Fibrillar form of α-synuclein-specific scFv antibody inhibits α-synuclein seeds induced aggregation and toxicity حسب Gupta, Vijay

"…To overcome this issue, we engineered single-chain variable fragments (scFvs) against fibrillar α-syn, a putative disease-relevant form of α-syn. …"
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Pharmacoeconomic Evaluations of Oral Anticancer Agents. Thematic Systematic Review حسب Alkadour, Ahmad Amer

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The Impact of Pamam Dendrimers on Her2-Positive Breast Cancer and the Early Stages of Embryogenesis حسب Kheraldine, Hadeel

"…Cationic G6 PAMAMs significantly decreased the viability of HER2-positive breast cancer cell lines down to 5.1% in SK-BR3 and to 5.7% in ZR-75 cells (p<0.001), in a dose and time-dependent fashion. …"
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NADPH-derived ROS generation drives fibrosis and endothelial-to-mesenchymal transition in systemic sclerosis: Potential cross talk with circulating miRNAs حسب Posadino, Anna Maria

"…Sera from SSc patients showed significant changes in the expression of a set of fibrosis/EndMT-associated microRNAs (miRNA), including miR-21, miR-92a, miR-24, miR-27b, miR-125b, miR-29c, and miR-181b, which resulted significantly upregulated as compared to healthy donors sera. …"
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Dynamic Distributed Multi-Path Aided Load Balancing for Optical Data Center Networks حسب Wang, Fu

"…This paper establishes a leaf-spine Hoe-DCN model to illustrate the principal characteristic of dynamic load balancing in TOR switches for the first time. …"
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Therapeutic outcomes and biodistribution of gold nanoparticles in collagen-induced arthritis animal model حسب Nehal E., Abdel-Hakem

"…The role of gold nanoparticles (AuNPs) in the treatment of autoimmune diseases remains mysterious. Therefore, we investigated the effect of AuNPs on collagen-induced arthritis (CIA) and the impact of particle size on the tissue distribution of AuNPs. …"
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Reactive Absorption of CO2 Using Ethylaminoethanol Promoted Aqueous Potassium Carbonate Solvent حسب Bhosale, Rahul Rambhau

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Functional characterization of human myosin-binding protein C3 variants associated with hypertrophic cardiomyopathy reveals exon-specific cardiac phenotypes in zebrafish model حسب Da'as, Sahar I.

"…MYBPC3 variants genotype–phenotype associations remain poorly understood. We investigated the impact of two novel human MYBPC3 splice-site variants: V1: c.654+2_654+4dupTGG targeting exon 5 using morpholino MOe5i5; and V2: c.772+1G'A targeting exon 6 using MOe6i6; located within C1 domain of cMyBP-C protein, known to be critical in regulating sarcomere structure and contractility. …"
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The Effect of Hyperoxia on Central and Peripheral Factors of Arm Flexor Muscles Fatigue Following Maximal Ergometer Rowing in Men حسب Volianitis, Stefanos

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Montmorency tart cherry supplementation does not impact sleep, body composition, cellular health, or blood pressure in healthy adults حسب Hillman, Angela R.

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Inhibition of alpha-synuclein seeded fibril formation and toxicity by herbal medicinal extracts. حسب Ardah, Mustafa T

"…In order to investigate the inhibitory mechanisms of these two compounds towards fibril formation, we demonstrated that salvianolic acid B binds predominantly to monomers, while dihydromyricetin binds to oligomeric species and to a lower extent to monomers. …"
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Novel, selective EPO receptor ligands lacking erythropoietic activity reduce infarct size in acute myocardial infarction in rats حسب Kiss, K.

"…In a pilot study, EPO at 100 U/mL significantly decreased cell death compared to vehicle (33.8 ± 2.3% vs. 40.3 ± 1.5%, p < 0.05) in rat neonatal cardiomyocytes subjected to simulated ischemia/reperfusion. …"
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Impact of SARS-CoV-2 on Ambient Air Quality in Northwest China (NWC) حسب Zaib, Shah

"…To prevent the spread of the SARS-CoV-2 outbreak, China imposed a countrywide lockdown that significantly improved the air quality. …"
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Chronic melatonin treatment improves obesity by inducing uncoupling of skeletal muscle SERCA-SLN mediated by CaMKII/AMPK/PGC1α pathway and mitochondrial biogenesis in female and ma... حسب Salagre, D.

"…Melatonin acute treatment limits obesity of young Zücker diabetic fatty (ZDF) rats by non-shivering thermogenesis (NST). We recently showed melatonin chronically increases the oxidative status of vastus lateralis (VL) in both obese and lean adult male animals. …"
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Impact Assessment of Land Use Planning on Travel Behavior in Doha, Qatar حسب Zaina, Samar

"…In the last decade Qatar has witnessed a rapid growth in its economic and industrial sector as a result of oil and gas economies. …"
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Applying value-based strategies to accelerate access to novel cancer medications: guidance from the Oncology Health Economics Expert Panel in Qatar (Q-OHEP) حسب Hamad, Anas

"…Background: In line with global trends, cancer incidence and mortality may have decreased for specific types of cancer in Qatar. However, the cancer-related burden on patients, healthcare systems, and the economy is expected to expand; thus, cancer remains a significant public healthcare issue in Qatar. …"
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Changes in the burden and underlying causes of heart failure in the Eastern Mediterranean Region, 1990–2019: an analysis of the Global Burden of Disease Study 2019 حسب Razieh, Hassannejad

"…MethodsWe used the 2019 Global Burden of Disease (GBD) data for estimates of prevalence, years lived with disability (YLDs), and underlying causes of HF in the EMR. …"
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Reversal of insulin resistance in overweight and obese subjects by trans-resveratrol and hesperetin combination—link to dysglycemia, blood pressure, dyslipidemia, and low-grade inf... حسب Rabbani, Naila

"…These correlations were not present with placebo. tRES-HESP decreased low-grade inflammation, characterized by decreased expression of CCL2, COX-2, IL-8, and RAGE. …"
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Transcriptome assembly, profiling and differential gene expression analysis of the halophyte Suaeda fruticosa provides insights into salt tolerance حسب Diray-Arce, Joann

"…However, little is known about the genes involved in salt tolerance. We have characterized the transcriptome of Suaeda fruticosa, a halophyte that has the ability to sequester salts in its leaves. …"
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The Association between Zinc and Copper and Cardiometabolic Risk Factors in Adults حسب Al Kudsi, Dana Samir

"…This investigated the association between CMR factors and the status of Zn, Cu, and Zn/Cu ratio. A total of 575 Qatari adults (?18 years) were obtained from Qatar Biobank. …"
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