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significant change » significant changes (Expand Search), significant challenge (Expand Search), significant challenges (Expand Search)
significant cause » significant changes (Expand Search), significant gap (Expand Search), significant increase (Expand Search)
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18721
Table 2_Interaction with IGF1 overrides ANXA2-mediated anti-inflammatory functions of IGFBP5 in vivo.xlsx
Published 2025“…This study explained why it causes opposite effects in different circumstances.…”
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18722
Supplementary file 1_Analysis of microbial composition in different dry skin areas of Beijing women.docx
Published 2025“…At the genus level, the relative abundance of Streptococcus was significantly increased in the dry skin group, whereas a decreasing trend was observed for Cutibacterium. …”
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18723
Soluble average Klotho level as a prognostic marker for acute kidney injury outcomes: a 90-day follow-up study
Published 2025“…Interestingly, we found that sKlotho value was significantly decreased and an alteration in the sKlotho level ran parallel to changes in kidney function in AKI patients. …”
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18724
Glycogen synthase kinase 3 promotes the proliferation of porcine epidemic diarrhoea virus by phosphorylating the nucleocapsid protein
Published 2025“…The phosphorylation level significantly decreased after mutation of threonine (Thr) to serine (Ser). …”
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18725
Data Sheet 1_Refinement of the novel tank diving test: toward standardized and robust analysis of anxiety-like behavior in zebrafish.docx
Published 2025“…We optimized the detection parameters for region entry and freezing behavior using logistic regression analysis, significantly reducing false-positive classifications caused by tracking artifacts. …”
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18726
Table 1_Refrigerator ownership and the nutrition-health trade-off: evidence from Chinese households.docx
Published 2025“…</p>Results<p>Refrigerator ownership significantly increases daily calorie intake by 39.1%. …”
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18727
Cholecalciferol alleviates testicular dysfunction in experimental hyperthyroidism via antioxidant, anti-inflammatory and antiapoptotic effects
Published 2025“…It significantly decreased the levels of serum inflammatory markers and malondialdehyde levels. …”
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18728
Table1_Biomechanical effects of different mandibular movements and torque compensations during mandibular advancement with clear aligners: a finite element analysis.DOCX
Published 2024“…</p>Results<p>When the mandibular advancement was equal to or slightly excessed the occlusal opening distance, stress on the posterior PDL decreased and became more evenly distributed. Increasing the occlusal opening distance significantly raised stress on the posterior PDL and caused grater labial inclination of the mandibular anterior teeth. …”
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18729
Table 1_Epidemiological characteristics and trends of pre-hospital emergency care in Handan, China from 2011 to 2024.docx
Published 2025“…Over the past 14 years, Handan’s pre-hospital EMS demand increased significantly by 3.11-fold (p < 0.001). The percentages of EMS patients aged 61 to 70 and over 71 years old increased significantly (p < 0.01), in contrast, the percentage of EMS patients aged 21 to 30 and 31 to 40 years old decreased significantly (p < 0.01). …”
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18730
Table 1_Guiren Runchang granules alleviate slow transit constipation in mice by modulating gut microbiota and short-chain fatty acids.docx
Published 2025“…Specifically, the relative abundance of the genera Alloprevotella and Muribaculum increased, while that of Prevotellaceae_NK3B31_group, Ruminococcus, and Lachnospiraceae_UCG-001 decreased. These microbiota changes were significantly correlated with SCFAs level, motility-related hormone concentrations, and defecation phenotype. …”
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18731
Figures of manuscript "Fluvoxamine exerts anti-influenza(H1N1) effects through inhibiting apoptosis pathway"
Published 2025“…<i>In vitro</i>, fluvoxamine significantly increased cell survival rate at non-toxic doses [(60.77+4.42) %<i> vs</i> (79.74±5.43) %, <i>P</i>=0.0028] and reduced cell damage caused by H1N1 infection. …”
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18732
CDCP1 regulates CDA and hENT1 expression through c-Src/PKCδ signaling pathway.
