Identification of narciclasine as a novel NRF2 inhibitor by Hoang Hai Ngo (20564072)

“…<p>Cancer genome sequencing studies have identified somatic mutations in the KEAP1/NRF2 pathway. In an effort to identify novel NRF2 small molecule inhibitor(s), we have screened a natural compound library comprising 1330 chemicals in A549-ARE-GFP-luciferase cells and identified that narciclasine significantly inhibits NRF2-dependent luciferase activity. …”

Table 1_Correlation between changes of amino acid spectrum and alopecia in patients with obesity undergoing bariatric surgery: a prospective cohort study.docx by Tingwen Wang (3927815)

“…</p>Results<p>Among 67 patients analyzed, LSG significantly decreased serum concentrations of arginine, alanine, threonine, glutamic acid, branched-chain amino acids (valine, isoleucine, leucine), and aromatic amino acids (tyrosine, phenylalanine, tryptophan) (p < 0.05), while serine and glycine increased (p < 0.05). …”

Data Sheet 1_Effects of Ophiopogon japonicus oligosaccharides on type 2 diabetes in rats via modulation of gut microbiota and metabolites.docx by Tingyu Yang (10686507)

“…Serum untargeted metabolomic analysis revealed that OJO modulated 40 diabetes-associated metabolites, primarily linked to the synthesis and metabolic pathways of aromatic amino acids and bile acids. Correlation analysis identified significant connections between these metabolic alterations and specific gut microbiota.…”

Image 1_Snowmelt seepage fluxes of dissolved organic matter in forest and grassland – a molecular-level case study from the Hainich Critical Zone Exploratory, Germany.pdf by Chen Huang (202847)

“…Forest seepage showed a pronounced DOM flux peak and synchronous increases in the relative abundances of aromatic DOM components, indicating surface-derived transport of plant litter carbon. …”

Data Sheet 1_Dose-dependent effects of biochar amendment on early rice seedling growth and nursery substrate properties in Southern China.pdf by Liming Chen (113761)

“…Conversely, the 40% and 50% treatments had inhibitory effects, resulting in significant reductions in seedling leaf length, stem base width (decreased by 24.9%), dry weight, and leaf area. Root fresh weight also decreased by 11.9%–17.1%. …”

Table 1_Cannabidiol reduces synaptic strength and neuronal firing in layer V pyramidal neurons of the human cortex with drug-resistant epilepsy.docx by Vladimir A. Martinez-Rojas (21758372)

“…At the cellular level, whole-cell patch-clamp recordings showed that CBD decreased the excitability of layer V pyramidal neurons, as evidenced by changes in the somatic input resistance, the membrane time constant, the hyperpolarization-induced “sag” conductance, the rheobase current needed to elicit an action potential, and the firing discharge in response to depolarizing current steps. …”

JAK/STAT signaling promotes high global translation rates in CySCs. by Ruoxu Wang (9312306)

“…(C, C′) A wild-type testis showing highest OPP in CySCs adjacent to the hub and decreasing OPP levels with increasing distance from the hub. …”

Data Sheet 1_Recognition and localization of ratoon rice rolled stubble rows based on monocular vision and model fusion.docx by Yuanrui Li (4156645)

“…</p>Methods<p>In order to realize automatic navigation of the righting machine, a method of fusing an instance segmentation model and a monocular depth prediction model was used to realize monocular localization of the rolled rice stubble rows in this study.…”

Supplementary file 1_Early life microbiome disbalance impacts neuroendocrine outcomes in pre-pubertal mice in a sexually dimorphic manner.zip by Bistra B. Nankova (21576839)

