بدائل البحث:
justifications » notifications (توسيع البحث), purifications (توسيع البحث), certifications (توسيع البحث)
justification » purification (توسيع البحث), certification (توسيع البحث)
notification » notifications (توسيع البحث), certification (توسيع البحث), purification (توسيع البحث)
justifications » notifications (توسيع البحث), purifications (توسيع البحث), certifications (توسيع البحث)
justification » purification (توسيع البحث), certification (توسيع البحث)
notification » notifications (توسيع البحث), certification (توسيع البحث), purification (توسيع البحث)
-
5041
Supplementary file 1_Branched tetrameric lactoferricin peptides modified with diaminopropionic acid exhibit potent antimicrobial and wound-healing activities.docx
منشور في 2025"…The branched tetrameric LfcinB-derived peptide (LBT; (RRWQWR)<sub>4</sub>K<sub>2</sub>Ahx<sub>2</sub>-C<sub>2</sub>) is particularly attractive, as its multivalent architecture enhances antimicrobial potency and provides a tunable branching core for structural modifications.</p>Methods<p>In this study, three novel tetrameric variants were designed by substituting the L-lysine branching residues in LBT with non-natural lysine derivatives to alter motif orientation and linker flexibility. …"
-
5042
Table 9_Analysis of phosphomotifs coupled to phosphoproteome and interactome unveils potential human kinase substrate proteins in SARS-CoV-2.xlsx
منشور في 2025"…</p>Discussion and Conclusions<p>This study presents a framework for predicting human kinases of specific SARS-CoV-2 protein phosphosites by integrating kinase specificity, virus–host interactions, and post-translational modifications. MAP2K1 was identified as a key host kinase, showing stronger interactions than SRPK1, and is proposed as an antiviral drug target for repurposing in SARS-CoV-2 infections.…"
-
5043
Precise Modulation of Donor–Acceptor Spatial Configuration and Excited-State Energy Alignment for Efficient Red-Shifted TADF Emitters
منشور في 2025"…A series of emitters (<b>6(7)-PXZ-FQ</b> and <b>6(7)-MeODPA-FQ</b>) were designed, wherein <b>6-PXZ-FQ</b> and <b>6-MeODPA-FQ</b> achieved emission peaks at 654 and 618 nm, respectively, demonstrating significant bandgap narrowing via D–A distance compression. Structural modifications concurrently enhanced ICT strength and transition dipole moments, inducing red-shifted emission while maintaining high photoluminescence quantum yields. …"
-
5044
Table 2_Normal adrenocorticotropic hormone levels do not exclude adrenal insufficiency during immune checkpoint inhibitor therapy: evidence from clinical, steroid, and structural a...
منشور في 2025"…Gel filtration chromatography identified high-molecular-weight ACTH forms in the preserved group, suggesting altered proopiomelanocortin processing or post-translational modifications that impaired ACTH bioactivity.</p>Conclusions<p>Adrenal insufficiency may occur when plasma ACTH levels remain within or above the normal range. …"
-
5045
Table 6_Pain - related methylation driver genes affect the prognosis of pancreatic cancer patients by altering immune function and perineural infiltration.xlsx
منشور في 2025"…</p>Conclusion<p>This study establishes a visceral pain model centered on pancreatic parenchymal nociception rather than secondary neural effects, and for the first time proposes an interconnected regulatory network linking epigenetic modifications, immune reprogramming, and neural plasticity, revealing dual pain pathogenesis mechanisms: (1) immune microenvironment reshaping that potentiates neuroinflammation, and (2) direct ion channel regulation enhancing neuronal excitability. …"
-
5046
Table 1_High-intensity interval training versus moderate-intensity continuous training for polycystic ovary syndrome: a meta-analysis of randomized controlled trials.docx
منشور في 2025"…Objective<p>Polycystic Ovary Syndrome (PCOS) is the most prevalent endocrine disorder affecting women of reproductive age. Lifestyle modifications, particularly exercise, are cornerstone management strategies, with High-Intensity Interval Training (HIIT) and Moderate-Intensity Continuous Training (MICT) being commonly recommended modalities. …"
-
5047
Table 8_Analysis of phosphomotifs coupled to phosphoproteome and interactome unveils potential human kinase substrate proteins in SARS-CoV-2.xlsx
منشور في 2025"…</p>Discussion and Conclusions<p>This study presents a framework for predicting human kinases of specific SARS-CoV-2 protein phosphosites by integrating kinase specificity, virus–host interactions, and post-translational modifications. MAP2K1 was identified as a key host kinase, showing stronger interactions than SRPK1, and is proposed as an antiviral drug target for repurposing in SARS-CoV-2 infections.…"
-
5048
Presentation 2_FGF2 supports NANOG expression via pyruvate dehydrogenase–dependent histone acetylation under low oxygen conditions.pdf
منشور في 2025"…Protein levels and post-translational modifications were analyzed by Western blotting and quantitative PCR, relative metabolite concentrations by LC–MS, and ROS levels by fluorescence microscopy.…"
-
5049
Data Sheet 1_The DIAMONDS intervention for type 2 diabetes for people with severe mental illness: findings from a single-group feasibility study.pdf
