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significant genes » significant gender (Expand Search), significant benefits (Expand Search), significant changes (Expand Search)
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19481
Table 3_Epidemiology of neonatal disorders attributable to low birthweight-global burden of disease research, 1990–2021.xlsx
Published 2025“…</p>Conclusion<p>Over the past 32 years, the global burden of neonatal diseases attributable to LBW has significantly decreased, but inequality in disease burden has intensified. …”
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19482
Mapping global urban inequality under climate change and its interaction with sustainable development
Published 2025“…<p>Global cities are significantly affected by climate change, leading to increased inequality and further vulnerability among marginalized groups. …”
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19483
Image 1_The role of E2F1 in promoting EIF4EBP1 transcription in cryptorchid mice: association with autophagy in germ cells.tif
Published 2025“…E2F1 was identified as an upstream regulator of EIF4EBP1, with knockdown of E2F1 significantly decreasing EIF4EBP1 promoter activity and binding. …”
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19484
<b>Differences in White Matter Microstructure in Children With Type 1 Diabetes Persist During Longitudinal Follow up: Relation to Dysglycemia</b>
Published 2025“…</p><p dir="ltr">We observed in 182 children (121 type 1 diabetes, vs. 61 controls) who had testing at Time 4 that FA increased, and RD, AD, MD decreased significantly in both groups, with no differences between groups for FA, RD and MD over time. …”
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19485
Table 1_Gypenoside XLIX inhibiting PI3K/AKT/FOXO1 signaling pathway mediated neuronal mitochondrial autophagy to improve patients with ischemic stroke.docx
Published 2025“…</p>Results<p>Gypenoside XLIX significantly improved neuronal viability (p < 0.01), reduced apoptosis (p < 0.01), and decreased ROS levels (p < 0.001) in OGD cells. …”
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19486
Table 1_Anemoside B4 targets RAGE to attenuate ferroptosis in sepsis-induced acute lung injury.xlsx
Published 2025“…</p>Results<p>AB4 ameliorated CLP-induced lung injury in mice, as evidenced by reduced pathological damage, lower injury scores, and a decreased lung wet-to-dry weight ratio. In vivo, AB4 significantly reduced levels of pro-inflammatory cytokines (IL-1β, TNF-α, and IL-6), decreased oxidative stress markers MDA and DHE, and increased GSH levels. …”
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19487
Table 2_Anemoside B4 targets RAGE to attenuate ferroptosis in sepsis-induced acute lung injury.xlsx
Published 2025“…</p>Results<p>AB4 ameliorated CLP-induced lung injury in mice, as evidenced by reduced pathological damage, lower injury scores, and a decreased lung wet-to-dry weight ratio. In vivo, AB4 significantly reduced levels of pro-inflammatory cytokines (IL-1β, TNF-α, and IL-6), decreased oxidative stress markers MDA and DHE, and increased GSH levels. …”
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19488
Data Sheet 1_Global, regional, and national trends and burden of multiple sclerosis in adolescents and young adults: a data analysis from 1990 to 2021 and projections to 2040.zip
Published 2025“…Background and Objectives<p>Multiple sclerosis (MS) significantly impacts adolescents and young adults (aged 15–39 years), causing substantial neurological disability. …”
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19489
Table 2_MIND diet score and its association with metabolic dysfunction-associated steatotic liver disease and gut microbiota profiles: a cross-sectional study.docx
Published 2025“…Inflammatory markers (CRP, LPS) decreased with higher adherence (all p < 0.001). Each 1-unit increase in MIND diet score was significantly associated with reductions in fasting insulin (β = −0.20 μU/mL; p < 0.001), HOMA-IR (β = −2.11; p < 0.001), CRP (β = −2.12; p < 0.001), LPS (β = −8.52; p < 0.001). …”
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19490
Data Sheet 2_Global, regional, and national trends and burden of multiple sclerosis in adolescents and young adults: a data analysis from 1990 to 2021 and projections to 2040.docx
Published 2025“…Background and Objectives<p>Multiple sclerosis (MS) significantly impacts adolescents and young adults (aged 15–39 years), causing substantial neurological disability. …”
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19491
