Supplementary Material for: Diverse Obesity Trajectories in a Family including Identical Twins with a Pathogenic MC4R Variant حسب figshare admin karger (2628495)

"…Twin 2 had a sedentary lifestyle and epilepsy and had a peak BMI of 30.1 kg/m2; she responded well to naltrexone-bupropion and BMI decreased to 26 kg/m2. Conclusion: The manifestation of obesity, even in cases of monogenic obesity, can vary significantly due to the influence of environmental and lifestyle factors.…"

Raw data حسب Jiaxin Wang (21706805)

"…The results of this study indicate that compared to the model group, the content of regulatory enzymes and main products (mainly GCK) of the glycolytic pathway significantly decreased after administration of Rb1, and the key enzyme ACC for fatty acid synthesis also significantly decreased.…"

Image 1_Uptake of iron from ferrous fumarate can be mediated by clathrin-dependent endocytosis in Hutu-80 cells.tiff حسب Agata Tarczykowska (20620430)

"…Iron uptake (ferritin L) from ferrous fumarate (0.5 mM, 24 h) in DMT1 silenced cells was significantly decreased (60% ± 11%) in comparison to iron controls while a 1-h dose of ferrous fumarate (0.5 mM) significantly decreased ferritin L formation in the presence of the clathrin inhibitor chlorpromazine (61% ± 10%, in post-confluent cells and 37% ± 9% in non-confluent cells). …"

Data Sheet 1_Psychological Well-Being in Adults Across the COVID-19 Pandemic: A Two-Year Longitudinal Study.docx حسب Melanie Ehrler (9759152)

"…Decreasing or consistently low well-being was significantly associated with younger age, limited social support, caregiving responsibilities, concerns about COVID-19 infection, and stress due to pandemic-related changes.…"

Table 1_Uptake of iron from ferrous fumarate can be mediated by clathrin-dependent endocytosis in Hutu-80 cells.docx حسب Agata Tarczykowska (20620430)

"…Iron uptake (ferritin L) from ferrous fumarate (0.5 mM, 24 h) in DMT1 silenced cells was significantly decreased (60% ± 11%) in comparison to iron controls while a 1-h dose of ferrous fumarate (0.5 mM) significantly decreased ferritin L formation in the presence of the clathrin inhibitor chlorpromazine (61% ± 10%, in post-confluent cells and 37% ± 9% in non-confluent cells). …"

Data Sheet 1_Dendritic cells in the human vaginal mucosa can direct CD4+ T cell responses by expressing surface OX40L.pdf حسب HyeMee Joo (175770)

"…Neutralizing OX40L with anti-OX40L antibody significantly decreased the frequency of Th2-type CD4⁺ T cells with a reduction of CD4⁺ T cell proliferation, while increasing the frequency of IL - 10-producing CD4⁺ T cell responses. …"

Data Sheet 2_Dendritic cells in the human vaginal mucosa can direct CD4+ T cell responses by expressing surface OX40L.pdf حسب HyeMee Joo (175770)

"…Neutralizing OX40L with anti-OX40L antibody significantly decreased the frequency of Th2-type CD4⁺ T cells with a reduction of CD4⁺ T cell proliferation, while increasing the frequency of IL - 10-producing CD4⁺ T cell responses. …"

Supplementary file 1_The effect of probiotics on the diarrhea and constipation outcomes in children: an umbrella review of systematic reviews and meta-analyses.docx حسب Qizheng Wang (6440891)

"…Also, it is successful in reducing diarrhea duration [weighted mean difference (WMD) = −1.85; 95% CI: −2.83, −0.86] and [standardized mean difference (SMD) = −0.94; 95% CI: −1.32, −0.56] significantly. Moreover, probiotics supplementation resulted in decreased stool frequency (WMD = −0.21; 95% CI: −0.37, −0.04). …"

Table1_Adverse event profile differences between pralsetinib and selpercatinib: a real-world study based on the FDA adverse events reporting system.docx حسب Qiong Jie (13270095)

"…The risk of AEs such as decreased platelet count, anemia, decreased white blood cell count, pneumonitis, asthenia, and edema caused by pralsetinib is significantly higher than that of selpercatinib. …"

Hair-follicle-associated pluripotent (HAP) stem-cell-sheet implantation accelerates cutaneous wound closure and suppresses scar formation in a mouse model حسب Koya Obara (12009506)