منشور في 2025"…This study highlights the feasibility and acceptability of delivering an evaluation of a structured diabetes self-management intervention in people with SMI. Some modifications to study processes will be required before moving to the main RCT, including adjustments to intervention delivery (including more flexibility in the timing of intervention sessions and coach training to improve confidence in supporting the use of a mobile app), data collection processes, and intervention fidelity assessment for the RCT, to enhance adherence and accommodating the complex needs of this population. …"
-
5050
Table 2_Pain - related methylation driver genes affect the prognosis of pancreatic cancer patients by altering immune function and perineural infiltration.xlsx
منشور في 2025"…</p>Conclusion<p>This study establishes a visceral pain model centered on pancreatic parenchymal nociception rather than secondary neural effects, and for the first time proposes an interconnected regulatory network linking epigenetic modifications, immune reprogramming, and neural plasticity, revealing dual pain pathogenesis mechanisms: (1) immune microenvironment reshaping that potentiates neuroinflammation, and (2) direct ion channel regulation enhancing neuronal excitability. …"
-
5051
Table 10_Analysis of phosphomotifs coupled to phosphoproteome and interactome unveils potential human kinase substrate proteins in SARS-CoV-2.xlsx
منشور في 2025"…</p>Discussion and Conclusions<p>This study presents a framework for predicting human kinases of specific SARS-CoV-2 protein phosphosites by integrating kinase specificity, virus–host interactions, and post-translational modifications. MAP2K1 was identified as a key host kinase, showing stronger interactions than SRPK1, and is proposed as an antiviral drug target for repurposing in SARS-CoV-2 infections.…"
-
5052
Display the effects of (a) pitch [
منشور في 2025"…Refractive index changes in PCF are usually the cause of action for PCF-based biosensors. These modifications have an impact on how light travels within the fiber. …"
-
5053
Supplementary file 3_Progress in epigenetic research of breast cancer: a bibliometric analysis since the 2000s.xlsx
منشور في 2025"…Recently, research has shifted from traditional genomic analyses to the study of epigenetic regulation, which includes DNA methylation, histone modifications, and non-coding RNAs. Given the rapid expansion of literature in this field, a systematic overview of its evolution and emerging trends is necessary.…"
-
5054
Table 3_Pain - related methylation driver genes affect the prognosis of pancreatic cancer patients by altering immune function and perineural infiltration.xlsx
منشور في 2025"…</p>Conclusion<p>This study establishes a visceral pain model centered on pancreatic parenchymal nociception rather than secondary neural effects, and for the first time proposes an interconnected regulatory network linking epigenetic modifications, immune reprogramming, and neural plasticity, revealing dual pain pathogenesis mechanisms: (1) immune microenvironment reshaping that potentiates neuroinflammation, and (2) direct ion channel regulation enhancing neuronal excitability. …"
-
5055
Image 1_Normal adrenocorticotropic hormone levels do not exclude adrenal insufficiency during immune checkpoint inhibitor therapy: evidence from clinical, steroid, and structural a...
منشور في 2025"…Gel filtration chromatography identified high-molecular-weight ACTH forms in the preserved group, suggesting altered proopiomelanocortin processing or post-translational modifications that impaired ACTH bioactivity.</p>Conclusions<p>Adrenal insufficiency may occur when plasma ACTH levels remain within or above the normal range. …"
-
5056
Table 1_Effects of vegetation restoration on soil fungi community structure and assembly process in a semiarid alpine mining region.docx
منشور في 2025"…Moreover, artificial restoration induced substantial modifications in soil fungal community composition. Taxonomic analysis demonstrated a distinct shift in dominant specialist species from Ascomycota in unrestored, natural plant, and 2-year restoration sites to Glomeromycota in 6-year restoration sites. …"
-
5057
Can the intensive care requirement score improve triage at the emergency department for acutely intoxicated patients?
منشور في 2025"…Eligibility criteria were similar to those used in the original derivation study, with modifications appropriate for the emergency department setting. …"
-
5058
Table 1_High-dose medium-term HMB supplementation did not trigger body composition changes in trained and untrained males under usual conditions or high-intensity functional exerci...
منشور في 2025"…</p>Discussion<p>The individually adjusted high HMB dose did not change body mass and composition in trained or untrained individuals during a three-week exclusive supplementation or three-week supplementation in combination with additional HIFT stimuli. Therefore, any modifications in this area may likely require a longer treatment period.…"
-
5059
Display the effects of (a) pitch [
منشور في 2025"…Refractive index changes in PCF are usually the cause of action for PCF-based biosensors. These modifications have an impact on how light travels within the fiber. …"
-
5060
Display the effects of (a) pitch [
منشور في 2025"…Refractive index changes in PCF are usually the cause of action for PCF-based biosensors. These modifications have an impact on how light travels within the fiber. …"