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Computational approach to unravel the impact of missense mutations of proteins (D2HGDH and IDH2) causing D-2-hydroxyglutaric aciduria 2.
Published 2018“…In the case of D2HGDH protein, the mutations I147S and V444A that are positioned in the beta sheet region exhibited higher Root Mean Square Deviation (RMSD), decrease in compactness and number of intramolecular hydrogen bonds compared to the mutations N439D and D375Y that are positioned in the turn and loop region, respectively. …”
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A computational model to predict the structural and functional consequences of missense mutations in O6-methylguanine DNA methyltransferase
Published 2019“…Considering true positives, true negatives, false positives, and false negatives, three mutations (Y114E, R128G, and C145A) showed "loss of DNA repair activity," and were analyzed further using molecular dynamics simulations (MDS) using GROMACS for 50ns. …”
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Abnormal brain structure and behavior in MyD88-deficient mice.
Published 2020“…Our data indicate a pathophysiological significance of MyD88 for mammalian CNS development, structure, and function.…”
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Transcriptome assembly, profiling and differential gene expression analysis of the halophyte Suaeda fruticosa provides insights into salt tolerance
Published 2015“…Conclusions This work has identified potential genes involved in salt tolerance in Suaeda fruticosa, and has provided an outline of tools to use for de novo transcriptome analysis. The assemblies that were used provide coverage of a considerable proportion of the transcriptome, which allows analysis of differential gene expression and identification of genes that may be involved in salt tolerance. …”
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Spectral and Structural Properties of High-Quality Reduced Graphene Oxide Produced via a Simple Approach Using Tetraethylenepentamine
Published 2022“…This was further confirmed by the XRD analysis, which showed a clear decrease in the d-spacing, caused by the removal of oxygenated groups during the reduction reaction.…”
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Impact of fines type on gas flow using 3D micro-computed tomography
Published 2019“…Therefore, there is a need to model and quantify fines impact on multi-phase flow using 3D reconstruction to better understand gas recovery systems. …”
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Impact of fines type on gas flow using 3D micro-computed tomography
Published 2019“…Therefore, there is a need to model and quantify fines impact on multi-phase flow using 3D reconstruction to better understand gas recovery systems. …”
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25-Hydroxyvitamin D serum levels inversely correlate to disease severity and serum C-reactive protein levels in patients with hidradenitis suppurativa
Published 2021“…Subsequently, Guillet et al.5 described an association between vitamin D deficiency and HS severity, also reporting a significant decrease of the inflammatory nodules in patients supplemented with vitamin D. …”
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Regulation of NKG2D by RKIP: Implications on NK-mediated cytotoxicity and cytokine production
Published 2021“…Studies have suggested that RKIP can be used therapeutically to augment the proapoptotic tendencies in tumor cells, regulate the epithelial-mesenchymal transition (EMT), and decrease metastasis. NKG2D is a C-lectin-type receptor of the NK cell. …”
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A novel index based on planktonic copepod reproductive traits as a tool for marine ecotoxicology studies
Published 2020“…At high concentrations, cadmium and silver induce an increase in EPR in the copepods Acartia tonsa and Acartia hudsonica, while exposure to mercury decreases EPR in adults by 50%. All three metals affect HS, with mercury inducing a stronger effect than cadmium and silver. …”
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Vitamin D status affects proteomic profile of HDL-associated proteins and inflammatory mediators in dyslipidemia
Published 2024“…Our findings indicated a decrease in HDL-associated apolipoproteins (ApoM and ApoD) in individuals with both dyslipidemia and vitamin D deficiency. …”
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Inhibition of p90 ribosomal S6 kinase potentiates cisplatin activity in A549 human lung adenocarcinoma cells
Published 2020“…Results: The combination of cisplatin and BI-D1870 potentiated the antimigration rate, the activation of caspases-3 and was associated with a significant decrease in RSK1 and ERK expression when compared to cisplatin alone. …”
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The global burden of cancer attributable to risk factors, 2010–19: a systematic analysis for the Global Burden of Disease Study 2019
Published 2022“…MethodsThe GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk–outcome pairs were included on the basis of the World Cancer Research Fund criteria. …”
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A computational approach for investigating the mutational landscape of RAC-alpha serine/threonine-protein kinase (AKT1) and screening inhibitors against the oncogenic E17K mutation...
Published 2019“…Our predictions revealed that E17K, R67W, V164G, E319G, R391G, D32Y, L52H, L52R, and W80R were the most pathogenic mutations. …”
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Appropriateness of gentamicin therapeutic drug monitoring at a Middle Eastern tertiary hospital setting: a retrospective evaluation and quality audit
Published 2024“…Objective: This study aimed to evaluate the appropriateness of gentamicin therapeutic drug monitoring (TDM) at a tertiary care hospital in Qatar. Methods: A one-year quantitative retrospective chart review of all gentamicin TDM records was conducted. …”
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Erratum: ITRAQ-based Quantitative Protein Expression Profiling and MRM Verification of Markers in Type 2 Diabetes (Journal of Proteome Research (2012) 11 (5527-5537) DOI: 10.1021/p...
Published 2013“…As expected, the diabetic cohort showed an elevation in serum glucose, HbA1c, and insulin levels and a decrease in the serum levels of Vitamin D and HDL .Addition/Correctionpubs.acs.org/jpr © 2013 American Chemical Society 1065 dx.doi.org/10.1021/pr4000224 | J. …”
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