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20861
Table 3_Therapeutic potential of luteolin in central precocious puberty: insights from a danazol-induced rat model.xlsx
Published 2025“…Finally, we carried out enzyme-linked immunosorbent assay (ELISA) and reverse transcription- quantitative polymerase chain reaction (RT-qPCR) for finding validation and exploring the underlying mechanisms.</p>Results<p>In the danazol-induced CPP model, luteolin treatment significantly decreased the abundances of Estradiol (E2), luteinizing hormone serum, and follicle-stimulating hormone in sera; reduced organ coefficients and ovarian and uterine wet weights; and delayed vaginal opening. …”
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20862
Supporting data for “<b>Human Lipocalin-2 Variants: Therapeutic Evaluations</b>”
Published 2024“…Using transgenic TG-hLcn2/LKO and global lipocalin-2 knockout (LKO) mouse models, we examined the expression of these lipocalin-2 variants during high-fat dietary exposure and assessed their effects on neutrophil lifespan and phenotype.</p><p dir="ltr">Following a high-fat diet, our findings demonstrated that C87A levels were significantly elevated in cardiac and epididymal white adipose tissue (eWAT). …”
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20863
Table 1_Molecular, biofilm and motility characterization of Acinetobacter baumannii isolated from a neonatal intensive care unit at a children’s hospital in South China.xlsx
Published 2025“…Twitching motility was markedly reduced in ST1959 and also decreased after levofloxacin exposure.</p>Conclusion<p>This NICU outbreak was driven by CRAB ST195 harboring a conserved resistome. …”
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20864
Image 4_Metformin attenuates alveolar bone destruction in mice with apical periodontitis and inhibits pro-inflammatory cytokine synthesis in lipopolysaccharide-stimulated RAW264.7...
Published 2025“…</p>Results<p>Metformin significantly reduced periapical bone destruction on postoperative days 21 and 28, and decreased the number of osteoclasts on the periapical alveolar bone on postoperative day 28. …”
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20865
Data Sheet 1_Evaluation of the epidemiological and economic impact of the ADLIFE intervention on medium- to long-term in patients with advanced chronic disease.pdf
Published 2025“…Emergency visits and consultations with primary care professionals decreased significantly, while specialist consultations increased. …”
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20866
Table2_Identification of telomere-related lncRNAs and immunological analysis in ovarian cancer.xlsx
Published 2024“…Background<p>Ovarian cancer (OC) is a global malignancy characterized by metastatic invasiveness and recurrence. …”
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20867
Data Sheet 1_Global burden of breast cancer and application of patient-reported outcomes in clinical trials: a systematic analysis based on the global burden of disease study 2021...
Published 2025“…Background<p>Breast cancer is one of the most prevalent tumors worldwide, significantly compromising the survival and quality of life of patients. …”
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20868
Data Sheet 1_Individual alpha frequency tACS reduces static functional connectivity across the default mode network.docx
Published 2025“…An additional analysis simulated the influence of the cortical folding on the effect of tACS over FC.</p>Results<p>IAF-tACS significantly decreased sFC in intra- and inter-DMN links in the stimulation group compared to the sham group, with a special influence over antero-posterior links between hubs of the DMN. …”
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20869
Table 1_Oral bacterial community dynamics during induction of gingival inflammation.xlsx
Published 2025“…Multivariate statistical analyses were applied to evaluate microbial dynamics and their associations with clinical outcomes.</p>Results<p>The study revealed pronounced microbial changes, particularly in supragingival plaque, where Leptotrichia and Prevotella increased while Streptococcus decreased. …”
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20870
Table 4_Explainable machine learning reveals ribosome biogenesis biomarkers in preeclampsia risk prediction.xlsx
Published 2025“…Finally, qRT-PCR confirmed the differential expression of key genes in clinical samples.</p>Results<p>We identified 25 ribosome biogenesis-related differentially expressed genes, which were significantly enriched in RNA degradation and rRNA processing. …”
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20871
Table 1_Polygonatum cyrtonema Hua polysaccharides alleviate muscle atrophy and fat lipolysis by regulating the gut microenvironment in chemotherapy-induced cachexia.docx
Published 2025“…Additionally, the agonist of free fatty acid receptor 2 (FFAR2)—a crucial short-chain fatty acid (SCFA) signaling molecule—was used to investigate the role of gut microbiota metabolites, specifically SCFAs, in the treatment of cancer cachexia, with comparisons to PCPs.</p><p>Results: This study demonstrated that PCPs significantly mitigated body weight loss, restored muscle fiber atrophy and mitochondrial disorder, alleviated adipose tissue wasting, strengthened the intestinal barrier integrity, and decreased the intestinal inflammation in chemotherapy-induced cachexia. …”
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20872
Image 2_Metformin attenuates alveolar bone destruction in mice with apical periodontitis and inhibits pro-inflammatory cytokine synthesis in lipopolysaccharide-stimulated RAW264.7...
