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significant mean » significant main (Expand Search), significant green (Expand Search), significant gap (Expand Search)
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21161
Nomogram model.
Published 2025“…</p><p>Conclusion</p><p>Decreased RBC/ALB and elevated NLR may be pivotal factors contributing to false-negative IGRA results in PTB patients. …”
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21162
Table 5_Integrated analysis of miRNAs-mRNAs in skeletal muscle development revealed that novel-miR-766 affects myoblast differentiation and myofiber-type formation in sheep.xlsx
Published 2025“…In vitro assays revealed that myoblast differentiation and myotube formation were significantly inhibited by MYH3 knockdown via siMYH3 and that novel-miR-766 targets and decreases the expression of MYH3. …”
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21163
Data Sheet 1_Molecular mechanisms of deer antler in promoting osteogenic differentiation of human mesenchymal stem cells via JUN modulation.zip
Published 2025“…Machine learning approaches highlighted 7 critical genes, with JUN emerging as the core gene. JUN levels were significantly decreased during osteogenic differentiation, showing high diagnostic accuracy (AUCs: 0.977-1.000). …”
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21164
Table 6_Integrated analysis of miRNAs-mRNAs in skeletal muscle development revealed that novel-miR-766 affects myoblast differentiation and myofiber-type formation in sheep.xlsx
Published 2025“…In vitro assays revealed that myoblast differentiation and myotube formation were significantly inhibited by MYH3 knockdown via siMYH3 and that novel-miR-766 targets and decreases the expression of MYH3. …”
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21165
Supplementary Material for: DOT1L regulates cellular senescence during the progression from acute kidney injury to chronic kidney disease via the micro-222-5p/WNT9B signaling pathw...
Published 2025“…In the doxorubicin -induced HK-2 cell model, DOT1L inhibition markedly decreased cellular senescence and lowered mRNA and protein levels of senescence markers, while alleviating cell cycle arrest. …”
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21166
E9.5 <i>TRAF7</i><sup><i>KO</i></sup>-asterisk vs. WT DEGs.
Published 2024“…Histological examination of anterior thalamic nuclei demonstrated decreased myelination of anteroventral nuclei but not of anterodorsal nuclei in P23 <i>Rik</i><sup><i>null</i></sup> mice. …”
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21167
Autophagy induced by mechanical stress sensitizes cells to ferroptosis by NCOA4-FTH1 axis
Published 2025“…In this study, we reveal that heightened mechanical tension sensitizes cells to ferroptosis, whereas decreased mechanics confers resistance. Mechanistically, reduced mechanical tension reduces intracellular free iron levels by enhancing FTH1 protein expression. …”
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21168
DNA damage protecting effects of EAExCC.
Published 2025“…The results demonstrated that higher doses (200 mg) of <i>C. chinense</i> methanol extract inhibited immune responses, whereas lower doses helped restore them. The extracts significantly decreased pro-inflammatory mediators and cytokines in LPS-activated macrophages. …”
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21169
Table 1_Molecular mechanisms of deer antler in promoting osteogenic differentiation of human mesenchymal stem cells via JUN modulation.docx
Published 2025“…Machine learning approaches highlighted 7 critical genes, with JUN emerging as the core gene. JUN levels were significantly decreased during osteogenic differentiation, showing high diagnostic accuracy (AUCs: 0.977-1.000). …”
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21170
Data Sheet 1_Speaker-story mapping as a method to evaluate audiovisual scene analysis in a virtual classroom scenario.pdf
Published 2025“…Performance decreased when comparing the 360° video and “binaural” audio experiment with either the experiment using “diotic” audio and 360°, or using “binaural” audio with CGI-based, showing the usefulness of the test method in investigating influences on cognitive audiovisual scene analysis performance.…”
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21171
Supplementary file 1_A natural PCID2-Targeting compound suppresses hepatocellular carcinoma progression: evidence from structure-based discovery and biological evaluation.docx
Published 2025“…Mechanistically, β-PGG decreased PCID2 expression and downregulated Cyclin D1 and CDK6. …”
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21172
XRD diffraction pattern spectra of PFAgNPs.
Published 2025“…The no observed adverse effect level was 50 mg/kgBW, the lowest observed adverse effect level was 100 mg/kgBW, and median lethal dose (LD<sub>50</sub>) was 1000 mg/kg. The PFAgNPs significantly decreased (<i>P</i> < 0.05) serum proteins, cholesterol, estrogen and progesterone alongside preservation of the histoarchitecture of the uterus. …”
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21173
Model framework.
Published 2024“…This study underscores the significance of the COVID-19 vaccine booster policy. …”
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21174
Table 1_Identification of potential miRNA biomarkers for neurobrucellosis diagnosis.xlsx
Published 2025“…Additionally, RT-qPCR results revealed decreased levels of VAV3 (vav guanine nucleotide exchange factor 3, a target of miR-499a-5p) and IGF1 (insulin like growth factor 1, a target of miR-576-5p) in the CSF samples of NB patients.…”
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21175
Flowchart of Study Design and Analysis.
Published 2025“…</p><p>Conclusion</p><p>Decreased RBC/ALB and elevated NLR may be pivotal factors contributing to false-negative IGRA results in PTB patients. …”
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21176
Table 2_Expression, prognosis and preliminary investigation of the mechanism of action of ACTR6, a member of the ARPs gene family, in hepatocellular carcinoma.xlsx
Published 2025“…</p>Results<p>We found that, in addition to ACTR3C, 17 ARPs were significantly overexpressed in HCC compared with normal tissues. …”
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21177
Table 1_Iron overload promotes myeloid differentiation of normal hematopoietic stem cells and educates macrophage mediated immunosuppression in acute myeloid leukemia.docx
Published 2025“…Functionally, iron overload decreased the phagocytic function of LAMs against leukemia cells and inhibited LAM-induced T cell activation by acquiring a tolerogenic phenotype with aberrant immune checkpoints. …”
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21178
Image 4_Iron overload promotes myeloid differentiation of normal hematopoietic stem cells and educates macrophage mediated immunosuppression in acute myeloid leukemia.png
Published 2025“…Functionally, iron overload decreased the phagocytic function of LAMs against leukemia cells and inhibited LAM-induced T cell activation by acquiring a tolerogenic phenotype with aberrant immune checkpoints. …”
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21179
Table 1_SRC is a potential target of Arctigenin in treating triple-negative breast cancer: based on machine learning algorithms, molecular modeling and in Vitro test.xlsx
Published 2025“…Western blotting indicated that AG significantly reduced the levels of Bcl-2, caspase-3, and caspase-9, as well as decreased SRC, p-PI3K-p85, p-AKT1, p-MEK1/2, and p-ERK1/2 expression in TNBC cells in a concentration dependent manner.…”
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21180
Table 3_Identification of potential miRNA biomarkers for neurobrucellosis diagnosis.xlsx
Published 2025“…Additionally, RT-qPCR results revealed decreased levels of VAV3 (vav guanine nucleotide exchange factor 3, a target of miR-499a-5p) and IGF1 (insulin like growth factor 1, a target of miR-576-5p) in the CSF samples of NB patients.…”