Data Sheet 1_Characterization of the Vibrio anguillarum VaRyhB regulon and role in pathogenesis.docx by Yingjie Li (2106778)

“…The virulence of VaRyhB was evaluated by challenging turbot larvae intraperitoneally. </p>Results<p>The small RNA called VaRyhB identified in V. anguillarum strain 775 is significantly longer than that in Escherichia coli. …”

Supplementary file 1_A natural PCID2-Targeting compound suppresses hepatocellular carcinoma progression: evidence from structure-based discovery and biological evaluation.docx by Zebanuer Yuemaierjiang (22702064)

“…Exploratory analysis related to mechanisms were performed via Western blotting.</p>Results<p>β-PGG was identified as a promising PCID2-targeting compound by molecular docking, and SPR confirmed its direct binding to PCID2. β-PGG significantly reduced HCC cell proliferation, migration, and invasion, while inducing apoptosis and cell cycle arrest. …”

Image 1_Metformin attenuates alveolar bone destruction in mice with apical periodontitis and inhibits pro-inflammatory cytokine synthesis in lipopolysaccharide-stimulated RAW264.7... by Chunmei Ren (10921089)

“…</p>Results<p>Metformin significantly reduced periapical bone destruction on postoperative days 21 and 28, and decreased the number of osteoclasts on the periapical alveolar bone on postoperative day 28. …”

Image 1_A natural PCID2-Targeting compound suppresses hepatocellular carcinoma progression: evidence from structure-based discovery and biological evaluation.png by Zebanuer Yuemaierjiang (22702064)

“…Exploratory analysis related to mechanisms were performed via Western blotting.</p>Results<p>β-PGG was identified as a promising PCID2-targeting compound by molecular docking, and SPR confirmed its direct binding to PCID2. β-PGG significantly reduced HCC cell proliferation, migration, and invasion, while inducing apoptosis and cell cycle arrest. …”

Image 3_Metformin attenuates alveolar bone destruction in mice with apical periodontitis and inhibits pro-inflammatory cytokine synthesis in lipopolysaccharide-stimulated RAW264.7... by Chunmei Ren (10921089)

“…</p>Results<p>Metformin significantly reduced periapical bone destruction on postoperative days 21 and 28, and decreased the number of osteoclasts on the periapical alveolar bone on postoperative day 28. …”

Table 1_Molecular, biofilm and motility characterization of Acinetobacter baumannii isolated from a neonatal intensive care unit at a children’s hospital in South China.xlsx by Zelin Yu (22500707)

“…Twitching motility was markedly reduced in ST1959 and also decreased after levofloxacin exposure.</p>Conclusion<p>This NICU outbreak was driven by CRAB ST195 harboring a conserved resistome. …”

Image 4_Metformin attenuates alveolar bone destruction in mice with apical periodontitis and inhibits pro-inflammatory cytokine synthesis in lipopolysaccharide-stimulated RAW264.7... by Chunmei Ren (10921089)

“…</p>Results<p>Metformin significantly reduced periapical bone destruction on postoperative days 21 and 28, and decreased the number of osteoclasts on the periapical alveolar bone on postoperative day 28. …”

Table2_Identification of telomere-related lncRNAs and immunological analysis in ovarian cancer.xlsx by Weina Xu (558990)

“…Background<p>Ovarian cancer (OC) is a global malignancy characterized by metastatic invasiveness and recurrence. …”

Table 1_Polygonatum cyrtonema Hua polysaccharides alleviate muscle atrophy and fat lipolysis by regulating the gut microenvironment in chemotherapy-induced cachexia.docx by Rongrong Zhou (3341903)

“…Additionally, the agonist of free fatty acid receptor 2 (FFAR2)—a crucial short-chain fatty acid (SCFA) signaling molecule—was used to investigate the role of gut microbiota metabolites, specifically SCFAs, in the treatment of cancer cachexia, with comparisons to PCPs.</p><p>Results: This study demonstrated that PCPs significantly mitigated body weight loss, restored muscle fiber atrophy and mitochondrial disorder, alleviated adipose tissue wasting, strengthened the intestinal barrier integrity, and decreased the intestinal inflammation in chemotherapy-induced cachexia. …”

Image 2_Metformin attenuates alveolar bone destruction in mice with apical periodontitis and inhibits pro-inflammatory cytokine synthesis in lipopolysaccharide-stimulated RAW264.7... by Chunmei Ren (10921089)

