Showing 2,441 - 2,460 results of 21,342 for search '(( ((significant rates) OR (significant role)) decrease ) OR ( significant decrease decrease ))', query time: 0.83s Refine Results
  1. 2441
  2. 2442
  3. 2443
  4. 2444
  5. 2445
  6. 2446
  7. 2447
  8. 2448
  9. 2449
  10. 2450
  11. 2451
  12. 2452
  13. 2453
  14. 2454
  15. 2455
  16. 2456
  17. 2457
  18. 2458
  19. 2459
  20. 2460

    A Novel Type of PSMA-Targeting Ligands via β‑Branched Aromatic α‑Amino Acid Modification, Bearing Enhanced Tumor Targeting and Reduced Renal Toxicity by Zong-Xiao Liu (22177765)

    Published 2025
    “…<i>In vivo</i> PET/CT imaging and biodistribution analysis revealed that β-branched aromatic α-amino acids modified PSMA radioligands could maintain or even improve tumor targeting while exhibiting a more rapid renal clearance rate than [<sup>68</sup>Ga]Ga-<b>PSMA-617</b>. With average renal uptake of less than 10%ID/g, as opposed to 25%ID/g for [<sup>68</sup>Ga]Ga-<b>PSMA-617</b>, this substantial decrease in renal accumulation translates to a significantly improved safety profile by minimizing nephrotoxic risks. …”