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iPSCs derived from insulin resistant offspring of type 2 diabetic patients show increased oxidative stress and lactate secretion
منشور في 2022"…IR-iPSCs have increased cellular oxidative stress indicated by a high production of reactive oxygen species and higher susceptibility to H2O2 -induced apoptosis.…"
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A potential therapeutic agent for sickle cell anaemia
منشور في 2016"…They also found increased levels of ROS that were associated with decreased levels of antioxidant enzymes and their co-factors.…"
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Cancer cell plasticity: from cellular, molecular, and genetic mechanisms to tumor heterogeneity and drug resistance
منشور في 2024"…Despite significant advancements in targeted therapies, cancer cell adaptability and subsequent therapy-induced resistance remain persistent obstacles in achieving consistent, successful cancer treatment outcomes. …"
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Emerging therapies in multiple myeloma
منشور في 2015"…However, despite the increased effectiveness of the first-line agents, the majority of patients will eventually relapse and become drug resistant. …"
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Natural products as chemo-radiation therapy sensitizers in cancers
منشور في 2022"…Surgery, chemotherapy (CT), and/or radiation therapy (RT) are the treatment of choice for most advanced tumors. …"
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Cisplatin based therapy: the role of the mitogen activated protein kinase signaling pathway
منشور في 2018"…A Combination of cisplatin with other drugs is an approach to overcome drug resistance and reduce toxicity. The combination therapy also results in increased sensitivity of cisplatin towards cancer cells. …"
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The changing landscape in the treatment of metastatic castration-resistant prostate cancer
منشور في 2012"…The past few years have brought increasing advances in the therapeutic management of metastatic castration-resistant prostate cancer with the approval of several agents, including vaccine therapy with sipuleucel-T, second-line chemotherapy with cabazitaxel, the bone-targeted pharmaceutical denosumab, and the novel antiandrogen therapy abiraterone acetate. …"
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Nasturtium officinalis water extract. (c2009)
منشور في 2009احصل على النص الكامل
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Integrated transcriptional‐phenotypic analysis captures systemic immunomodulation following antiangiogenic therapy in renal cell carcinoma patients
منشور في 2021"…<h3>Background</h3><p dir="ltr">The combination of immune checkpoint blockade (ICB) with standard therapies is becoming a common approach for overcoming resistance to cancer immunotherapy in most human malignancies including metastatic renal cell carcinoma (mRCC). …"