S1 Data - حسب Richard Junior Zapata Dongo (17912565)

الموضوعات:

Combination therapy exhibited apoptosis in Ba/F3 EML4-ALKmutant cell models. حسب Richard Junior Zapata Dongo (17912565)

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Ba/F3 EML4-ALK^mutants exhibit variable dose-response to ABT-199 treatment. حسب Richard Junior Zapata Dongo (17912565)

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Molecular docking showed that ABT-199 can fit into active site of ALK^Mutant. حسب Richard Junior Zapata Dongo (17912565)

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The binding energy values of ATP, ALK inhibitors and ABT-199 to ALK were obtained from AlphaFold and modeled protein structures. حسب Richard Junior Zapata Dongo (17912565)

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Amino acids interactions and binding energy describe that ABT-199 binds to ALK^Mutant. حسب Richard Junior Zapata Dongo (17912565)

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Western blot analysis of drug combinations. حسب Richard Junior Zapata Dongo (17912565)

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ALKL1196M –ABT199 interactions. حسب Richard Junior Zapata Dongo (17912565)

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ALK^wt–ABT199 interactions. حسب Richard Junior Zapata Dongo (17912565)

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BCL2 protein keeps their expression in different conditions treatment nevertheless each EML4-ALK cell modells exhibit variable expression. حسب Richard Junior Zapata Dongo (17912565)

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ALK inhibitors (Positive control) and ABT199 (Proposed binding) in complex with the ALK active side. حسب Richard Junior Zapata Dongo (17912565)

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BCL2 antiapoptotic protein exhibits heterogeneous expression in Ba/F3 EML4-ALK^mutants. حسب Richard Junior Zapata Dongo (17912565)

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Negative (Prednisone) and basal (ATP) control compounds binding to ALK protein. حسب Richard Junior Zapata Dongo (17912565)

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Relative abundance of the phyla of dominant bacteria based on 16S rRNA gene amplicon sequencing. حسب Melissa S. Shinfuku (19942206)

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Multivariable multilevel mixed-effects logistic regression analyses of zinc utilisation and predictors among under-five children with diarrhoea, Ethiopia, 2005–2016 (N = 29,525). حسب Girma Beressa (9580436)

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Protein-protein interaction network and hub genes. حسب Wei He (131453)

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Differentially expressed genes following Mod knockdown. حسب Amalia S. Parra (4173004)

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Twenty differentially expressed senescence-related genes. حسب Wei He (131453)

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Gene set enrichment analysis (GSEA) of the DEGs. حسب Wei He (131453)

الموضوعات:

No significant differences in the numbers of eggs between Mst1^+/+ and Mst1^ΔM/ΔM mice. حسب Jianyang Li (461703)