"…Expression levels of TGF-β1, COL1A2 and COL3A1 mRNA in the wound were significantly decreased in HAP stem cell-implanted mice compared with non-implanted control mice. …"

Image2_Adverse event profile differences between pralsetinib and selpercatinib: a real-world study based on the FDA adverse events reporting system.TIF حسب Qiong Jie (13270095)

"…The risk of AEs such as decreased platelet count, anemia, decreased white blood cell count, pneumonitis, asthenia, and edema caused by pralsetinib is significantly higher than that of selpercatinib. …"

Table2_Adverse event profile differences between pralsetinib and selpercatinib: a real-world study based on the FDA adverse events reporting system.docx حسب Qiong Jie (13270095)

"…The risk of AEs such as decreased platelet count, anemia, decreased white blood cell count, pneumonitis, asthenia, and edema caused by pralsetinib is significantly higher than that of selpercatinib. …"

Image1_Adverse event profile differences between pralsetinib and selpercatinib: a real-world study based on the FDA adverse events reporting system.TIF حسب Qiong Jie (13270095)

"…The risk of AEs such as decreased platelet count, anemia, decreased white blood cell count, pneumonitis, asthenia, and edema caused by pralsetinib is significantly higher than that of selpercatinib. …"

RipU^K60 impacts actin cytoskeleton organization at 48 hours post infiltration. حسب Rachel Hiles (20477573)

"…(G,H) RipU^K60 significantly increased actin filament density (G), and decreased actin bundling (H) compared to controls at 48 hpi. …"

The quality metrics of 4C-seq data. حسب Tingting Jiang (169999)

"…Functional assays demonstrated that targeted repression of Pparα-En4 region significantly decreased <i><i>Ppar</i>α</i> expression and impaired brown adipocyte differentiation and thermogenesis. …"

Table 1_From feed to field: effect of dietary protein level and use of a blend of feed additives on gaseous emissions from growing-finishing pig slurry.docx حسب Esperanza Fuertes (20628794)

"…NH₃ emissions from the room and slurry pit decreased by over 38%, while CH₄ emissions, although higher in LP diets, were mitigated with the LPA diet. …"

Raw data for quantitative real-time PCR analysis. حسب Hyerim Park (303433)

"…Compared to mice on the P-MAL diet alone, Lp^WJL supplementation significantly increased muscle mass and size, resulting in enhanced muscle strength and endurance capacity. …"

Data Sheet 1_Autoimmune thyroid disease and human health: a systematic review of Mendelian randomization studies.xlsx حسب Peijin Li (220400)

"…MR analyses indicated that AITD significantly increased the risk of coronary atherosclerosis, deep venous thrombosis, chronic obstructive pulmonary disease, major depression, diabetic neuropathy, carpal tunnel syndrome, neuromyelitis optica spectrum disorder, diabetic retinopathy, childhood absence epilepsy, rheumatoid arthritis, systemic lupus erythematosus, psoriatic arthritis, inflammatory bowel disease, crohn's disease, vitiligo, myasthenia gravis, alopecia areata, type 1 and type 2 diabetes, sarcoidosis, frozen shoulder, drug eruptions, cataract, early age-related macular degeneration, pernicious anemia, Helicobacter pylori infection, temporomandibular disorders, migraine, frailty, primary biliary cholangitis, knee osteoarthritis, gout, and osteoporosis, while decreasing the risk of lung cancer, polyneuropathies, allergic rhinitis, telomere length, and serum vitamin A levels. …"

Tilmicosin inhibits the infections of currently prevalent porcine reproductive and respiratory syndrome viruses via the downregulation of CD163 expression حسب Ming Qiu (762714)

"…Flow cytometric analysis indicated that anti-inflammatory may reverse the downregulation effect of tilmicosin on CD163, while pro-inflammatory mediators can enhance the downregulation effect of tilmicosin on CD163, which leads to increased and decreased replication of PRRSV, respectively. …"

Image 2_Viral encephalitis and seizures cause rapid depletion of neuronal progenitor cells and alter neurogenesis in the adult mouse dentate gyrus.tif حسب Alberto Pauletti (10920690)

"…They resumed proliferation at 14 dpi, but, did not recover to CTR levels, and displayed aberrant migration patterns. (2) The number of proliferating NSCs significantly decreased within the dorsal DG of TMEV mice at 14 dpi compared to CTR, while (3) a heightened population of proliferating astrocytes was observed. …"