Modified life’s essential 8 mediate the correlation between dietary index for gut microbiota and sleep disorders.docx 著者: Juanjuan Fang (413481)

“…We used restricted cubic spline (RCS) models to evaluate relationships between dose and response, and subgroup analyses to explore effect modifications. We used mediation analysis to assess the intermediary role of mLE8 (Modified Life’s Essential 8) and all its components.…”

Summary of Participant Characteristics. 著者: Stefania Fatone (3834499)

“…Socket comfort score (SCS) was assessed during static fitting of the diagnostic socket before (initial) and after (final) any modifications were made by the prosthetist. Difference scores for comfort and timing were calculated for each pair of casts within prosthetist. …”

Mean (SD) Fabrication Time by Group. 著者: Stefania Fatone (3834499)

“…Socket comfort score (SCS) was assessed during static fitting of the diagnostic socket before (initial) and after (final) any modifications were made by the prosthetist. Difference scores for comfort and timing were calculated for each pair of casts within prosthetist. …”

S1 File - Production of recombinant D-allulose 3-epimerase utilizing an auto-induction approach in fermentor cultures suitable for industrial application 著者: Kenny Lischer (21688679)

“…Images were captured using a mobile phone positioned above a white lightbox, without any modifications in brightness, contrast, or cropping. Lane M corresponds to the protein marker, while lane 1 represents the purified fraction of Ap DAEase. …”

Charge Redistribution via d–p Hybridization in NiCoP Supported on Ni_<b>5</b>P_<b>4</b> Boosts Alkaline Hydrogen Production 著者: Junjie Hu (383516)

“…COMSOL simulations, X-ray photoelectron spectroscopy (XPS), and density functional theory (DFT) calculations reveal that the heterointerface activates covalent Ni/Co–P bonding through optimized d–p orbital hybridization, leading to favorable electron density redistribution and an upshifted d-band center (Δ<i>E</i> = 0.061 eV). These electronic modifications synergistically enhance OH^– adsorption energetics and accelerate water dissociation kinetics. …”

Feasibility of novel Head And Trunk Control Rehabilitation (HATCoRe) device on children with developmental delays 著者: Shristi Shakya (17845031)

“…Five experts evaluated device’s user-friendliness and suggested modifications. Five children (TD and AD) underwent exercises to test parameters like, head lift attempts, sustenance time, preferred auditory and visual stimuli, reaction time, enjoyment, and comfort. …”

Data Sheet 1_Multi-omics analysis and metastasis risk factor prediction in N1b stage PTMC: insights into immune infiltration and therapeutic implications.docx 著者: Hao Dai (4277254)

“…Genomic profiling was employed to investigate mutations, copy number alterations, and methylation modifications in signature genes, followed by screening of antineoplastic drugs and docking simulations to explore their therapeutic potential. …”

Altered mitochondrial DNA methylation in blood in individuals with mild cognitive impairment 著者: Wuzi Tu (22109088)

“…<p>Previous studies reported that altered mitochondrial methylation in Alzheimer’s disease (AD), however, whether epigenetic modifications in mitochondrial genomes contribute to preclinical AD remains unclear. …”

PRISMA flow chart of the screening process. 著者: Prince Ojuka (22404143)

“…The results indicate that several plant-derived molecules effectively inhibit snake venom/toxin targets <i><i>in vitro</i></i> and <i><i>in vivo</i></i>; however, only a few appear suitable for drug development without further modifications. Among the analyzed compounds, the terpenes labdane lactone and labdane trialdehyde, along with the benzenoid anisic acid, exhibited strong antivenom potential. …”

EWAS in COPD by biomass-burning smoke exposure identifies low levels of endothelin-1 by hypermethylation of EDN1 著者: Salvador García-Carmona (20580797)

“…Hypermethylation of the cg08450425 site (<i>EDN1</i>) is significant in women with COPD and associated with low endothelin-1 levels.</p> <p>DNA modifications not present in the sequence contribute to COPD in women exposed to biomass-burning smoke.…”

