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significant changes » significant challenge (Expand Search)
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20721
Table1_NK cells contribute to the resolution of experimental malaria-associated acute respiratory distress syndrome after antimalarial treatment.pdf
Published 2024“…In contrast, NK cells were crucial in the initiation of resolution upon antimalarial treatment, as survival was significantly decreased in the absence of NK cells. Considerably increased IL-10 expression by NK cells suggested an anti-inflammatory and pro-resolving phenotype. …”
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20722
Data Sheet 1_Pharmacist-led surgical medicines prescription optimization and prediction service improves patient outcomes - a machine learning based study.docx
Published 2025“…In Phase 3, the acceptance rate of pharmacist recommendations rose to 71.3%, while the length of stay, total hospitalization costs, and medication costs significantly decreased (p < 0.05), indicating overall improvement compared to Phase 1.…”
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20723
A Hydrate-Bearing Sediment Gas Replacement Mechanical Behavior Regulation Mechanism and Slope Stability Analysis
Published 2025“…As saturation increases, the Γ value of the critical state line decreases, while the λ value increases. (3) For slope simulations, increased hydrate saturation significantly raises the safety factor for gentler slopes, while the reinforcing effect of gas replacement is weaker for steeper slopes with higher saturation.…”
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20724
Table 1_Prevalence and prognostic value of sarcopenia in patients with bladder cancer undergoing radical cystectomy: a systematic review and meta-analysis.docx
Published 2025“…</p>Objectives<p>This study was conducted to systematically evaluate the prognostic significance of sarcopenia in patients with bladder cancer undergoing RC.…”
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20725
Data Sheet 3_StACS3-mediated drought stress adaptation in potato involves interactions with StPP2C2 and St14-3-3 proteins.pdf
Published 2025“…In contrast, silencing StACS3 significantly reduces stress-induced ethylene accumulation and enhances drought resilience, including decreased cell death and increased antioxidant activity. …”
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20726
Table 1_Association between body composition in early pregnancy and the risk of gestational diabetes mellitus.docx
Published 2025“…RCS analysis indicated that the risk of GDM continuously increased with higher levels of PBF and FM, whereas it decreased with FFM and LM (p-overall < 0.001, p-non-linear range: 0.073–0.924). …”
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20727
Convergence trends for IEEE 33-bus test system.
Published 2025“…<div><p>Recent research has concentrated on emphasizing the significance of incorporating renewable distributed generations (RDGs), like photovoltaic (PV) and wind turbines (WTs), into the distribution system to address issues related to distributed generation (DG) allocation. …”
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20728
<b>Metabolic Improvements with Tirzepatide in Lipodystrophy: A Novel Option?</b>
Published 2025“…These disorders are defined by abnormal fat distribution, with near-total (generalized lipodystrophy, GL) or partial (partial lipodystrophy, PL; e.g. familial partial lipodystrophy, FPLD) absence of adipocyte mass leading to a decreased ability to store lipids safely. Excess lipids are more likely to be stored in non-adipose tissues, which leads to the metabolic manifestations. …”
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20729
Image 8_Slavs in the closet: computational genomic analysis reveals cryptic slavic signatures in the Avar Khaganate and their contribution to medieval Croatian population formation...
Published 2025“…This approach revealed substantial Baltic genetic components in early Slavic populations (57% in Slovakia/Slovenia) decreasing to 39%–51% in medieval Croatian samples. …”
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20730
Image 1_Pharmacological inhibition of the RhoA pathway by melatonin reduces viral replication and proinflammatory response against ZIKV and DENV-4 neuroinfections.tiff
Published 2025“…</p>Results<p>Melatonin treatment significantly reduced ZIKV and DENV-4 replication and the associated inflammatory response in U87-MG cells. …”
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20731
DataSheet1_Coptisine enhances the sensitivity of chemoresistant breast cancer cells by inhibiting the function and expression of ABC transporters.PDF
Published 2024“…In MCF-7/ADR and MDA-MB-231/ADR cells, COP (31 μM) enhanced DOX cytotoxicity with CI (0.77 and 0.75), RR (2.58 and 3.33), and IB suggesting synergism. COP significantly inhibits ABCT function in resistant BC cell lines, increases Rho123 accumulation, and decreases efflux more than VER; 2.1 and 1.2-fold, respectively. …”
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20732
The updating positions of IGWO.
Published 2025“…<div><p>Recent research has concentrated on emphasizing the significance of incorporating renewable distributed generations (RDGs), like photovoltaic (PV) and wind turbines (WTs), into the distribution system to address issues related to distributed generation (DG) allocation. …”
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20733
Table 1_Extraction of anthocyanins from purple sweet potato: evaluation of anti-inflammatory effects in a rheumatoid arthritis animal model, mechanistic studies on inflammatory cel...
Published 2025“…</p>Results<p>PSPA significantly reduced joint swelling and structural damage in CIA rats, with the highest dose (40 mg/kg) reducing tissue hyperplasia and inflammatory infiltration. …”
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20734
Table 3_Elevated miR-17-5p facilitates mycobacterial immune evasion by targeting MAP3K2 in macrophages.doc
Published 2025“…</p>Results<p>miR-17-5p expression was significantly elevated in M. avium–infected macrophages, as well as in serum and peripheral blood mononuclear cells (PBMCs) from TB patients. …”
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20735
Data Sheet 7_StACS3-mediated drought stress adaptation in potato involves interactions with StPP2C2 and St14-3-3 proteins.pdf
Published 2025“…In contrast, silencing StACS3 significantly reduces stress-induced ethylene accumulation and enhances drought resilience, including decreased cell death and increased antioxidant activity. …”
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20736
The optimized results of the Egypt MEDN 15-Bus.
Published 2025“…<div><p>Recent research has concentrated on emphasizing the significance of incorporating renewable distributed generations (RDGs), like photovoltaic (PV) and wind turbines (WTs), into the distribution system to address issues related to distributed generation (DG) allocation. …”
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20737
Image 1_Integrative bulk and single-cell transcriptome analyses reveal integrated stress response-related biomarkers in periodontitis with experimental validation.tif
Published 2025“…RT-qPCR results confirmed that the expression levels of BTG2, DERL3, FOS, and HSPA13 were significantly upregulated, while YOD1 expression was downregulated in the PD group (P < 0.05), which was consistent with the database-predicted patterns.…”
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20738
Utilization of lactate trajectory models for predicting acute kidney injury and mortality in patients with hyperlactatemia: insights across three independent cohorts
Published 2025“…When compared with the Traj-3, Traj-2 was only significantly associated with the decreased risk of hospital mortality (OR 0.17, 95% CI 0.14–0.20, <i>p</i> < 0.001), but no with the likelihood of AKI development (OR 0.90, 95% CI 0.77–1.05, <i>p</i> = 0.172). …”
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20739
Table 1_Communal and agentic teacher behavior in teacher-child dyads. A new self-report scale based on a circumplex approach.docx
Published 2024“…Teacher interpersonal behavior correlated significantly with perceived relationship quality and emotions: high relationship quality and positive emotions were associated with high communion and low agency, whereas low relationship quality and negative emotions were associated with low communion and high agency, supporting construct validity. …”
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20740
Image4_Neuroprotective effects of a novel peptide through the Rho-integrin-Tie2 and PI3K/Akt pathways in experimental autoimmune encephalomyelitis model.JPEG
Published 2025“…</p>Results<p>The results showed that C16 significantly improved the clinical score and cortical somatosensory/motor evoked potential. …”