Data Sheet 1_Brain-derived uroguanylin as a regulator of postprandial brown adipose tissue activation: a potential therapeutic approach for metabolic disorders.docx by Nikola Habek (21178259)

“…In this study, we aim to determine the expression of uroguanylin (UGN) in the mouse and human brain, its regulatory mechanisms, and its significance to patients with obesity and type 2 diabetes (T2D).…”

Table1_Variation of leaf shape with tree size: a case study using Camptotheca acuminata Decne.xlsx by Ke He (331344)

“…However, DBH did not significantly affect the ratio W/L nor the leaf roundness index. …”

Data Sheet 1_Phyllosphere microbiome responses to nano-berberine and chemical fungicides in powdery mildew infected strawberry.pdf by Meng Yang (162251)

“…The results showed that nano-fungicide application significantly reduced the disease index of powdery mildew and markedly decreased its incidence in field-grown strawberries, ultimately lowering leaf disease incidence to 5.06% with a control efficacy of 96.81%. …”

Effect of HPC silencing on phase-locking of PFC neurons to local theta. by Susanne S. Babl (21169261)

“…Percentage of neurons significantly phase-locked to PFC theta oscillations (4–12 Hz) in the sample <b>(A)</b> and choice phase <b>(B)</b> during light-off and light-on trials. …”

pH sensitive lipid polymeric hybrid nanoparticle (LPHNP) of paclitaxel and curcumin for targeted delivery in breast cancer by Hrishikesh Sarma (14827761)

“…MTT-assay studies revealed enhanced cytotoxicity of CUR and PTX as LPHNPs showing IC₅₀ value of free CUR & PTX 480.06 µg/mL decreasing to 282.97 µg/mL for CS-CUR-PTX-LPHNPs. <i>In vivo</i> pharmacokinetic evaluations in rats confirmed significantly improved bioavailability, with a 3.8-fold increase in AUC for CUR and a 6.6-fold increase for PTX. …”

Spectral shift of fluorophore NHS-esters. by Hyunwoo Kim (690467)

“…After 5 min of illumination with a 561-nm excitation laser, the fluorescence signal in the 647-nm detection channel decreased, while the signal in the 561-nm detection channel significantly increased, indicating a spectral blue-shift of the emission spectrum. …”

Movie 2 Rik^null vs. WT. by Erdyni N. Tsitsikov (20384719)

“…Histological examination of anterior thalamic nuclei demonstrated decreased myelination of anteroventral nuclei but not of anterodorsal nuclei in P23 <i>Rik</i>^<i>null</i> mice. …”

Supplementary file 2_Effects of Lactiplantibacillus plantarum DSM 33464 in children with elevated blood lead levels: a randomized, double-blind, placebo-controlled study.docx by Wenjing Ji (720509)

“…Introduction<p>Approximately one-third of the world’s children have elevated blood lead levels (BLLs), which may lead to often-irreversible decreased intelligence, behavioral difficulties, and learning problems. …”

Data Sheet 1_A novel bioactive peptide-peptoid hybrid of alpha-calcitonin gene-related peptide protects against pressure-overload induced heart failure.docx by Ambrish Kumar (558337)

“…NMEG-CGRP administration significantly attenuated these TAC-induced adverse cardiac effects in the HF mice.…”

Data Sheet 1_Fast perceptual learning induces location-specific facilitation and suppression at early stages of visual cortical processing.docx by Yajie Wang (184298)

“…<p>Tens of minutes of training can significantly improve visual discriminability of human adults, and this fast perceptual learning (PL) effect is usually specific to the trained location, with little transfer to untrained locations. …”

<b>Liraglutide treatment reverses unconventional cellular defects in induced pluripotent stem cell-derived β cells harboring a partially functional </b><b><i>WFS1</i></b><b> varian... by Silvia Torchio (611349)

“…Pancreatic β cells obtained from patient-derived induced Pluripotent Stem Cells (iPSCs) carrying this <i>WFS1 </i>variant exhibited reduced insulin processing and impaired secretory granule maturation, as evidenced by proinsulin accumulation and decreased prohormone convertase PC1/3. Moreover, they exhibited dysregulated Ca²⁺ fluxes due to altered transcription of Ca²⁺-related genes, including <i>CACNA1D</i>, and significantly reduced <i>SNAP25</i> levels, leading to uncoordinated oscillations and poor glucose responsiveness. …”

Data Sheet 1_Preoperative remote consultation for a green bariatric surgery: can telemedicine be safe for patients and sustainable for the environment?.pdf by Luigi Eduardo Conte (21669149)

“…At one-year follow-up, the mean BMI decreased to 29 kg/m² (±3). In the revisional surgery group, percent excess weight loss reached 75.4% at one year.…”

Data Sheet 1_Silica nanoparticles alleviate cadmium toxicity to Pisum sativum L. seedling growth by remodeling carbon-nitrogen metabolism.docx by Xiaohuan Yang (3697462)

“…<p>The increasing incidence of soil cadmium (Cd) pollution significantly hinders the sustainable development of agriculture and food security. …”

Data Sheet 1_Repeated biocide treatments cause changes to the microbiome of a food industry floor drain biofilm model.zip by Martin Laage Kragh (8341305)

“…Analysis of the viable survivors using MALDI-TOF MS and the regrowing biofilms using 16S rRNA amplicon sequencing showed how the diversity of the biofilm decreased but without any change in biocide tolerance as seen in log reductions (CFU/cm²). …”

Table 1_Relationships between rumen methanogens and fungal communities and their response to changes in alfalfa forms and starch in sheep diets.docx by Wenliang Guo (14825407)

“…The relative abundance of Aspergillus in the AHLR diet was significantly higher than in the AS diets (P < 0.01), and the relative abundance of Occultifur and Meyerozyma were decreased in the AH diets than in the AS diets (P < 0.05). …”

Data Sheet 1_Efficacy and safety of anlotinib combined with 125I seed implantation for iodine-refractory thyroid cancer.docx by Zhijun Chen (254277)

“…Tumor volumes in all groups decreased after treatment, with the greatest reduction within 6 months in the combination group (p < 0.001). …”

<b>Enhanced Regulation of Carbon Emissions and DOM Transport by Cascade Reservoirs in the Upper Yellow River</b> by Li Chunhui (19796262)

“…Overall, the diffusion flux of CO2(FCO2) and CH4(FCH4) at the water–air interface in each reservoir area exceeded those in natural channels. FCO2 showed a decreasing trend along the flow direction, whereas FCH4 exhibited the opposite pattern. …”

High-throughput single-cell analysis reveals Omp38-specific monoclonal antibodies that protect against <i>Acinetobacter baumannii</i> infection by Yiwei Zhang (1448599)

“…Flow cytometry and ELISA confirmed that immune cell infiltration and cytokine production, respectively, decreased in a mouse model of sublethal <i>A. baumannii</i> infection. …”

Drug-Free Mesoporous Silica Nanoparticles Enable Suppression of Cancer Metastasis and Confer Survival Advantages to Mice with Tumor Xenografts by Yu-Tse Lee (19944891)

“…In vivo studies showed that overall tumor metastasis decreased in 4T1 xenografts mice treated with MSN-PEG/TA 25 with a notable reduction in lung tumor metastasis. …”

Supplementary file 1_ZnO nanoparticles induce acute arrhythmia and heart failure in mice by disturbing cardiac ion channels.pdf by Xuexue Liu (3271641)

“…Mechanistically, exposure to ZnO NPs did not significantly affect the IK1, but it markedly decreased I_Na and I_Ca−L currents, resulting in a reduced amplitude and shortened duration of the action potential in cardiomyocytes. …”