Data Sheet 2_Behavioral and biochemical changes associated with the analgesic effects of (2R,6R)-hydroxynorketamine alone and in combination with meloxicam following disk puncture... by Vaskar Das (21529538)

“…</p>Results<p>Prior to disk puncture paw withdrawal thresholds were 3.44 ± 0.51 g before surgery and were reduced to 0.54 ± 0.38 g at day 7 without a difference by sex; however, sex-specific responses were evident in other behavioral outcomes. EC₅₀ estimates for (2R,6R)-Hydroxynorketamine were 14.2 mg/kg (95% CI: 10.3 mg/kg to 19.7 mg/kg) in male and 16.9 mg/kg (95% CI: 12.8 mg/kg to 22.3 mg/kg) in female mice (P < 0.637). (2R,6R)-Hydroxynorketamine plus meloxicam enhanced the analgesic effect on the AUC_0−3d of meloxicam alone. (2R,6R)-Hydroxynorketamine analgesia was associated with increases in Glutamate receptor A1 & A2, p-Kv2.1, p-CaMKII and reduced BDNF protein ratios in the hippocampus, attenuated c-Fos in the spinal cord, and decreased BDNF at the dorsal root ganglion (DRG).…”

Data Sheet 1_Behavioral and biochemical changes associated with the analgesic effects of (2R,6R)-hydroxynorketamine alone and in combination with meloxicam following disk puncture... by Vaskar Das (21529538)

“…</p>Results<p>Prior to disk puncture paw withdrawal thresholds were 3.44 ± 0.51 g before surgery and were reduced to 0.54 ± 0.38 g at day 7 without a difference by sex; however, sex-specific responses were evident in other behavioral outcomes. EC₅₀ estimates for (2R,6R)-Hydroxynorketamine were 14.2 mg/kg (95% CI: 10.3 mg/kg to 19.7 mg/kg) in male and 16.9 mg/kg (95% CI: 12.8 mg/kg to 22.3 mg/kg) in female mice (P < 0.637). (2R,6R)-Hydroxynorketamine plus meloxicam enhanced the analgesic effect on the AUC_0−3d of meloxicam alone. (2R,6R)-Hydroxynorketamine analgesia was associated with increases in Glutamate receptor A1 & A2, p-Kv2.1, p-CaMKII and reduced BDNF protein ratios in the hippocampus, attenuated c-Fos in the spinal cord, and decreased BDNF at the dorsal root ganglion (DRG).…”

Data Sheet 3_Behavioral and biochemical changes associated with the analgesic effects of (2R,6R)-hydroxynorketamine alone and in combination with meloxicam following disk puncture... by Vaskar Das (21529538)

“…</p>Results<p>Prior to disk puncture paw withdrawal thresholds were 3.44 ± 0.51 g before surgery and were reduced to 0.54 ± 0.38 g at day 7 without a difference by sex; however, sex-specific responses were evident in other behavioral outcomes. EC₅₀ estimates for (2R,6R)-Hydroxynorketamine were 14.2 mg/kg (95% CI: 10.3 mg/kg to 19.7 mg/kg) in male and 16.9 mg/kg (95% CI: 12.8 mg/kg to 22.3 mg/kg) in female mice (P < 0.637). (2R,6R)-Hydroxynorketamine plus meloxicam enhanced the analgesic effect on the AUC_0−3d of meloxicam alone. (2R,6R)-Hydroxynorketamine analgesia was associated with increases in Glutamate receptor A1 & A2, p-Kv2.1, p-CaMKII and reduced BDNF protein ratios in the hippocampus, attenuated c-Fos in the spinal cord, and decreased BDNF at the dorsal root ganglion (DRG).…”

Data Sheet 10_Behavioral and biochemical changes associated with the analgesic effects of (2R,6R)-hydroxynorketamine alone and in combination with meloxicam following disk puncture... by Vaskar Das (21529538)

“…</p>Results<p>Prior to disk puncture paw withdrawal thresholds were 3.44 ± 0.51 g before surgery and were reduced to 0.54 ± 0.38 g at day 7 without a difference by sex; however, sex-specific responses were evident in other behavioral outcomes. EC₅₀ estimates for (2R,6R)-Hydroxynorketamine were 14.2 mg/kg (95% CI: 10.3 mg/kg to 19.7 mg/kg) in male and 16.9 mg/kg (95% CI: 12.8 mg/kg to 22.3 mg/kg) in female mice (P < 0.637). (2R,6R)-Hydroxynorketamine plus meloxicam enhanced the analgesic effect on the AUC_0−3d of meloxicam alone. (2R,6R)-Hydroxynorketamine analgesia was associated with increases in Glutamate receptor A1 & A2, p-Kv2.1, p-CaMKII and reduced BDNF protein ratios in the hippocampus, attenuated c-Fos in the spinal cord, and decreased BDNF at the dorsal root ganglion (DRG).…”