“…</p>Results<p>Metformin significantly reduced periapical bone destruction on postoperative days 21 and 28, and decreased the number of osteoclasts on the periapical alveolar bone on postoperative day 28. …”

Table1_Identification of telomere-related lncRNAs and immunological analysis in ovarian cancer.docx by Weina Xu (558990)

“…Background<p>Ovarian cancer (OC) is a global malignancy characterized by metastatic invasiveness and recurrence. …”

Data Sheet 1_Molecular insights into Atorvastatin’s role in delaying intervertebral disc degeneration.zip by Yupeng Li (507508)

“…Apoptosis within the discs was further examined by electron microscopy.</p>Results<p>Pretreatment with 10 μM atorvastatin significantly improved the survival rate of NPCs exposed to hydrogen peroxide (H₂O₂) and reduced apoptosis. …”

Data Sheet 1_The effect of establishment method and shade zones within solar arrays on pasture production in agrivoltaics production system.docx by Azad Dazaea (22173454)

“…However, herbage production did not differ significantly among establishment methods in either 2020/21 (p = 0.10) or 2021/22 (p = 0.17). …”

DataSheet1_Identification of telomere-related lncRNAs and immunological analysis in ovarian cancer.docx by Weina Xu (558990)

“…Background<p>Ovarian cancer (OC) is a global malignancy characterized by metastatic invasiveness and recurrence. …”

Data Sheet 1_Comprehensive metagenomic and lipidomic analysis showed that baicalin could improve depressive behaviour in atherosclerotic mice by inhibiting nerve cell ferroptosis.z... by Peng Ren (337555)

“…Metabolic pathway enrichment analysis showed that differential lipid PEs were significantly enriched in the iron death pathway, and our further in vitro cellular experiments showed that baicalin could inhibit Erastin-induced Ferroptosis in the hippocampal neuronal cell line HT-22 by promoting the expression of SLC7A11, GSH, and GPX4, inhibiting the expression of ACSL4, and decreasing the cellular ROS.…”

Supplementary file 1_Single-cell and bulk transcriptomic analyses reveal PANoptosis-associated immune dysregulation of fibroblasts in periodontitis.zip by Erli Wu (17785482)

“…Finally, bulk RNA-seq data were subjected to comprehensive analysis using 113 machine learning models to screen for core PANoptosis-associated genes, which were subsequently validated through qPCR and immunohistochemistry in gingival tissues.</p>Results<p>scRNA-seq analysis revealed a decreased proportion of HGFs alongside enrichment of multiple PANoptosis-related pathways in PD samples. …”

SEAwise synthesis of predicted impacts of changes in habitat and spatial management measures suggested in SEAwise for online tool by Dimitris Damalas (15976639)

“…</li></ul><p dir="ltr">The scenarios investigated in SEAwise suggest that prohibition of certain fishing practices, not only in currently designed MPAs but also in fit-to-purpose areas to limit the risk of incidental species and the degradation of benthic status, will significantly impact the overall fisheries economy and fish populations. …”

Maresin-1 alleviates sepsis-induced acute kidney injury by inhibiting ferroptosis via the Nrf2/HO-1/Gpx4 signaling pathway by Lili Tang (23345)

“…Nrf2 knockdown was used to validate its role in MaR-1-mediated effects.</p> <p>MaR-1 significantly improved cell viability and reduced ferroptosis-related markers (ROS, MDA, and iron ion concentration) <i>in vitro</i>. …”

Table 3_Integrated analysis of miRNAs-mRNAs in skeletal muscle development revealed that novel-miR-766 affects myoblast differentiation and myofiber-type formation in sheep.xlsx by Zhenzhen Gu (21488168)

“…In vitro assays revealed that myoblast differentiation and myotube formation were significantly inhibited by MYH3 knockdown via siMYH3 and that novel-miR-766 targets and decreases the expression of MYH3. …”

Table 5_Integrated analysis of miRNAs-mRNAs in skeletal muscle development revealed that novel-miR-766 affects myoblast differentiation and myofiber-type formation in sheep.xlsx by Zhenzhen Gu (21488168)

“…In vitro assays revealed that myoblast differentiation and myotube formation were significantly inhibited by MYH3 knockdown via siMYH3 and that novel-miR-766 targets and decreases the expression of MYH3. …”