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large decrease » marked decrease (Expand Search), large degree (Expand Search)
b large » _ large (Expand Search), _ larger (Expand Search)
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increases » increased (Expand Search), increase (Expand Search)
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Kit-mediated autophagy suppression driven by a viral oncoprotein emerges as a crucial survival mechanism in Merkel cell carcinoma
Published 2025“…</p> <p><b>Abbreviation</b>: 3-MA, 3-methyladenine; AL, autolysosome; AP, autophagosome; Baf-A1, bafilomycin A<sub>1</sub>; BARA, β-α repeated autophagy specific domain; BH3, BCL2 homology 3 domain; CCD, coiled-coil domain; CHX, cycloheximide; Co-IP, co-immunoprecipitation; CQ, chloroquine; CTR, control; DAPI, 4′,6-diamidino-2-phenylindole; EBSS, Earle’s balanced salt solution; ECD, evolutionarily conserved domain; EEE, three-tyrosine phosphomimetic mutations Y229E Y233E Y352E; ER, endoplasmic reticulum; FFF, three-tyrosine non-phosphomimetic mutations; FFPE, formalin-fixed paraffin-embedded; FL, full-length; GIST, gastrointestinal stromal tumor; IB, immunoblotting; IHC, immunohistochemistry; KIT-HEK293, KIT stably expressing HEK293 cells; KRT20/CK20, keratin 20; LT, large T-antigen; LT339, MCPyV truncated LT antigen; LTco, codon-optimized MCPyV LT antigen; MCC, Merkel cell carcinoma; MCPyV<sup>−</sup>, MCPyV-negative; MCPyV, Merkel cell polyomavirus; MCPyV<sup>+</sup>, MCPyV-positive; PARP1, poly(ADP-ribose) polymerase 1; PCI, pan-caspase inhibitor; PI, propidium iodide; PtdIns3K, class III phosphatidylinositol 3-kinase; PtdIns3P, phosphatidylinositol-3-phosphate; RB1, RB transcriptional corepressor 1; RTKs, receptor tyrosine kinases; KITLG/SCF, KIT ligand; sT, small T-antigen; sTco, codon-optimized MCPyV sT antigen; T-B, Tat-BECN1; T-S, Tat-scrambled; TEM, transmission electron microscopy.…”
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Ribosomal subunit pathways are decreased in <i>Resf1</i> knockdown cells.
Published 2024“…<p>(A) GO Pathway analysis snapshots of various ribosomal subunit pathways that are decreased in 6DT1 <i>Resf1</i> KD cells. (B) The GO Cytosolic Ribosome pathway had many (C) small and large ribosomal proteins decreased in <i>Resf1</i> KD cells. …”
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DataSheet_1_Coastal vegetation responses to large dam removal on the Elwha River.pdf
Published 2023“…Introduction<p>Large dam removals provide a restoration opportunity for shrinking coastal wetland habitats. …”
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Data Sheet 1_Patient engagement in radiation oncology: a large retrospective study of survey response dynamics.docx
Published 2025“…MVA showed that higher socioeconomic disadvantage significantly decreased survey participation (ADI third tertile vs. first tertile OR=0.708, p<0.001), with each unit increase in ADI reducing the odds of completion by 1% (p<0.001). …”
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The number of expected vaccinations decreases with the expected vaccination time, whereas the peak of infections increases.
Published 2023“…Brighter colours indicate higher 〈<i>s</i>(<i>t</i><sub><i>v</i></sub>)〉. Note the nonlinear increase of <i>n</i> on the y-axis. C) Relatedly, we show the peak of infections max<sub><i>t</i></sub>(<i>i</i>(<i>t</i>)) as a heat map as function of the expected vaccination time 〈<i>t</i><sub><i>v</i></sub>〉 for the same range of vaccine arrival distributions <i>p</i><sub><i>n</i></sub> as in B). …”
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Supplementary Material for: Dysregulated MDR1 by PRDM1/Blimp1 Is Involved in the Doxorubicin Resistance of Non-Germinal Center B-Cell-Like Diffuse Large B-Cell Lymphoma
Published 2021“…In OCI-Ly3/DOX cells, NF-κB activity and PRDM1 expression decreased with an increase in drug-resistant index, whereas <i>MDR1</i> expression increased with enhanced drug resistance. …”
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DataSheet_1_Identification and Assessment of Necroptosis-Related Genes in Clinical Prognosis and Immune Cells in Diffuse Large B-Cell Lymphoma.xlsx
Published 2022“…The area under the curve (AUC) of the nomogram, risk score, and International Prognostic Index was 0.723, 0.712, and 0.537, respectively. γ/δ T cells and Macrophage 1 cells decreased while Macrophage 2 cells and Natural Killer resting cells increased in the high-risk group. …”
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DataSheet_1_Exploring the molecular mechanisms and shared gene signatures between rheumatoid arthritis and diffuse large B cell lymphoma.xlsx
Published 2022“…Next, we found that the expression level of LGALS2 gradually decreased with tumor progression in DLBCL and that increased expression of LGALS2 predicted a better prognosis for DLBCL patients. ssGSEA revealed that LGALS2 is involved in immune-related pathways and has a significant regulatory effect on human immune responses. …”
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Table1_Multi-Scale Modeling Recapitulates the Effect of Genetic Alterations Associated With Diffuse Large B-Cell Lymphoma in the Germinal Center Dynamics.docx
Published 2022“…Several transcription factors and signaling pathways that play a central role in the progression of the GC reaction and B-cell differentiation have been shown to play an oncogenic role in diffuse large B-cell lymphoma. …”
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Image_9_Comprehensive Characterization of Cachexia-Inducing Factors in Diffuse Large B-Cell Lymphoma Reveals a Molecular Subtype and a Prognosis-Related Signature.TIFF
Published 2021“…Cachexia-inducing factors (CIFs) have been reported in colorectal cancer and pancreatic adenocarcinoma, but their value in diffuse large B-cell lymphoma (DLBCL) requires further genetic research.…”
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Image_3_Comprehensive Characterization of Cachexia-Inducing Factors in Diffuse Large B-Cell Lymphoma Reveals a Molecular Subtype and a Prognosis-Related Signature.TIFF
Published 2021“…Cachexia-inducing factors (CIFs) have been reported in colorectal cancer and pancreatic adenocarcinoma, but their value in diffuse large B-cell lymphoma (DLBCL) requires further genetic research.…”
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Image_5_Comprehensive Characterization of Cachexia-Inducing Factors in Diffuse Large B-Cell Lymphoma Reveals a Molecular Subtype and a Prognosis-Related Signature.TIF
Published 2021“…Cachexia-inducing factors (CIFs) have been reported in colorectal cancer and pancreatic adenocarcinoma, but their value in diffuse large B-cell lymphoma (DLBCL) requires further genetic research.…”
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Image_10_Comprehensive Characterization of Cachexia-Inducing Factors in Diffuse Large B-Cell Lymphoma Reveals a Molecular Subtype and a Prognosis-Related Signature.TIFF
Published 2021“…Cachexia-inducing factors (CIFs) have been reported in colorectal cancer and pancreatic adenocarcinoma, but their value in diffuse large B-cell lymphoma (DLBCL) requires further genetic research.…”