iPSCs derived from insulin resistant offspring of type 2 diabetic patients show increased oxidative stress and lactate secretion by Bushra Memon (4792767)

“…IR-iPSCs have increased cellular oxidative stress indicated by a high production of reactive oxygen species and higher susceptibility to H2O2 -induced apoptosis.…”

Effect of Flexural CFRP Sheets and Plates on Shear Resistance of Reinforced Concrete Beams by Nawaz, Waleed

Get full text

Deletion of the Candida albicans PIR32 Results in Increased Virulence, Stress Response, and Upregulation of Cell Wall Chitin Deposition by Bahnan, Wael

“…The purpose of this study is to characterize Pir32 by generating a homozygous null strain and comparing the phenotype of the null with that of the wild-type parental strain as far as filamentation, virulence in a mouse model of disseminated candidiasis, resistance to oxidative stress and cell wall disrupting agents, in addition to adhesion, biofilm capacities, and cell wall chitin content. …”
Get full text
Get full text
Get full text

DNAJB3 attenuates ER stress through direct interaction with AKT by Zeyaul Islam (5867387)

“…This down regulation of HSPs is associated with insulin resistance (IR) and interventions which induce the heat shock response (HSR) help to increase the insulin sensitivity. …”

Alpha lipoic acid attenuates ER stress and improves glucose uptake through DNAJB3 cochaperone by Abdoulaye Diane (14152749)

“…<p dir="ltr">Persistent ER stress, mitochondrial dysfunction and failure of the heat shock response (HSR) are fundamental hallmarks of insulin resistance (IR); one of the early core metabolic aberrations that leads to type 2 diabetes (T2D). …”

Effect of Basalt Microfiber on the Shear Response of RC Short Beams by Sabbagh, Mohamad Kusay Ahmad Rabee

Get full text

Behaviour of Shear Deficient Reinforced Concrete Beams with Externally Bonded Aluminum Plates by Abu-Obeidah, Adi Salman

Get full text

Effect of Blended Lightweight and Normal Weight Aggregates on The Shear Capacity of Concrete Beams by Khalil, Khalid Hesham

Get full text

Dicarbonyl stress, protein glycation and the unfolded protein response by Naila Rabbani (291722)

“…<p>The reactive dicarbonyl metabolite, methylglyoxal (MG), is increased in obesity and diabetes and is implicated in the development of insulin resistance, type 2 diabetes mellitus and vascular complications of diabetes. …”

Alleviation of drought and salt stress in vegetables: crop responses and mitigation strategies by Muhammad Fasih Khalid (10652246)

“…Climate change has affected vegetable production by increasing the frequencies and severity of abiotic and biotic stresses. …”

A Novel Steel Reinforcement Scheme for 3D Printed Concrete Beams: A Study on Shear Behaviour by Khalifa, Mohamed Ashraf

Get full text

Multi-Objective Optimisation of Injection Moulding Process for Dashboard Using Genetic Algorithm and Type-2 Fuzzy Neural Network by Mohammad Reza Chalak Qazani (13893261)

“…Its purpose was to estimate shear and residual stress levels. Additionally, the multi-objective genetic algorithm (MOGA) was utilised to extract the most optimal parameters for the injection moulding process, aiming to minimise shear and residual stress and thereby increase the resistance of the final product. …”

Sensitivity analysis and genetic algorithm-based shear capacity model for basalt FRC one-way slabs reinforced with BFRP bars by Abathar Al-Hamrani (16494884)

“…<p dir="ltr">Fiber-reinforced polymer (FRP) composites are increasingly used in concrete structures owing to their superior corrosion resistance. …”

Genetic Deletion of DNAJB3 Using CRISPR-Cas9, Produced Discordant Phenotypes by Shadi Nejat (19457212)

“…<p dir="ltr">Several pathways and/or genes have been shown to be dysregulated in obesity-induced insulin resistance (IR) and type 2 diabetes (T2D). We previously showed, for the first time, impaired expression of DNAJB3 mRNA and protein in subjects with obesity, which was concomitant with increased metabolic stress. …”

Proteomic Characterization Of Clinical Candida glabrata Isolates With Varying Degrees Of Virulence And Resistance To Fluconazole by Zeidan, Ahmad

“…Azoles work by inhibiting the Erg11 enzyme altering the conversion of lanosterol to ergosterol, the main sterol found in fungi. Resistance to azoles is increasing among Candida species worldwide, and in Lebanon. …”
Get full text
Get full text
Get full text

Biochemical Characterization of Halotolerant Bacillus safensis PM22 and Its Potential to Enhance Growth of Maize under Salinity Stress by Muhammad Atif Azeem (17542080)

“…Additionally, inoculation of the halotolerant bacteria PM22 reduced the severity of salinity stress in plants and increased root and shoot length at various salt concentrations (0, 180, 240, and 300 mM). …”

Hexokinase-2-Linked Glycolytic Overload and Unscheduled Glycolysis—Driver of Insulin Resistance and Development of Vascular Complications of Diabetes by Naila Rabbani (291722)

“…<div><p>The recent discovery of the glucose-induced stabilization of hexokinase-2 (HK2) to proteolysis in cell dysfunction in model hyperglycemia has revealed a likely key initiating factor contributing to the development of insulin resistance and vascular complications in diabetes. Consequently, the increased flux of glucose metabolism without a change in the expression and activity of glycolytic enzymes produces a wave of increased glycolytic intermediates driving mitochondrial dysfunction and increased reactive oxygen species (ROS) formation, the activation of hexosamine and protein kinase C pathways, the increased formation of methylglyoxal-producing dicarbonyl stress, and the activation of the unfolded protein response. …”

Hexokinase-linked glycolytic overload and unscheduled glycolysis in hyperglycemia-induced pathogenesis of insulin resistance, beta-cell glucotoxicity, and diabetic vascular complic... by Naila Rabbani (291722)

“…Downstream effector pathways of HK-linked unscheduled glycolysis are mitochondrial dysfunction and increased reactive oxygen species (ROS) formation; activation of hexosamine, protein kinase c, and dicarbonyl stress pathways; and increased Mlx/Mondo A signaling. …”

Soil Characterization Utilizing GPR Technique by Al Kej, Fateh Tamam

Get full text

Immunohistochemical profiling of the heat shock response in obese non-diabetic subjects revealed impaired expression of heat shock proteins in the adipose tissue by Ali Tiss (437068)

“…<p dir="ltr">Obesity is characterized by a chronic low-grade inflammation and altered stress responses in key metabolic tissues. Impairment of heat shock response (HSR) has been already linked to diabetes and insulin resistance as reflected by decrease in heat shock proteins (HSPs) expression. …”