Supplementary file 1_CYLD as a key regulator of myocardial infarction-to-heart failure transition revealed by multi-omics integration.docx by Jingya Xu (5572547)

“…Our multistep analytical pipeline included weighted gene coexpression network analysis (WGCNA) to map interacting genes, machine learning algorithms for robust classification, functional annotation via Kyoto Encyclopedia of Genes and Genomes (KEGG) to explore biological pathways, CIBERSORT correlation analysis linking hub genes with immune cell states, transcriptional regulation profiling of key hubs, and single-cell sequencing to assess the functional relevance of these hubs.…”

Data Sheet 1_Multi-omics exploration of chaperone-mediated immune-proteostasis crosstalk in vascular dementia and identification of diagnostic biomarkers.xlsx by Wentong Li (492392)

“…Biomarker validation was performed through cross-validation using LASSO, SVM-RFE, and Random Forest algorithms. Immune microenvironment analysis was conducted using CIBERSORT, while single-cell transcriptomics was analyzed within the Seurat framework.…”

Data Sheet 5_Multi-omics exploration of chaperone-mediated immune-proteostasis crosstalk in vascular dementia and identification of diagnostic biomarkers.csv by Wentong Li (492392)

“…Biomarker validation was performed through cross-validation using LASSO, SVM-RFE, and Random Forest algorithms. Immune microenvironment analysis was conducted using CIBERSORT, while single-cell transcriptomics was analyzed within the Seurat framework.…”

Supplementary file 1_Multi-omics exploration of chaperone-mediated immune-proteostasis crosstalk in vascular dementia and identification of diagnostic biomarkers.docx by Wentong Li (492392)

“…Biomarker validation was performed through cross-validation using LASSO, SVM-RFE, and Random Forest algorithms. Immune microenvironment analysis was conducted using CIBERSORT, while single-cell transcriptomics was analyzed within the Seurat framework.…”

Data Sheet 2_Multi-omics exploration of chaperone-mediated immune-proteostasis crosstalk in vascular dementia and identification of diagnostic biomarkers.xlsx by Wentong Li (492392)

“…Biomarker validation was performed through cross-validation using LASSO, SVM-RFE, and Random Forest algorithms. Immune microenvironment analysis was conducted using CIBERSORT, while single-cell transcriptomics was analyzed within the Seurat framework.…”

Data Sheet 3_Multi-omics exploration of chaperone-mediated immune-proteostasis crosstalk in vascular dementia and identification of diagnostic biomarkers.xlsx by Wentong Li (492392)

“…Biomarker validation was performed through cross-validation using LASSO, SVM-RFE, and Random Forest algorithms. Immune microenvironment analysis was conducted using CIBERSORT, while single-cell transcriptomics was analyzed within the Seurat framework.…”

Data Sheet 4_Multi-omics exploration of chaperone-mediated immune-proteostasis crosstalk in vascular dementia and identification of diagnostic biomarkers.xlsx by Wentong Li (492392)

“…Biomarker validation was performed through cross-validation using LASSO, SVM-RFE, and Random Forest algorithms. Immune microenvironment analysis was conducted using CIBERSORT, while single-cell transcriptomics was analyzed within the Seurat framework.…”

Consensus group. by Yinghao Ren (17915291)

“…We also identified differentially expressed genes (DEGs) within the clusters and between SLE patients and healthy controls. …”

GSVA pathway. by Yinghao Ren (17915291)

“…We also identified differentially expressed genes (DEGs) within the clusters and between SLE patients and healthy controls. …”

Hallmark significant GSVA results. by Yinghao Ren (17915291)

“…We also identified differentially expressed genes (DEGs) within the clusters and between SLE patients and healthy controls. …”

RBP table. by Yinghao Ren (17915291)

“…We also identified differentially expressed genes (DEGs) within the clusters and between SLE patients and healthy controls. …”

Enrichment analysis of GO. by Yinghao Ren (17915291)

“…We also identified differentially expressed genes (DEGs) within the clusters and between SLE patients and healthy controls. …”

Differential gene expression analysis results. by Yinghao Ren (17915291)

“…We also identified differentially expressed genes (DEGs) within the clusters and between SLE patients and healthy controls. …”

The flowchart of this study. by Yinghao Ren (17915291)

“…We also identified differentially expressed genes (DEGs) within the clusters and between SLE patients and healthy controls. …”

DGIdb. by Yinghao Ren (17915291)

“…We also identified differentially expressed genes (DEGs) within the clusters and between SLE patients and healthy controls. …”

Glucocorticoid related genes. by Yinghao Ren (17915291)

“…We also identified differentially expressed genes (DEGs) within the clusters and between SLE patients and healthy controls. …”

CIBERSORTx results. by Yinghao Ren (17915291)

“…We also identified differentially expressed genes (DEGs) within the clusters and between SLE patients and healthy controls. …”

Differential gene expression analysis results. by Yinghao Ren (17915291)

“…We also identified differentially expressed genes (DEGs) within the clusters and between SLE patients and healthy controls. …”

GSEA result. by Yinghao Ren (17915291)

“…We also identified differentially expressed genes (DEGs) within the clusters and between SLE patients and healthy controls. …”

Enrichment analysis of GO. by Yinghao Ren (17915291)

“…We also identified differentially expressed genes (DEGs) within the clusters and between SLE patients and healthy controls. …”