Recent Advances in Nanoparticle-Based Co-Delivery Systems for Cancer Therapy حسب Al Bostami, Rouba D.

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iPSCs derived from insulin resistant offspring of type 2 diabetic patients show increased oxidative stress and lactate secretion حسب Bushra Memon (4792767)

"…Therefore, in this study, we aimed to investigate the genetic perturbations associated with insulin resistance (IR) in the offspring of T2D parents using patient-specific iPSCs.…"

Cancer cell plasticity: from cellular, molecular, and genetic mechanisms to tumor heterogeneity and drug resistance حسب Gh Rasool Bhat (13038132)

"…Despite significant advancements in targeted therapies, cancer cell adaptability and subsequent therapy-induced resistance remain persistent obstacles in achieving consistent, successful cancer treatment outcomes. …"

Emerging therapies in multiple myeloma حسب El-Amm, Joelle

"…However, despite the increased effectiveness of the first-line agents, the majority of patients will eventually relapse and become drug resistant. …"
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E3 Ubiquitin Ligase <i>TRIP12</i> Controls Exit from Mitosis via Positive Regulation of <i>MCL-1</i> in Response to Taxol حسب Kripa S. Keyan (17807771)

Natural products as chemo-radiation therapy sensitizers in cancers حسب Sabah Nisar (12561961)

"…Surgery, chemotherapy (CT), and/or radiation therapy (RT) are the treatment of choice for most advanced tumors. …"

Epigenetic and breast cancer therapy: Promising diagnostic and therapeutic applications حسب Gulab Sher (12984698)

The changing landscape in the treatment of metastatic castration-resistant prostate cancer حسب El Amm, Joelle

"…The past few years have brought increasing advances in the therapeutic management of metastatic castration-resistant prostate cancer with the approval of several agents, including vaccine therapy with sipuleucel-T, second-line chemotherapy with cabazitaxel, the bone-targeted pharmaceutical denosumab, and the novel antiandrogen therapy abiraterone acetate. …"
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Cisplatin based therapy: the role of the mitogen activated protein kinase signaling pathway حسب Iman W. Achkar (4246141)

"…A Combination of cisplatin with other drugs is an approach to overcome drug resistance and reduce toxicity. The combination therapy also results in increased sensitivity of cisplatin towards cancer cells. …"

In vitro ischemia suppresses hypoxic induction of hypoxia-inducible factor-1α by inhibition of synthesis and not enhanced degradation حسب Sleiman, Sama F.

"…Hypoxia-inducible factor (HIF) mediates a broad, conserved adaptive response to hypoxia, and the HIF pathway is a potential therapeutic target in cerebral ischemia. …"
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Cytokine-chemokine network driven metastasis in esophageal cancer; promising avenue for targeted therapy حسب Ajaz A. Bhat (12984701)

"…<div><p>Esophageal cancer (EC) is a disease often marked by aggressive growth and poor prognosis. Lack of targeted therapies, resistance to chemoradiation therapy, and distant metastases among patients with advanced disease account for the high mortality rate. …"

The evolving role of extracellular vesicles (exosomes) as biomarkers in traumatic brain injury: Clinical perspectives and therapeutic implications حسب Naushad Ahmad Khan (6406973)

"…Some studies showed that TBI is a risk factor for different NDs. In terms of therapeutic potential, EVs outperform the alternative synthetic drug delivery methods because they can transverse the blood–brain barrier (BBB) without inducing immunogenicity, impacting neuroinflammation, immunological responses, and prolonged bio-distribution. …"

The effect of microbiome therapy on COVID-19-induced gut dysbiosis: A narrative and systematic review حسب Mahmoud Yousef (9900837)

"…Noteworthy prebiotics employed in these studies included chestnut tannin, galactooligosaccharides, fructooligosaccharides, xylooligosaccharide, and resistant dextrin. The majority of the investigated biotics exhibited positive effects on COVID-19 patients, manifesting in symptom alleviation, inflammation reduction, and notable decreases in mortality rates. …"

Empiric antibiotic therapy of community-acquired Pneumonia at the American University of Beirut Medical Center. (c2001) حسب Cherfan, Antoine

"…The emergence of resistance among Streptococcus pneumoniae strains have led to the development of several guidelines for the treatment of community-acquired Pneumonia (CAP). …"
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Candida albicans identification and microsatellite DNA genotyping of Lebanese clinical isolates. (c2007) حسب Barada, Ghyda Ali

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Integrated transcriptional‐phenotypic analysis captures systemic immunomodulation following antiangiogenic therapy in renal cell carcinoma patients حسب Darawan Rinchai (742366)

"…<h3>Background</h3><p dir="ltr">The combination of immune checkpoint blockade (ICB) with standard therapies is becoming a common approach for overcoming resistance to cancer immunotherapy in most human malignancies including metastatic renal cell carcinoma (mRCC). …"

Efficacy of Cannabidiol Combination with Cisplatin or Paclitaxel against Platinum-Resistant Ovarian Cancer Cell Lines حسب Ismail, Jana

"…The results suggest the potential benefit of sequential, rather than simultaneous, administration of CBD and chemotherapy to enhance therapy and overcome resistance. These findings, while demonstrating the potential benefit of CBD in treating ovarian cancer, call for additional caution when combining it with chemotherapeutic agents, specifically cisplatin and paclitaxel, as the effect is shown to be cell line and drug specific. …"
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Rapid generation of purified human RPE from pluripotent stem cells using 2D cultures and lipoprotein uptake-based sorting حسب Fabio Michelet (8396283)

"…<h3>Background</h3><p dir="ltr">Despite increasing demand, current protocols for human pluripotent stem cell (hPSC)-derived retinal pigment epithelium (RPE) remain time, labor, and cost intensive. …"

Screening for antiretroviral drug resistance among treatment-naive human immunodeficiency virus type 1-infected individuals in Lebanon حسب Mokhbat, Jacques M.

"…Introduction: Antiretroviral therapy (ART) has been successful at decreasing the morbidity and mortality associated with human immunodeficiency virus type 1 (HIV-1) infection. …"
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Molecular characterization of extended-spectrum beta-lactamase producing escherichia coli. (c2014) حسب Cheaito, Katia Anis

"…These results agree with previously published studies in Lebanon and worldwide and highlight the increasing incidence and dissemination of these pathogens in the hospital and community setting and draws attention to the broadening of resistance among ESBLs whereby therapy alternatives are becoming scarce.…"
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