“…Maternal antibiotics during nursing caused: (1) microbial dysbiosis in the offspring as evident by markedly enlarged ceca, no detectable by-products of bacterial fermentation (sp. SCFA) and dramatic changes in microbial composition, diversity (reduced - alpha Chao1and beta Bray-Curtis, as compared to their respective controls) and predictive metabolic activity; (2) alteration in the transcriptional signature of the adrenal medullae and attenuated peripheral stress responses in male offspring, associated with gap junction signaling pathways; (3) increased anxiety-like testing metrics, and decreased locomotor activity; all in a sexually dimorphic manner.…”

data-raw.xls by Jinlei Zhu (19952964)

“…Sap flow velocity and daily sap flow accumulation increased at 50% stumping but decreased at 75% and 100% stumping. Stumping altered the relationships between sap flow velocity and meteorological factors, with the correlation coefficient between these variables decreasing as the degree of stumping increased. …”

Scale and environmental data for the analysis of year class growth of coregonids from Lake Starnberg by Maxim Teichert (20796416)

“…During the observed period, phosphorus concentrations decreased, indicating reduced nutrient availability, whereas spring temperatures showed no significant long-term trend. …”

Table 1_Dual variants of uncertain significance in a case of hyper-IgM syndrome: implications for diagnosis and management.docx by Nourhen Agrebi (14151222)

“…Background<p>Hyper-IgM syndrome (HIGM) is a genetic immunodeficiency characterized by elevated to normal IgM levels and decreased IgG, IgA, and IgE. The overlapping clinical presentations of different gene mutations complicate diagnosis and management.…”

Data Sheet 1_Dual variants of uncertain significance in a case of hyper-IgM syndrome: implications for diagnosis and management.pdf by Nourhen Agrebi (14151222)

“…Background<p>Hyper-IgM syndrome (HIGM) is a genetic immunodeficiency characterized by elevated to normal IgM levels and decreased IgG, IgA, and IgE. The overlapping clinical presentations of different gene mutations complicate diagnosis and management.…”

Table 1_Transcriptome analysis reveals regulatory mechanism of methyl jasmonate-induced monoterpenoid biosynthesis in Mentha arvensis L..xlsx by Tingting Huang (496866)

“…(M. arvensis) is an aromatic plant of the Mentha genus, renowned for its medicinal and economic importance. …”

Data Sheet 1_Investigation of the physiological and molecular regulatory mechanism of soluble sugar metabolism in Lavandula angustifolia Mill. under cold stress.docx by Yuchen Liang (8596404)

“…<p>Lavender (Lavandula angustifolia Mill.) is a valuable aromatic plant with significant commercial importance. …”

Supporting information Abou-Kandil et al. by Olaf Kniemeyer (8561361)

“…Both antifungals induced significantly increased levels of proteins involved in aromatic acid metabolism, transmembrane transport and secondary metabolite biosynthesis. …”

Data Sheet 2_Transcriptome analysis reveals regulatory mechanism of methyl jasmonate-induced monoterpenoid biosynthesis in Mentha arvensis L..pdf by Tingting Huang (496866)

“…(M. arvensis) is an aromatic plant of the Mentha genus, renowned for its medicinal and economic importance. …”

Data Sheet 1_Transcriptome analysis reveals regulatory mechanism of methyl jasmonate-induced monoterpenoid biosynthesis in Mentha arvensis L..pdf by Tingting Huang (496866)

“…(M. arvensis) is an aromatic plant of the Mentha genus, renowned for its medicinal and economic importance. …”

Data Sheet 4_Transcriptome analysis reveals regulatory mechanism of methyl jasmonate-induced monoterpenoid biosynthesis in Mentha arvensis L..pdf by Tingting Huang (496866)

“…(M. arvensis) is an aromatic plant of the Mentha genus, renowned for its medicinal and economic importance. …”

Data Sheet 5_Transcriptome analysis reveals regulatory mechanism of methyl jasmonate-induced monoterpenoid biosynthesis in Mentha arvensis L..pdf by Tingting Huang (496866)

“…(M. arvensis) is an aromatic plant of the Mentha genus, renowned for its medicinal and economic importance. …”