Table1_Biomechanical effects of different mandibular movements and torque compensations during mandibular advancement with clear aligners: a finite element analysis.DOCX
Published 2024“…</p>Results<p>When the mandibular advancement was equal to or slightly excessed the occlusal opening distance, stress on the posterior PDL decreased and became more evenly distributed. Increasing the occlusal opening distance significantly raised stress on the posterior PDL and caused grater labial inclination of the mandibular anterior teeth. …”
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19492
Table 3_Anemoside B4 targets RAGE to attenuate ferroptosis in sepsis-induced acute lung injury.docx
Published 2025“…</p>Results<p>AB4 ameliorated CLP-induced lung injury in mice, as evidenced by reduced pathological damage, lower injury scores, and a decreased lung wet-to-dry weight ratio. In vivo, AB4 significantly reduced levels of pro-inflammatory cytokines (IL-1β, TNF-α, and IL-6), decreased oxidative stress markers MDA and DHE, and increased GSH levels. …”
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19493
Age-related driver injury occurrence from crashes at curve–grade combined segments
Published 2024“…</p> <p>The results emphasize the significance of tailored education and outreach countermeasures, particularly for teen and older drivers, aimed at decreasing the likelihood of injuries in such driving environments. …”
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19494
Supplementary Material for: Camrelizumab combined with Lenvatinib and RALOX-HAIC for unresectable hepatocellular carcinoma (Cal Era): a prospective, single-arm, phase II trial
Published 2025“…Grade 3-4 treatment-related adverse events occurred in 79.5% of the subjects, with the most common being decreased neutrophil count (41%), decreased platelet count (30.8%), and increased aspartate aminotransferase (23.1%). …”
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19495
Table 1_Epidemiology of neonatal disorders attributable to low birthweight-global burden of disease research, 1990–2021.xlsx
Published 2025“…</p>Conclusion<p>Over the past 32 years, the global burden of neonatal diseases attributable to LBW has significantly decreased, but inequality in disease burden has intensified. …”
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19496
Data Sheet 1_Physical activity of moderate-intensity optimizes myocardial citrate cycle in a murine model of heart failure.pdf
Published 2025“…Interestingly, 8-sWR significantly decreased myocardial citrate content in the presence of unchanged myocardial [BCAAs], ETC proteins content and mtDNA copy number.…”
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19497
DataSheet1_Protective effect of baicalin on oxidative stress injury in retinal ganglion cells through the JAK/STAT signaling pathway in vitro and in vivo.PDF
Published 2024“…</p>Results<p>In vitro experiments demonstrated that the survival rate of R28 cells after glutamate treatment dropped to 33.4%, while 10 μM baicalin significantly inhibited glutamate-induced damage in RGCs (P < 0.001) and enhanced cell viability through decreasing ROS levels, increasing antioxidant enzyme activity, and suppressing the expression of inflammatory factors iNOS, TNF-α, IL-6, and IL-1β (P < 0.001). …”
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19498
Table 2_Epidemiology of neonatal disorders attributable to low birthweight-global burden of disease research, 1990–2021.xlsx
Published 2025“…</p>Conclusion<p>Over the past 32 years, the global burden of neonatal diseases attributable to LBW has significantly decreased, but inequality in disease burden has intensified. …”
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19499
Long-Term Effects of Adalimumab in Juvenile Idiopathic Arthritis-Associated Uveitis: 3- and 6-Year Results of the ADJUVITE Trial
Published 2025“…The mean dose of methotrexate decreased significantly from 11.3 ± 4.4 mg/week at the end of the trial to 5.2 ± 6.2 mg/week at the last follow-up (<i>p</i> = 0.002). …”
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19500
Data Sheet 1_Polydatin combined with hawthorn flavonoids alleviate high fat diet induced atherosclerosis by remodeling the gut microbiota and glycolipid metabolism.pdf
Published 2025“…</p>Results<p>Polydatin combined with hawthorn flavonoids administration significantly reduced lipid and inflammatory cytokine levels, meanwhile, the atherosclerotic lesions in a high-fat diet-induced ApoE<sup>−/−</sup> mice were significantly decreased. …”