The optimal cytosolic occupancy increases with metabolic pathway length <i>N</i> and decreasing external nutrient concentration <i>s</i>_ext. by Tin Yau Pang (8756325)

Reuse of paths within years (i.e., their thickness, a proxy for the directedness of movement) decreased in response to wildfire despite an increase in overall number of paths. by Aishwarya Subramanian (14930268)

Tissue, days post-infection (dpi) and the top 10 most significant genes with increased and decreased expression with valid gene symbols for the response contrasts. by Gillian P. McHugo (8965919)

Spatial information of excitatory neurons in APP/PS1 mice are decreased in dCA1 and vCA1. by Udaysankar Chockanathan (18510288)

Increasing network size does not guarantee convergence to a balanced state. by Pierre Ekelmans (15470955)

“…The balanced state predicts a linear solution for the <i>N</i> → ∞ limit (Eq S1 in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1011097#pcbi.1011097.s003" target="_blank">S1 Text</a>, dashed line). …”

Elevation and latitude drives structure and tree species composition in Andean forests: Results from a large-scale plot network by Agustina Malizia (459844)

Increasing gaps and decreasing returns attenuate spending effects. by William Minozzi (8564712)

Table_1_Validation of GWAS-Identified Variants for Anti-TNF Drug Response in Rheumatoid Arthritis: A Meta-Analysis of Two Large Cohorts.docx by Jose Manuel Sánchez-Maldonado (11611801)

Large benefits to youth-focused HIV treatment-as-prevention efforts in generalized heterosexual populations: An agent-based simulation model - Fig 2 by John E. Mittler (8138499)

“…</b> To account for existing treatment, we assume a linear increase in the number of people receiving suppressive therapy beginning nine years before the TasP campaign. …”

Data Sheet 1_Cytotoxic CD4+ T-follicular cells may mediate killing against lymphoma cells.pdf by Yin Xiao (447102)

“…In this study, we aim to elucidate their presence and functional relevance in two different lymphoma subtypes, follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL). Flow cytometric analysis of tonsillar versus FL-cell suspensions revealed a heightened number of GZMK⁺NKG7/TIA-1⁺ T_F_K cells in the latter, accompanied by a significant increase in T-regulatory and T-follicular regulatory (T_FR) cells. …”

nsP4-C483Y or Q192L mutations decrease sensitivity to 4′-FlU. by Peiqi Yin (6533747)

Average self-reported physical health ratings before or during the COVID-19 pandemic among individuals who engaged during the pandemic in more than 3 (A), 4 (B), or 5 (C) positive... by Elie Mulhem (22537863)

Subjects:

Method for the Large-Scale Synthesis of Multifunctional 1,4-Dihydro-pyrrolo[3,2‑<i>b</i>]pyrroles by Mariusz Tasior (1457731)

Method for the Large-Scale Synthesis of Multifunctional 1,4-Dihydro-pyrrolo[3,2‑<i>b</i>]pyrroles by Mariusz Tasior (1457731)

<b>Warming alters plankton body-size distributions in a large field experiment</b> by Dania Albini (20288463)

“…<br><br>Experimental Design: The study took place at the Silwood Park Mesocosm Facility in southeast England (Lat: 51.410250, Long: -0.638620, Ascot, UK, Fig. S1) as part of a long-term warming experiment. Ninety-six 2000L mesocosms (1m deep, 1.6m wide) were arranged in a 12x8 grid, with treatments randomly assigned within four 3x8 blocks. …”

(a) Measuring device; (b) Measuring method. by Chenhao Li (822769)

“…Although increasing SHMP content improved the early strength, it led to a decrease in later strength, with the maximum late strength observed at 2% SHMP. …”

Discovery of an <i>In Vivo</i> Chemical Probe for BCL6 Inhibition by Optimization of Tricyclic Quinolinones by Alice C. Harnden (15197268)

“…B-cell lymphoma 6 (BCL6) is a transcriptional repressor and oncogenic driver of diffuse large B-cell lymphoma (DLBCL). …”

Discovery of an <i>In Vivo</i> Chemical Probe for BCL6 Inhibition by Optimization of Tricyclic Quinolinones by Alice C. Harnden (15197268)

“…B-cell lymphoma 6 (BCL6) is a transcriptional repressor and oncogenic driver of diffuse large B-cell lymphoma (DLBCL). …”

DataSheet_1_Exploring blood lipids-immunity associations following HBV vaccination: evidence from a large cross-sectional study.pdf by Qian Yang (300330)

“…Conversely, higher levels of the triglyceride to HDL (TG/HDL) ratio (OR, 0.90; 95% CI, 0.84-0.98), total cholesterol to HDL (Chol/HDL) ratio (OR, 0.77; 95% CI, 0.64-0.92), and low-density lipoprotein to HDL (LDL/HDL) ratio (OR, 0.85; 95% CI, 0.76-0.96) were associated with a decreased likelihood of seroprotection.</p>Conclusion<p>This study suggests that lipid levels may play a role in modulating the immune response following HBV vaccination.…”

Studies with large effect sizes tend to have low samples sizes. by Jeff C. Clements (9161831)