Characterizing the Effect of Arginine Deprivation on Autophagic Response in Breast Cancer cells حسب Haidar, Fatemah

"…Residual ASS1 tumor expression corelated with increased metastasis and decreased survival in patient luminal A, Her2+ and triple-negative breast cancer. …"
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DNAJB3/HSP-40 cochaperone improves insulin signaling and enhances glucose uptake in vitro through JNK repression حسب Mohamed Abu-Farha (25322)

"…<p dir="ltr">Heat shock response (HSR) is an essential host-defense mechanism that is dysregulated in obesity-induced insulin resistance and type 2 diabetes (T2D). …"

Thermal Management System Optimization for Electronics Using Loop Heat Pipe, Guided by Hybrid Heat-Sink Benchmarks, to Enhance Energy Efficiency and Sustainability حسب Morsi, Kareem

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DNAJB3 attenuates metabolic stress and promotes glucose uptake by eliciting Glut4 translocation حسب Abdelilah Arredouani (10914455)

"…<p>Failure of the heat shock response is a key event that leads to insulin resistance and type 2 diabetes. …"

Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle حسب Jinit, Masania

"…Mice with ectopic expression of uncoupling protein-1 (UCP1) in skeletal muscle exhibit a healthy aging phenotype with increased longevity and resistance to impaired metabolic health. …"
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Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle حسب Jinit Masania (7164239)

"…<p dir="ltr">Mice with ectopic expression of uncoupling protein-1 (UCP1) in skeletal muscle exhibit a healthy aging phenotype with increased longevity and resistance to impaired metabolic health. …"

Investigating the Therapeutic Effects of Small Molecule Imipridones In Pediatric Neuroblastoma حسب El Soussi, Sarra

"…Our findings demonstrate an important multi-target effect of imipridones that may yield added therapeutic benefits in treating this devastating cancer.…"
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DNAJB3 attenuates ER stress through direct interaction with AKT حسب Zeyaul Islam (5867387)

"…<p dir="ltr">Metabolic stress involved in several dysregulation disorders such as type 2 diabetes mellitus (T2DM) results in down regulation of several heat shock proteins (HSPs) including DNAJB3. This down regulation of HSPs is associated with insulin resistance (IR) and interventions which induce the heat shock response (HSR) help to increase the insulin sensitivity. …"

Optimizing clopidogrel dose response حسب Saab, Yolande B.

"…Results The study results show that all patients under clopidogrel treatment, whose genotypes are different from *1*1, and concomitantly taking other drugs metabolized by CYP2C19 require clopidogrel dose adjustment. To get a therapeutic effect and avoid adverse drug reactions, therapeutic dose of 75 mg clopidogrel, for example, should be lowered to 6 mg or increased to 215 mg in patients with different genotypes. …"
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Skin responses to fractional photothermolysis حسب Tannous, Zeina

"…Background and Objective Fractional photothermolysis (FP) is a new concept using arrays of microscopic thermal damage patterns to stimulate a therapeutic response. We analyzed epidermal and dermal response to FP with the aim of correlating histological and clinical response. …"
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P-glycoprotein expression and function are increased in an animal model of amyotrophic lateral sclerosis حسب Milane, Aline

"…The lack of response to treatment in ALS may be, at least in part, due to increased activities of efflux pumps in relation to disease, leading to subtherapeutic brain concentrations of drugs. …"
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Immunohistochemical profiling of the heat shock response in obese non-diabetic subjects revealed impaired expression of heat shock proteins in the adipose tissue حسب Ali Tiss (437068)

"…<p dir="ltr">Obesity is characterized by a chronic low-grade inflammation and altered stress responses in key metabolic tissues. Impairment of heat shock response (HSR) has been already linked to diabetes and insulin resistance as reflected by decrease in heat shock proteins (HSPs) expression. …"

Role of the gut microbiota in the pathogenesis of coeliac disease and potential therapeutic implications حسب Anthony K. Akobeng (7713470)

"…Dysbiotic microbiota may lead to a dysregulated immune response that may contribute to the pathogenesis of coeliac disease. …"

Emerging Glycation-Based Therapeutics—Glyoxalase 1 Inducers and Glyoxalase 1 Inhibitors حسب Naila Rabbani (291722)

"…Increased MG glycation produces inactivation and misfolding of proteins, cell dysfunction, activation of the unfolded protein response, and related low-grade inflammation. …"

Decoding the Therapeutic Potential of [HuArgI (Co)-PEG5000] Arginase Treatment حسب Zeineddine, Mira

"…Moreover, our study results lay the groundwork for the creation of innovative combination treatments that specifically target different facets of cancer cell behavior, offering patients with breast cancer better prognoses and increased therapeutic efficacy.…"
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Welding of Semiconductor Nanowires by Coupling Laser-Induced Peening and Localized Heating حسب Kelly M. Rickey (19568770)

"…The morphology results show that laser peening can decrease porosity and bring nanowires into contact and pulsed laser heating fuses those contacts. …"

FoxP3⁺ T regulatory cells in cancer: Prognostic biomarkers and therapeutic targets حسب Reem Saleh (3513056)

"…They maintain immune homeostasis and inhibit immune responses in various diseases, including cancer. Proportions of Tregs in the peripheral blood of some cancer patients increase by approximately two-fold, compared to those in healthy individuals. …"

Ultrasound-responsive Nanocarriers in Cancer Treatment: a review حسب Awad, Nahid S.

"…Using smart nanocarriers, the rate of release of the entrapped therapeutic(s) can be increased, and greater exposure of the tumor cells to the therapeutics can be achieved when the nanocarriers are exposed to certain internally (enzymes, pH and temperature) or externally applied (light, magnetic field, and ultrasound) stimuli that trigger the release of their load in a safe and controlled manner, spatially and temporally. …"
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The Obesity Paradox in Cancer, Tumor Immunology, and Immunotherapy: Potential Therapeutic Implications in Triple Negative Breast Cancer حسب Adviti Naik (673163)

Recombinant Adeno-Associated Virus-Mediated In Utero Gene Transfer Gives Therapeutic Transgene Expression in the Sheep حسب Abi Nader, Khalil

"…This is the first study to show therapeutic long-term hFIX transgene expression after in utero gene transfer in a large animal model.…"
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