Data Sheet 1_tRNA-derived small RNA 3’ tRF-Ala CGC obstructs NK cytotoxicity via cleavage of membrane protein MICA in colorectal cancer.docx 著者: Jing Zhang (23775)

“…MICA undergoes post-translational modifications that regulate their expression as they are called membrane-bound MICA (mMICA) at the cancer cell surface. mMICA is a ligand that induces the activation of NK cells. …”

Evaluation of the 10-Item CPIB for PPA (Fegter et al., 2025) 著者: Ollie Fegter (22386822)

“…</p><p dir="ltr"><b>Conclusions: </b>Initial data support use of the CPIB with persons with PPA and their communication partners for capturing clinically meaningful communication function. Potential modifications for sharpening the relevance, applicability, and sensitivity to longitudinal measurement of change include increasing the number of response levels, adding an item on communicative participation via phone/videochat, and using proctored administration for persons with PPA.…”

SLUR(M)-py: a SLURM powered Pythonic pipeline for parallel processing of 3D (Epi)genomic profiles 著者: Cullen Roth (748141)

“…<p>Epigenomics has become multi-faceted, with researchers exploring chromatin structure, nucleosome states, and epigenetic modifications, producing large, complex multi-omic datasets. …”

<b>PathoBiocheModelling to manage Unknowns in Neurodevelopmental Cofactor Disorders</b> 著者: Yuliya Buinitskaya (8680986)

“…Patients A, B and C are 4 to 5 year old boys from different families and towns with similar symptoms of NDD.We modelled their molecular pathogenesis in order to normalize their metabolismthrough personalized biomedical interventions such as dietary modifications, nutritional supplements, and lifestyle adjustments.…”

Computational AlphaFold3 models of NapM monomer, dimers, and complexes with DNA and DivIVA from <i>Mycobacterium smegmatis</i> 著者: Kornel Milcarz (22578815)

“…</p><p><br></p><p dir="ltr">No manual modifications, molecular dynamics refinements, or energy minimizations were performed after prediction.…”

Table 1_Associations of physical activity type, intensity, and frequency with subclinical hypothyroidism: a cross-sectional analysis of NHANES 2007–2012.docx 著者: Zeyu Li (4371955)

“…Curve fitting and threshold effect analyses were conducted to explore potential non-linear relationships, while subgroup analyses examined effect modifications by demographic and clinical factors.</p>Results<p>Among 6,133 participants included in the final analysis (approximately 20.15% of the total NHANES sample), the prevalence of SCH was 2.5%. …”

<b>Global surface ocean fCO2 from CSIR-ML6 (v2025)</b> 著者: Laique M Djeutchouang (9127349)

“…<p dir="ltr">The CSIR-ML6-v2025 revises the original CSIR-ML6 method by Gregor et al. (2019), extending the monthly CO2 data product through December 15, 2024. The following modifications have been implemented:</p><ul><li>SOCAT-v2025 is now used.…”

CEP14^HYP1,2 could not be detected in AWFs by targeted mass spectrometry. 著者: Jakub Rzemieniewski (22290940)

“…<p>A) List of synthetic CEP4 and CEP14 peptide variants, including amino acid sequences, Pro hydroxylation modifications (HYP), and precursor mass-to-charge (m/z) values used for targeted MS analysis. …”

Data Sheet 1_Elevated TyG-BMI significantly increases the 1-year stroke recurrence risk in patients with acute ischemic stroke and hypertension.docx 著者: Yan Liu (25061)

“…Sex-specific stratified analyses were performed to explore potential effect modifications.</p>Results<p>Among 1,620 enrolled patients (39.6% women; mean age 65.2 ± 11.5 years), elevated TyG-BMI was significantly associated with increased 1-year stroke recurrence risk after adjusting for potential confounding factors (hazard ratio [HR]=1.06, 95% confidence interval [CI]: 1.01–1.11, P = 0.032). …”