Loss of Lsd1 in long bone mesenchymal cells leads to impaired ossification and growth. حسب Petri Rummukainen (4247122)

"…(F) RT-PCR analysis of RNA extracted from marrow-evacuated bone shows efficiency of <i>Lsd1</i> knockout (~60%), decrease in osteoblast markers <i>Osx</i>, <i>Runx2</i> and <i>Col1A1</i>, no significant change of osteoblast marker <i>Trap</i> and adipocyte marker <i>PPARgamma</i>, and a significant increase of <i>AdipoQ</i> expression. …"