يعرض 20,221 - 20,240 نتائج من 21,342 نتيجة بحث عن '(( ((significant source) OR (significant burden)) decrease ) OR ( significant decrease decrease ))', وقت الاستعلام: 0.60s تنقيح النتائج
  1. 20221

    Index system for well-being level. حسب Yumeng Zhang (3115050)

    منشور في 2024
    "…The results of this study suggest that the level of well-being as a whole, as well as in the eastern, central and western regions increased significantly over the period, with an “east-to-west decreasing” distribution in China. …"
  2. 20222

    Image 1_Gallic acid attenuates diabetic cardiomyopathy by inhibiting ferroptosis and protecting mitochondria via the TSPO/FTMT pathway.tif حسب Chenchao Zou (22768010)

    منشور في 2025
    "…Purpose<p>Diabetic cardiomyopathy (DCM), which is diabetes mellitus-induced cardiomyopathy, significantly elevates the risk of heart failure and sudden cardiac death. …"
  3. 20223

    Supplementary file 1_Scorpion-Centipede extracts mitigate ovariectomy-induced osteoporosis in mice through facilitating Cx3cr1 expression.docx حسب Jinghuai Ni (21023477)

    منشور في 2025
    "…In addition, SC treatment markedly increased Runx2, Osx, Alp, and Cx3cr1 while decreasing adipogenic genes like PPARγ and C/EBPα in the bone tissue of OVX mice and BMMSCs. …"
  4. 20224

    Image 5_Integrative multiomics analysis reveals association of gut microbiota and its metabolites with susceptibility to keloids.jpeg حسب Dang Li (16400478)

    منشور في 2024
    "…<p>Keloid scarring is a fibroproliferative disease of the skin, which can significantly impact one’s quality of life through cosmetic concerns, physical discomfort (itchy; painful), restricted movement, and psychological distress. …"
  5. 20225

    Image_1_Loss of Cdc42 causes abnormal optic cup morphogenesis and microphthalmia in mouse.jpg حسب Katrina S. Hofstetter (17545425)

    منشور في 2024
    "…EdU incorporation is significantly downregulated. In addition, mitotic retinal progenitor cells mislocalize deeper, basal regions, likely contributing to decreased proliferation. …"
  6. 20226

    Image 3_Unraveling impact and potential mechanisms of baseline pain on efficacy of immunotherapy in lung cancer patients: a retrospective and bioinformatic analysis.jpg حسب Zexin Zhang (7507979)

    منشور في 2024
    "…ELISA assay results indicated that the level of CXCL12 significantly decreased compared to baseline after pain was relieved.…"
  7. 20227

    Supplementary Material for: Gut microbiome composition and one-year survival outcomes among patients with reduced ejection fraction heart failure حسب figshare admin karger (2628495)

    منشور في 2025
    "…Results: HFrEF patients showed a significantly lower abundance of all bacterial taxa, except for A. muciniphila. …"
  8. 20228

    DataSheet1_Lipocalin-2 drives neuropsychiatric and cutaneous disease in MRL/lpr mice.docx حسب Sayra J. Garcia (19748644)

    منشور في 2024
    "…</p>Results<p>In this study, we found that LCN2 deficiency significantly attenuates neuropsychiatric and cutaneous disease in MRL/lpr lupus prone mice, likely by decreasing local infiltration of immune cells into the brain and skin and reducing astrocyte activation in the hippocampus. …"
  9. 20229

    Tanshinone I as a novel therapeutic agent targeting von Willebrand factor-binding protein to mitigate <i>Staphylococcus aureus</i> pathogenicity حسب Shiyu Zhou (457967)

    منشور في 2024
    "…Our findings revealed that tanshinone I significantly inhibited vWbp-induced coagulation without affecting the proliferation of <i>S. aureus</i>. …"
  10. 20230

    Table 1_Behavioral alterations in antibiotic-treated mice associated with gut microbiota dysbiosis: insights from 16S rRNA and metabolomics.xlsx حسب Asma Bibi (12057986)

    منشور في 2025
    "…The KEGG enrichment analysis of serum and brain samples showed that amino acid metabolism pathways, such as tryptophan metabolism, threonine metabolism, serotonergic synapsis, methionine metabolism, and neuroactive ligand-receptor interaction, were significantly decreased in antibiotic-treated mice. Our study demonstrates that long-term antibiotic use induces gut dysbiosis and alters metabolic responses, leading to the dysregulation of brain signaling molecules and anxiety-like behavior. …"
  11. 20231

    Table 1_Microwave ablation triggers OX40L-mediated disruption of TNFRSF4+ Treg immunosuppressive activity.docx حسب Runqi Guo (22481293)

