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latest decrease » largest decrease (Expand Search), greatest decrease (Expand Search), largest decreases (Expand Search)
large increase » large increases (Expand Search), marked increase (Expand Search)
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Kit-mediated autophagy suppression driven by a viral oncoprotein emerges as a crucial survival mechanism in Merkel cell carcinoma
Published 2025“…</p> <p><b>Abbreviation</b>: 3-MA, 3-methyladenine; AL, autolysosome; AP, autophagosome; Baf-A1, bafilomycin A<sub>1</sub>; BARA, β-α repeated autophagy specific domain; BH3, BCL2 homology 3 domain; CCD, coiled-coil domain; CHX, cycloheximide; Co-IP, co-immunoprecipitation; CQ, chloroquine; CTR, control; DAPI, 4′,6-diamidino-2-phenylindole; EBSS, Earle’s balanced salt solution; ECD, evolutionarily conserved domain; EEE, three-tyrosine phosphomimetic mutations Y229E Y233E Y352E; ER, endoplasmic reticulum; FFF, three-tyrosine non-phosphomimetic mutations; FFPE, formalin-fixed paraffin-embedded; FL, full-length; GIST, gastrointestinal stromal tumor; IB, immunoblotting; IHC, immunohistochemistry; KIT-HEK293, KIT stably expressing HEK293 cells; KRT20/CK20, keratin 20; LT, large T-antigen; LT339, MCPyV truncated LT antigen; LTco, codon-optimized MCPyV LT antigen; MCC, Merkel cell carcinoma; MCPyV<sup>−</sup>, MCPyV-negative; MCPyV, Merkel cell polyomavirus; MCPyV<sup>+</sup>, MCPyV-positive; PARP1, poly(ADP-ribose) polymerase 1; PCI, pan-caspase inhibitor; PI, propidium iodide; PtdIns3K, class III phosphatidylinositol 3-kinase; PtdIns3P, phosphatidylinositol-3-phosphate; RB1, RB transcriptional corepressor 1; RTKs, receptor tyrosine kinases; KITLG/SCF, KIT ligand; sT, small T-antigen; sTco, codon-optimized MCPyV sT antigen; T-B, Tat-BECN1; T-S, Tat-scrambled; TEM, transmission electron microscopy.…”
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DataSheet_1_Year-round foraging across large spatial scales suggest that bowhead whales have the potential to adapt to climate change.pdf
Published 2023“…Our findings suggest that, compared to related species (e.g., right whales), bowheads forage at relatively low rates and over a large geographic area throughout the year. This suggests that bowhead whales have the potential to adjust their behaviours (e.g., increased time allocated to feeding) and shift their distributions (e.g., occupy higher latitude foraging grounds) to adapt to climate-change induced environmental conditions. …”
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CY-09 Alleviates the Depression-like Behaviors via Inhibiting NLRP3 Inflammasome-Mediated Neuroinflammation in Lipopolysaccharide-Induced Mice
Published 2022“…Depression is a serious mental illness, mainly characterized as large mood swings and sleep, diet, and cognitive function disorders. …”
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Table1_RAB39B as a Chemosensitivity-Related Biomarker for Diffuse Large B-Cell Lymphoma.DOCX
Published 2022“…<p>Background: Diffuse large B-cell lymphoma (DLBCL) is the most common aggressive lymphoma with an increased tendency to relapse or refractoriness. …”
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Large and Pressure-Dependent <i>c-</i>Axis Piezoresistivity of Highly Oriented Pyrolytic Graphite near Zero Pressure
Published 2024“…The <i>c-</i>axis piezoresistivity of microscale highly oriented pyrolytic graphite (HOPG) is found to show a large value of 5.68 × 10<sup>–5</sup> kPa<sup>–1</sup> near zero pressure and decreases by 2 orders of magnitude to the established value of ∼10<sup>–7</sup> kPa<sup>–1</sup> when the pressure increases to 200 MPa. …”
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Data_Sheet_1_A Healthy Lifestyle Offsets the Increased Risk of Childhood Obesity Caused by High Birth Weight: Results From a Large-Scale Cross-Sectional Study.PDF
Published 2021“…</p><p>Methods: Participants were selected from a large-scale cross-sectional study conducted in the seven provinces across China. …”
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