An Enzyme with High Catalytic Proficiency Utilizes Distal Site Substrate Binding Energy to Stabilize the Closed State but at the Expense of Substrate Inhibition by Angus J. Robertson (11535072)

“…Here, we use β-phosphoglucomutase (βPGM) to investigate the relationship between binding a phosphodianion group in a distal site, the adoption of a closed enzyme form, and catalytic proficiency. βPGM catalyzes the isomerization of β-glucose 1-phosphate to glucose 6-phosphate via phosphoryl transfer reactions in the proximal site, while coordinating a phosphodianion group of the substrate(s) in a distal site. βPGM has one of the largest catalytic proficiencies measured and undergoes significant domain closure during its catalytic cycle. …”

An Enzyme with High Catalytic Proficiency Utilizes Distal Site Substrate Binding Energy to Stabilize the Closed State but at the Expense of Substrate Inhibition by Angus J. Robertson (11535072)

“…Here, we use β-phosphoglucomutase (βPGM) to investigate the relationship between binding a phosphodianion group in a distal site, the adoption of a closed enzyme form, and catalytic proficiency. βPGM catalyzes the isomerization of β-glucose 1-phosphate to glucose 6-phosphate via phosphoryl transfer reactions in the proximal site, while coordinating a phosphodianion group of the substrate(s) in a distal site. βPGM has one of the largest catalytic proficiencies measured and undergoes significant domain closure during its catalytic cycle. …”

An Enzyme with High Catalytic Proficiency Utilizes Distal Site Substrate Binding Energy to Stabilize the Closed State but at the Expense of Substrate Inhibition by Angus J. Robertson (11535072)

“…Here, we use β-phosphoglucomutase (βPGM) to investigate the relationship between binding a phosphodianion group in a distal site, the adoption of a closed enzyme form, and catalytic proficiency. βPGM catalyzes the isomerization of β-glucose 1-phosphate to glucose 6-phosphate via phosphoryl transfer reactions in the proximal site, while coordinating a phosphodianion group of the substrate(s) in a distal site. βPGM has one of the largest catalytic proficiencies measured and undergoes significant domain closure during its catalytic cycle. …”

An Enzyme with High Catalytic Proficiency Utilizes Distal Site Substrate Binding Energy to Stabilize the Closed State but at the Expense of Substrate Inhibition by Angus J. Robertson (11535072)

“…Here, we use β-phosphoglucomutase (βPGM) to investigate the relationship between binding a phosphodianion group in a distal site, the adoption of a closed enzyme form, and catalytic proficiency. βPGM catalyzes the isomerization of β-glucose 1-phosphate to glucose 6-phosphate via phosphoryl transfer reactions in the proximal site, while coordinating a phosphodianion group of the substrate(s) in a distal site. βPGM has one of the largest catalytic proficiencies measured and undergoes significant domain closure during its catalytic cycle. …”

Loss of ECRG4 expression decreases neutrophil mobilization from bone marrow reserves. by Katie D. Pool (20141584)

Stakeholders’ perception (% of interviewed) on the production conditions and yields of Brazil nut and Açai between 2010 and 2020 in the three research sites. by Paul Mathäss (21587593)

Classification table of vegetation coverage. by Ziheng Song (14380161)

“…The Open-pit mining affected areas showed the largest decline, reaching 68.3%. The <i>FVC</i> in the underground mining areas had a downward trend, but self-healing effect after mining was also observed. (2) The overall <i>FVC</i> in the study area was positively correlated with the number of precipitation days. (3) There were differences in the sensitivity to mining disturbance for different landform in the underground mining areas. (4) Although the <i>FVC</i> in the Old mining areas had recovered to the level of Natural growth control area, but the annual fluctuation was larger, which might mean lower ecological stability.…”

Vegetation coverage growth trend grading. by Ziheng Song (14380161)

“…The Open-pit mining affected areas showed the largest decline, reaching 68.3%. The <i>FVC</i> in the underground mining areas had a downward trend, but self-healing effect after mining was also observed. (2) The overall <i>FVC</i> in the study area was positively correlated with the number of precipitation days. (3) There were differences in the sensitivity to mining disturbance for different landform in the underground mining areas. (4) Although the <i>FVC</i> in the Old mining areas had recovered to the level of Natural growth control area, but the annual fluctuation was larger, which might mean lower ecological stability.…”

Information of Landsat data for validation. by Ziheng Song (14380161)

“…The Open-pit mining affected areas showed the largest decline, reaching 68.3%. The <i>FVC</i> in the underground mining areas had a downward trend, but self-healing effect after mining was also observed. (2) The overall <i>FVC</i> in the study area was positively correlated with the number of precipitation days. (3) There were differences in the sensitivity to mining disturbance for different landform in the underground mining areas. (4) Although the <i>FVC</i> in the Old mining areas had recovered to the level of Natural growth control area, but the annual fluctuation was larger, which might mean lower ecological stability.…”

Information of GaoFen data selected. by Ziheng Song (14380161)

“…The Open-pit mining affected areas showed the largest decline, reaching 68.3%. The <i>FVC</i> in the underground mining areas had a downward trend, but self-healing effect after mining was also observed. (2) The overall <i>FVC</i> in the study area was positively correlated with the number of precipitation days. (3) There were differences in the sensitivity to mining disturbance for different landform in the underground mining areas. (4) Although the <i>FVC</i> in the Old mining areas had recovered to the level of Natural growth control area, but the annual fluctuation was larger, which might mean lower ecological stability.…”

S1 Data - by Jordan K. Abbott (8934239)

Subjects:

Nightlight densities in the lowest, around the median and the highest ranked cities in the sample and the distribution of firms in each city. by Saul Estrin (8629173)

The MAP region, and the three research-sites: southern Acre, Brazil, eastern Pando, Bolivia and the southwestern Madre de Dios, Peru. by Paul Mathäss (21587593)

<i>FVC</i> variation based on Landsat and GaoFen satellites. by Ziheng Song (14380161)

DataSheet_1_Albinism in the largest extant amphibian: A metabolic, endocrine, or immune problem?.pdf by Liming Chang (2847938)

“…Albino individuals exhibited shifted transcription of MHC I isotypes, and the albino-specific isotype was characterized by increased charges and decreased space in the antigen- binding pocket, implying a drastic change in antigen specificity and a potential risk of autoimmune disorders.…”

Morphology Control of Lanthanide Doped NaGdF₄ Nanocrystals via One-Step Thermolysis by Miao Wang (248377)

Blocking the MAPK pathway with UO126 decreases jagged expression and migratory ability. by Megan K. Fentress (17304814)

The model develops larger place fields with shallower phase precession in areas of higher running speed. by Eloy Parra-Barrero (15461005)

GI-1d-a: Comparison of estimates of people for dataset A (left bar) and B (right bar) per region. The largest discrepancies occur in areas of NE, SE and SW Germany and adjacent reg... by Isabell Schmidt (6331013)

Population changes of <i>M</i>. <i>bavaricum</i> (a) and cocci (b) in Earth’s field (red symbols), zero field (black symbols) and alternating field (blue symbols) as a function of... by Xuegang Mao (599968)