Published 2025“…</p>Results<p>Metformin significantly reduced periapical bone destruction on postoperative days 21 and 28, and decreased the number of osteoclasts on the periapical alveolar bone on postoperative day 28. …”
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20873
Table1_Identification of telomere-related lncRNAs and immunological analysis in ovarian cancer.docx
Published 2024“…Background<p>Ovarian cancer (OC) is a global malignancy characterized by metastatic invasiveness and recurrence. …”
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20874
Data from: Quantifying seed rain patterns in a remnant and a chronosequence of restored tallgrass prairies in north central Missouri
Published 2025“…<p>Seed rain is an influential process related to plant community diversity, composition, and regeneration. …”
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20875
Table 5_Explainable machine learning reveals ribosome biogenesis biomarkers in preeclampsia risk prediction.xlsx
Published 2025“…Finally, qRT-PCR confirmed the differential expression of key genes in clinical samples.</p>Results<p>We identified 25 ribosome biogenesis-related differentially expressed genes, which were significantly enriched in RNA degradation and rRNA processing. …”
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20876
Data Sheet 1_Molecular insights into Atorvastatin’s role in delaying intervertebral disc degeneration.zip
Published 2025“…Apoptosis within the discs was further examined by electron microscopy.</p>Results<p>Pretreatment with 10 μM atorvastatin significantly improved the survival rate of NPCs exposed to hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) and reduced apoptosis. …”
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20877
Image 1_Fraxin modulates lipid metabolism as well as gut flora to avert NAFLD.tif
Published 2025“…GO and KEGG analyses suggested that fraxin primarily treats NAFLD by modulating lipid metabolism and atherosclerosis-related signaling pathways. In vivo, fraxin significantly lowered liver index and visceral fat accumulation, reduced serum levels of “interleukin-6 (IL-6),” “aspartate aminotransferase,” “tumor necrosis factor-α (TNF-α)” and “alanine aminotransferase,” and decreased hepatic TG content. …”
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20878
Table 2_Explainable machine learning reveals ribosome biogenesis biomarkers in preeclampsia risk prediction.xlsx
Published 2025“…Finally, qRT-PCR confirmed the differential expression of key genes in clinical samples.</p>Results<p>We identified 25 ribosome biogenesis-related differentially expressed genes, which were significantly enriched in RNA degradation and rRNA processing. …”
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20879
Image 2_The alteration of the sensorimotor network in trigeminal neuralgia after microvascular decompression surgery: a follow-up study using independent component analysis.tif
Published 2025“…Introduction<p>Trigeminal neuralgia (TN) is a chronic neuropathic pain disorder characterized by spontaneous or triggered electric shock-like facial pain. …”
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20880
Image 4_A metagenome-wide association study of gut microbiota in hepatitis B virus-related cirrhosis in northwest China.tif
Published 2025“…Shotgun metagenomic sequencing was conducted to analyze gut microbiota taxonomic composition and function.</p>Results<p>HBV-LC patients showed significantly elevated alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), γ-glutamyl transferase (γ-GGT), prothrombin time, international normalized ratio (INR), and thrombin time, but reduced triglycerides (TG), total cholesterol (TC), erythrocytes, thrombocytes, total protein, albumin, and prothrombin time activity (PT-ratio). …”