Image 6_Behavioral and biochemical changes associated with the analgesic effects of (2R,6R)-hydroxynorketamine alone and in combination with meloxicam following disk puncture in mi... by Vaskar Das (21529538)

“…</p>Results<p>Prior to disk puncture paw withdrawal thresholds were 3.44 ± 0.51 g before surgery and were reduced to 0.54 ± 0.38 g at day 7 without a difference by sex; however, sex-specific responses were evident in other behavioral outcomes. EC₅₀ estimates for (2R,6R)-Hydroxynorketamine were 14.2 mg/kg (95% CI: 10.3 mg/kg to 19.7 mg/kg) in male and 16.9 mg/kg (95% CI: 12.8 mg/kg to 22.3 mg/kg) in female mice (P < 0.637). (2R,6R)-Hydroxynorketamine plus meloxicam enhanced the analgesic effect on the AUC_0−3d of meloxicam alone. (2R,6R)-Hydroxynorketamine analgesia was associated with increases in Glutamate receptor A1 & A2, p-Kv2.1, p-CaMKII and reduced BDNF protein ratios in the hippocampus, attenuated c-Fos in the spinal cord, and decreased BDNF at the dorsal root ganglion (DRG).…”

Image 5_Behavioral and biochemical changes associated with the analgesic effects of (2R,6R)-hydroxynorketamine alone and in combination with meloxicam following disk puncture in mi... by Vaskar Das (21529538)

“…</p>Results<p>Prior to disk puncture paw withdrawal thresholds were 3.44 ± 0.51 g before surgery and were reduced to 0.54 ± 0.38 g at day 7 without a difference by sex; however, sex-specific responses were evident in other behavioral outcomes. EC₅₀ estimates for (2R,6R)-Hydroxynorketamine were 14.2 mg/kg (95% CI: 10.3 mg/kg to 19.7 mg/kg) in male and 16.9 mg/kg (95% CI: 12.8 mg/kg to 22.3 mg/kg) in female mice (P < 0.637). (2R,6R)-Hydroxynorketamine plus meloxicam enhanced the analgesic effect on the AUC_0−3d of meloxicam alone. (2R,6R)-Hydroxynorketamine analgesia was associated with increases in Glutamate receptor A1 & A2, p-Kv2.1, p-CaMKII and reduced BDNF protein ratios in the hippocampus, attenuated c-Fos in the spinal cord, and decreased BDNF at the dorsal root ganglion (DRG).…”

Data_Sheet_1_Effects of COVID-19-targeted non-pharmaceutical interventions on pediatric hospital admissions in North Italian hospitals, 2017 to 2022: a quasi-experimental study int... by Giuseppe Maglietta (12992976)

“…Level change for Mental Disorders significantly decreased during school closure (HRR 0.50, 95%CI 0.30–0.82) but increased during mitigation measures by 28% (HRR 1.28, 95%CI 0.98–1.69).…”

Data Sheet 1_Behavioral and biochemical changes associated with the analgesic effects of (2R,6R)-hydroxynorketamine alone and in combination with meloxicam following disk puncture... by Vaskar Das (21529538)

“…</p>Results<p>Prior to disk puncture paw withdrawal thresholds were 3.44 ± 0.51 g before surgery and were reduced to 0.54 ± 0.38 g at day 7 without a difference by sex; however, sex-specific responses were evident in other behavioral outcomes. EC₅₀ estimates for (2R,6R)-Hydroxynorketamine were 14.2 mg/kg (95% CI: 10.3 mg/kg to 19.7 mg/kg) in male and 16.9 mg/kg (95% CI: 12.8 mg/kg to 22.3 mg/kg) in female mice (P < 0.637). (2R,6R)-Hydroxynorketamine plus meloxicam enhanced the analgesic effect on the AUC_0−3d of meloxicam alone. (2R,6R)-Hydroxynorketamine analgesia was associated with increases in Glutamate receptor A1 & A2, p-Kv2.1, p-CaMKII and reduced BDNF protein ratios in the hippocampus, attenuated c-Fos in the spinal cord, and decreased BDNF at the dorsal root ganglion (DRG).…”

Data Sheet 4_Behavioral and biochemical changes associated with the analgesic effects of (2R,6R)-hydroxynorketamine alone and in combination with meloxicam following disk puncture... by Vaskar Das (21529538)

