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significant changes » significant challenge (Expand Search)
significant cause » significant change (Expand Search), significant gap (Expand Search), significant increase (Expand Search)
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19041
Data Sheet 6_Regulatory mechanism of ABCB1 transcriptional repression by HDAC5 in rat hepatocytes under hypoxic environment.zip
Published 2025“…Objective<p>Previous research has demonstrated that the hypoxic environment at high altitudes significantly alters the pharmacokinetics of many drugs, reducing their efficacy and increasing adverse effects. …”
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19042
Data Sheet 7_Regulatory mechanism of ABCB1 transcriptional repression by HDAC5 in rat hepatocytes under hypoxic environment.zip
Published 2025“…Objective<p>Previous research has demonstrated that the hypoxic environment at high altitudes significantly alters the pharmacokinetics of many drugs, reducing their efficacy and increasing adverse effects. …”
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19043
GnRH antagonist impairs the process of embryo implantation by inhibiting motility of endometrial stromal cells through reducing c-kit expression
Published 2024“…</i> 56.1%, <i>p</i> < .001) in the GnRH-ant group were significantly decreased. Contrarily, the rate of early miscarriage in the GnRH-ant group (13.95% <i>vs.…”
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19044
Table 1_Akkermansia muciniphila alleviates cognitive impairment and neuroinflammation induced by blunt chest trauma.docx
Published 2025“…Background<p>Blunt chest trauma, commonly caused by traffic accidents, falls, and violent incidents, results in both direct mechanical injury to the thoracic cavity—leading to increased intrathoracic pressure and vascular rupture—and indirect effects on the central nervous system (CNS), causing extensive damage that severely impacts patient health and quality of life. …”
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19045
Data Sheet 2_Exposure to deltamethrin leads to gill liver damage, oxidative stress, inflammation, and metabolic disorders of Japanese flounder (Paralichthys olivaceus).pdf
Published 2025“…These differentially expressed genes were significantly enriched in oxidation-reduction, ferroptosis, steroid biosynthesis, and apoptosis pathways.…”
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19046
Table 1_Exposure to deltamethrin leads to gill liver damage, oxidative stress, inflammation, and metabolic disorders of Japanese flounder (Paralichthys olivaceus).xls
Published 2025“…These differentially expressed genes were significantly enriched in oxidation-reduction, ferroptosis, steroid biosynthesis, and apoptosis pathways.…”
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19047
Image 1_Exposure to deltamethrin leads to gill liver damage, oxidative stress, inflammation, and metabolic disorders of Japanese flounder (Paralichthys olivaceus).tif
Published 2025“…These differentially expressed genes were significantly enriched in oxidation-reduction, ferroptosis, steroid biosynthesis, and apoptosis pathways.…”
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19048
Supplementary file 1_Akkermansia muciniphila alleviates cognitive impairment and neuroinflammation induced by blunt chest trauma.docx
Published 2025“…Background<p>Blunt chest trauma, commonly caused by traffic accidents, falls, and violent incidents, results in both direct mechanical injury to the thoracic cavity—leading to increased intrathoracic pressure and vascular rupture—and indirect effects on the central nervous system (CNS), causing extensive damage that severely impacts patient health and quality of life. …”
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19049
Data Sheet 3_Exposure to deltamethrin leads to gill liver damage, oxidative stress, inflammation, and metabolic disorders of Japanese flounder (Paralichthys olivaceus).pdf
Published 2025“…These differentially expressed genes were significantly enriched in oxidation-reduction, ferroptosis, steroid biosynthesis, and apoptosis pathways.…”
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19050
Data Sheet 1_Exposure to deltamethrin leads to gill liver damage, oxidative stress, inflammation, and metabolic disorders of Japanese flounder (Paralichthys olivaceus).pdf
Published 2025“…These differentially expressed genes were significantly enriched in oxidation-reduction, ferroptosis, steroid biosynthesis, and apoptosis pathways.…”
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19051
Supplementary file 2_Akkermansia muciniphila alleviates cognitive impairment and neuroinflammation induced by blunt chest trauma.docx
Published 2025“…Background<p>Blunt chest trauma, commonly caused by traffic accidents, falls, and violent incidents, results in both direct mechanical injury to the thoracic cavity—leading to increased intrathoracic pressure and vascular rupture—and indirect effects on the central nervous system (CNS), causing extensive damage that severely impacts patient health and quality of life. …”
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19052
Cytochrome bd-II oxidase CyxA promotes the pathogenicity of <i>Klebsiella pneumoniae</i> by resisting oxidative stress
Published 2025“…Additionally, the expression levels of <i>cyxA</i> at 37°C and 41°C were significantly higher compared to 30°C, and the Δ<i>cyxA</i> strain exhibited significantly lower viable counts, elevated intracellular reactive oxygen species (ROS) levels, and decreased total antioxidant capacity (T-AOC) relative to WT at 37°C and 41°C. …”
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19053
Nyamsuren, I., Mitchell, E., and Tsay, J. (April 27 - May 2, 2025), <i>Learning Sign Language with Real-Time Kinematic Feedback</i> [Poster Presentation]. The Annual Meeting of the...
Published 2025“…This growing demand emphasizes the significance of sign language—not just as a communication tool, but as a key to ensuring equal participation in society.…”
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19054
Data Sheet 1_STING regulates NETs formation by activating GSDMD in influenza viral pneumonia.pdf
Published 2025“…</p>Results<p>In this study, STING (stimulator of interferon genes) was activated in the lungs of virus-infected mice, leading to cytokine production and amplification of the immune response, thereby causing rapid deterioration of symptoms. Furthermore, excessive activation of innate immune response via STING was prevented by a STING inhibitor (C-176), which significantly reduced viral lung inflammation. …”
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19055
Roxadustat alleviates cisplatin-induced acute kidney injury by regulating fatty acid oxidation and mitochondrial function
Published 2025“…Roxadustat also remarkably decreased the expression of KIM-1 and NGAL. Furthermore, roxadustat significantly abolished the expression of Bax and cleaved caspase 3, two apoptosis marker proteins. …”
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19056
The evolution of inharmonicity and noisiness in contemporary popular music
Published 2025“…From 1961 to 1972, inharmonicity in popular music, initially only slightly higher than in orchestral music, increased significantly. Between 1972 and 1986, this rise in inharmonicity was accompanied by an increase in noise, but since 1986, both inharmonicity and noise have moderately decreased. …”
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19057
Data Sheet 1_Impaired SREBP1-mediated regulation of lipid metabolism promotes inflammation in chronic endometritis.pdf
Published 2025“…Importantly, EPA-containing phospholipids were also decreased in endometrial tissue from human CE patients. …”
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19058
<b>The inhibitory and anti-inflammatory effects of TMP269 on peste des petits ruminants virus replication</b>
Published 2025“…Western blot analysis showed that TMP269 treatment significantly suppressed PPRV replication in Vero and caprine endometrial epithelial cells (EECs). …”
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19059
Table_4_Effects of clear corneal incision location and morphology on corneal surgically induced astigmatism and higher-order aberrations after ICL V4c implantation.DOCX
Published 2024“…Anterior corneal SIA was significantly correlated to Dis-En and Dis-Ex in the superior CCI group. …”
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19060
Table_5_Effects of clear corneal incision location and morphology on corneal surgically induced astigmatism and higher-order aberrations after ICL V4c implantation.DOCX
Published 2024“…Anterior corneal SIA was significantly correlated to Dis-En and Dis-Ex in the superior CCI group. …”