Supplemental Movie 5 from The FOXM1 Inhibitor RCM-1 Decreases Carcinogenesis and Nuclear β-Catenin حسب Samriddhi Shukla (321547)

The result of molecular dynamics simulation. حسب Ashraf Attia Mahmoud (21262201)

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Extraction of demaging missense mutations from the TCGA Database. حسب Ashraf Attia Mahmoud (21262201)

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Structural alterations in hydrogen bond networks of the TP53 protein caused by mutations G266E (A-B), G105C (C-D), R273C (E-F), R280G (G-H), and Q136P (I-J). حسب Ashraf Attia Mahmoud (21262201)

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(A) The distribution of mutations within the 3D structure of the TP53 protein. حسب Ashraf Attia Mahmoud (21262201)

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The result of the secondary structure prediction of native and six mutant proteins of TP35 protein using the SOPMA server. حسب Ashraf Attia Mahmoud (21262201)

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Graph illustrating the distribution of mutations across 20 genes. حسب Ashraf Attia Mahmoud (21262201)

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Molecular dynamics simulation results for Apo-TP53 (red), wild-typeTP53. حسب Ashraf Attia Mahmoud (21262201)

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Effect of mutations on protein stability predicted by I-MUTANT 2.0, MUpro and CUPSAT. حسب Ashraf Attia Mahmoud (21262201)

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P53 mutant docking results (HDOCK and pyDOCK servers). حسب Ashraf Attia Mahmoud (21262201)

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Oncogenic Classification of TP53 missense mutations. حسب Ashraf Attia Mahmoud (21262201)

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Computational analysis of missense mutations using PhD-SNP, PANTHER and, SNPs&GO. حسب Ashraf Attia Mahmoud (21262201)

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Redocking results showing the interaction between the TP53 protein (white ribbon) and its DNA dodecamer ligand (magenta and blue) from PDB ID: 2AC0, highlighting the binding confor... حسب Ashraf Attia Mahmoud (21262201)

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The table shows the significant and non-significant altered group with different parameters. حسب Ashraf Attia Mahmoud (21262201)

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Result of the phenotypic analysis. حسب Ashraf Attia Mahmoud (21262201)

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Oncogenic nature of mutations predicted using CScape and CScape-somatic. حسب Ashraf Attia Mahmoud (21262201)

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(A) Pie chart showing the distribution of mutation types identified within the TP53 gene. حسب Ashraf Attia Mahmoud (21262201)

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Structural clashes in TP53 mutants: (A) G266E mutation causes steric clashes with PHE109 and LEU257, destabilizing the structure. حسب Ashraf Attia Mahmoud (21262201)

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(A) TP53 expression levels are elevated in TP53-mutant and nonmutant HNSC samples compared to normal tissues. حسب Ashraf Attia Mahmoud (21262201)

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Type of Mutations. حسب Ashraf Attia Mahmoud (21262201)

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