“…</p>Results<p>Prior to disk puncture paw withdrawal thresholds were 3.44 ± 0.51 g before surgery and were reduced to 0.54 ± 0.38 g at day 7 without a difference by sex; however, sex-specific responses were evident in other behavioral outcomes. EC₅₀ estimates for (2R,6R)-Hydroxynorketamine were 14.2 mg/kg (95% CI: 10.3 mg/kg to 19.7 mg/kg) in male and 16.9 mg/kg (95% CI: 12.8 mg/kg to 22.3 mg/kg) in female mice (P < 0.637). (2R,6R)-Hydroxynorketamine plus meloxicam enhanced the analgesic effect on the AUC_0−3d of meloxicam alone. (2R,6R)-Hydroxynorketamine analgesia was associated with increases in Glutamate receptor A1 & A2, p-Kv2.1, p-CaMKII and reduced BDNF protein ratios in the hippocampus, attenuated c-Fos in the spinal cord, and decreased BDNF at the dorsal root ganglion (DRG).…”

School Food Authority Survey III on Supply Chain Disruption and Student Participation by USDA FNS Office of Policy Support (17484222)

“…</p><p><br></p><p dir="ltr">In addition, the file contains weights created to produce national estimates for the SY 2023-24 Survey on Supply Chain Challenges and Student Participation.…”

<i>Rab23</i> deletion perturbs ciliation in a context-dependent manner. by Wan Ying Leong (22075947)

“…Similar to actin-CKO mice, neural progenitor cell-specific <i><i>Rab23</i></i> knockout mutants show dramatically decreased number of ciliated neurons in the cerebral cortex of the animals. …”

Table_1_Construction of a risk screening and visualization system for pulmonary nodule in physical examination population based on feature self-recognition machine learning model.X... by Fang Tian (360682)

“…The feature self-recognition machine learning model further highlighted age, smoking or passive smoking, high psychological stress, occupational exposure, chronic lung diseases, family history of lung cancer, decreased albumin levels, and elevated carcinoembryonic antigen as key predictors for early pulmonary nodule risk, demonstrating superior performance.…”

Absolute β convergence results. by Ke Liu (121889)

“…The kernel density estimation method and Markov chain model were used to conduct the study. …”

Renamed 05c60. by Hongjun Sun (12554742)

“…Using machine splitting and location assignment technology, the Dagum Gini coefficient and its decomposition methods, and traditional and spatial Markov chain estimation methods, we identify the spatiotemporal disparities and dynamic transition characteristics of the contribution levels to national standard development across China’s eight comprehensive economic zones. …”

Table 1_Epidemic of lower extremity peripheral arterial disease in China: current trends and future prediction.docx by Jianxing Yu (3558050)

“…Due to its often asymptomatic nature, PAD is frequently overlooked. We aimed to estimate the disease burden of PAD in China over the past 30 years and to project future trends over the next 25 years.…”

Image 1_Epidemic of lower extremity peripheral arterial disease in China: current trends and future prediction.tif by Jianxing Yu (3558050)

“…Due to its often asymptomatic nature, PAD is frequently overlooked. We aimed to estimate the disease burden of PAD in China over the past 30 years and to project future trends over the next 25 years.…”

Data Sheet 1_The impact of environmental contaminants, air pollution, and social deprivation on childhood leukemia survival in California.docx by Fernando Hernandez (22801319)

“…Five-year survival analyses were performed using Kaplan-Meier estimators and Cox proportional hazards ratio (HR) models with 95% confidence intervals (CI), adjusting for individual socio-demographic and clinical prognostic factors.…”

Region Division. by Hongjun Sun (12554742)

“…Using machine splitting and location assignment technology, the Dagum Gini coefficient and its decomposition methods, and traditional and spatial Markov chain estimation methods, we identify the spatiotemporal disparities and dynamic transition characteristics of the contribution levels to national standard development across China’s eight comprehensive economic zones. …”

Data Sheet 1_Impact of multiple environmental factors on influenza–like illness in Fujian Province, China, 2015–2023: a multicity study.zip by Xiaoyan Yao (8723622)

“…Our results indicated that the combined cumulative effect of average temperature on ILI across nine cities decreased with rising temperatures, with a risk peak at −0.1°C. …”

Presentation 1_Global, regional, and national burden of cardiovascular disease attributable to high body mass index from 1990 to 2021 and projection to 2045.pptx by Hui Li (32376)

“…</p>Methods<p>We used data from the Global Burden of Disease Study (GBD) 2021 to estimate CVD deaths and disability-adjusted life years (DALYs) attributable to HBMI. …”