    منشور في 2025
    "…In vivo, MWA reshaped the tumor microenvironment by significantly increasing the intratumoral CD8+/Treg ratio (P<0.001), indicating a shift toward an anti-tumor inflammatory state. …"
  12. 20232

    Molecular basis for phenotype observed in <i>Cgulp2</i>Δ and STUbLs in <i>C</i>. <i>glabrata</i>. حسب Dipika Gupta (204889)

    منشور في 2024
    "…Based on the experimental validation of quantitative mass spectrometry data, ubiquitin-proteosome pathway, purine nucleotide biosynthesis pathway, and mitochondrial function were found to be significantly impacted in <i>Cgulp2ΔCgslx8Δ</i> double mutant. …"
  13. 20233

    Charged atomization characteristics and influencing factors analysis of aviation kerosene/ethanol blended fuel حسب Xiang Shao (1355631)

    منشور في 2024
    "…As the ethanol blending ratio increases, the critical voltage required for the transition to atomization mode decreases, while the atomization cone angle gradually increases. …"
  14. 20234

    Supplementary file 1_Oxymatrine for inflammatory bowel disease in preclinical studies: a systematic review and meta-analysis.docx حسب Xuan Zhao (356028)

    منشور في 2025
    "…The data analysis results indicated that the disease activity index (DAI), histopathological score (HS), interleukin-6 (IL-6), interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), nuclear factor-κB (NF-κB), and myeloperoxidase (MPO) activity in the IBD animal models significantly decreased following intervention with oxymatrine. …"
  15. 20235

    Table 1_Integrating single-cell RNA-seq, bulk RNA-seq and network pharmacology reveals protective effect of salidroside in peritoneal dialysis-associated peritoneal fibrosis.docx حسب Shuting Li (6552)

    منشور في 2025
    "…In a murine model of peritoneal fibrosis induced by intraperitoneal injection of 4.25% PD fluid, SAL treatment significantly mitigated peritoneal fibrosis, as evidenced by reduced collagen deposition, decreased protein expression of α-smooth muscle actin and Collagen I, and a thinner peritoneum. …"
  16. 20236

    Data Sheet 5_The power of GM-CSF: immune regulation in the defense against Phialophora verrucosa infection.pdf حسب Qi Dong (119569)

    منشور في 2025
    "…</p>Results<p>Compared to WT mice, GM-CSF deficiency significantly delayed fungal clearance and prolonged disease progression, accompanied by reduced inflammatory responses and decreased neutrophil infiltration. …"
  17. 20237

    Data Sheet 3_Exposure to deltamethrin leads to gill liver damage, oxidative stress, inflammation, and metabolic disorders of Japanese flounder (Paralichthys olivaceus).pdf حسب Bingbu Li (21097373)

    منشور في 2025
    "…These differentially expressed genes were significantly enriched in oxidation-reduction, ferroptosis, steroid biosynthesis, and apoptosis pathways.…"
  18. 20238

    Form for machine recognition. حسب Zhe Hu (787283)

    منشور في 2025
    "…Following model updates with measured data, the accumulated prediction error rapidly decreases. The proposed prediction method for shape errors during pushing exhibits high accuracy and versatility in similar projects, significantly reducing time spent on manual error handling and minimizing computational inaccuracies.…"
  19. 20239

    Wheat germ agglutinin-nanoparticles encapsulating itacitinib target and suppress pro-inflammatory slan+ monocytes حسب Karen Alvarez (17620292)

    منشور في 2025
    "…ITA-loaded nanoparticles decreased HLA-DR, CD69, and CD86 expression, STAT1 phosphorylation, and cytokine production in IFN-γ-stimulated slan+ monocytes. …"
  20. 20240

    Image 1_Chito-oligosaccharide composites enhanced the adaptability of cotton seedlings to salinized soil by modulating photosynthetic efficiency and metabolite.tif حسب Mengjie An (9501175)

    منشور في 2025
    "…The results showed that salt stress reduced the contents of K<sup>+</sup> and Ca<sup>2+</sup> and enhanced the content of Na<sup>+</sup> in cotton leaves compared to the control, which inhibited leaf photosynthesis and seedling growth. COS-PA application decreased leaf Na<sup>+</sup> content significantly in salt-stressed cotton seedlings by 69.70%, and increased the leaf Ca<sup>2+</sup> content, fresh weight of each plant part, transpiration rate, leaf chlorophyll concentration (Chl a), actual quantum yield, as well as stomatal conductance by 7.22%, 46.33%-96.36%, 96.65%, 44.53%, 27.15%, and 168.24%, respectively, compared with the no COS-PA application treatment. …"