Published 2025“…T24-CD cells exhibited increased CDA and decreased hENT1 expression, whereas T24-CDKO cells showed the opposite trend. …”
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18733
DataSheet1_Diphenyl diselenide protects against diabetic kidney disease through modulating gut microbiota dysbiosis in streptozotocin-induced diabetic rats.docx
Published 2024“…</p>Results<p>The results showed DPDS and metformin improved the DKD in STZ rats, as evidenced by decreased blood glucose, BUN, urine volume, urine microalbumin, urinary β2 microglobulin, and improvement of renal pathological morphology. …”
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18734
Table 1_Effects of a community pharmacy-based structured medication review on drug-related problems in all-comers with polypharmacy: a randomized, controlled, double-blind, paralle...
Published 2025“…Therapy adherence- and health literacy-related DRPs decreased significantly by ~60% and ~64%, respectively. …”
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18735
Supplementary Material for: Focus on the Blind Spot of Stone Disease: Analysis of Lower Urinary Tract Stone Interventions from 2006 to 2020 using German nationwide inpatient data.
Published 2024“…Methods We analyzed data from the nationwide German hospital billing database from 2006 to 2020. The significance of changes over time was evaluated via linear regression analysis. …”
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18736
Image 1_Loss of calcium/calmodulin-dependent protein kinase kinase 2, transferrin, and transferrin receptor proteins in the temporal cortex of Alzheimer’s patients postmortem is as...
Published 2024“…</p>Results<p>CAMKK2, TF, and TFRC levels were significantly decreased in AD patients’ temporal cortices compared to CN individuals, independent of age or postmortem interval-related changes. …”
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18737
Table5_Combined administration of catalpol, puerarin, gastrodin, and borneol modulates the Tlr4/Myd88/NF-κB signaling pathway and alleviates microglia inflammation in Alzheimer’s d...
Published 2024“…The results demonstrated that the combined administration of these 4 components (CPGB) had superior mitigating effects on AD cell model, as evidenced by the reduced pro-inflammatory cytokine production and decreased deposition of Aβ protein. Further in vivo and in vitro experiments confirmed that varying doses of CPGB formula effectively ameliorated STZ-induced cognitive deficits, as shown by NOR, MWM, and EMP tests, as well as pathological changes in hippocampal tissues and a 3-dimensional brain neurovascular unit (3D-NVU) model, including decreased deposition of Aβ protein and formation of plaques. …”
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18738
Table4_Combined administration of catalpol, puerarin, gastrodin, and borneol modulates the Tlr4/Myd88/NF-κB signaling pathway and alleviates microglia inflammation in Alzheimer’s d...
Published 2024“…The results demonstrated that the combined administration of these 4 components (CPGB) had superior mitigating effects on AD cell model, as evidenced by the reduced pro-inflammatory cytokine production and decreased deposition of Aβ protein. Further in vivo and in vitro experiments confirmed that varying doses of CPGB formula effectively ameliorated STZ-induced cognitive deficits, as shown by NOR, MWM, and EMP tests, as well as pathological changes in hippocampal tissues and a 3-dimensional brain neurovascular unit (3D-NVU) model, including decreased deposition of Aβ protein and formation of plaques. …”
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18739
Image 2_Loss of calcium/calmodulin-dependent protein kinase kinase 2, transferrin, and transferrin receptor proteins in the temporal cortex of Alzheimer’s patients postmortem is as...
Published 2024“…</p>Results<p>CAMKK2, TF, and TFRC levels were significantly decreased in AD patients’ temporal cortices compared to CN individuals, independent of age or postmortem interval-related changes. …”
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18740
Image 1_Enhancement of host defense against Helicobacter pylori infection through modulation of the gastrointestinal microenvironment by Lactiplantibacillus plantarum Lp05.tif
Published 2025“…Lp05 treatment significantly modified the intestinal and gastric microbiota, increasing beneficial bacteria like Lactobacillus and Ligilactobacillus, and decreasing harmful bacteria such as Olsenella, linked to pathological conditions.…”