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The emergence of new SARS-CoV-2 variant (Omicron) and increasing calls for COVID-19 vaccine boosters-The debate continues
منشور في 2022"…The emergence of these VOCs (Alpha, Beta, Gamma, and Delta) variants was responsible for new waves of infections across the entire world [3]. The Delta variant was reported to have increased transmissibility, higher viral load [4] and high rates of reinfection [5]. …"
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Epidemiological, Molecular, and Clinical Features of Norovirus Infections among Pediatric Patients in Qatar
منشور في 2019"…NoV infections occurred throughout the year, with a noticeable increase in summer (36.6%) and drop in winter (25.4%). …"
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Emtricitabine/rilpivirine/tenofovir disoproxil fumarate for the treatment of HIV-1 infection in adults
منشور في 2015"…Results from two phase 3 randomized double blind trials (ECHO and THRIVE) showed that rilpivirine is non-inferior to efavirenz in suppressing viral load below 50 copies/mL in anti-retroviral therapy (ART) naïve human immunodeficiency virus (HIV) infected patients. …"
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Impact of the positive pressure valve on vascular access device occlusions and bloodstream infections
منشور في 2009"…Background/Purpose The use of needleless positive pressure connector valves (PPVs) on venous access devices (VADs) has been shown to have possible benefits in decreasing VAD occlusion rates. Catheter-related bloodstream infection (CRBSI) rates, however, have been variable. …"
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Vulnerabilities of the SARS-CoV-2 Virus to Proteotoxicity—Opportunity for Repurposed Chemotherapy of COVID-19 Infection
منشور في 2020"…A strategy for improved drug therapy is to increase levels of endogenous reactive metabolites for selective toxicity to SARS-CoV-2 by preferential damage to the viral proteome. …"
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Brain microstructural changes support cognitive deficits in HIV uninfected children born to HIV infected mothers
منشور في 2020"…Decreased FA along with both increased and decreased MD in different brain regions was present in HUC compared to CHNM. …"
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Topical Vancomycin for Prevention of Surgical Site Infection after Craniotomy: Meta-analysis and Systematic Literature Review
منشور في 2022"…</p><h3>Methods</h3><p dir="ltr">Multiple electronic health databases were searched to identify all the studies published from July 1988 to July 2021 that examined the role of application of topical vancomycin in reduction of the risk of surgical site infection after craniotomy (cSSIs). Effect sizes were expressed in pooled odds ratio (OR) estimates and, because of heterogeneity between studies, random effect of the inverse variance weighted method was used to perform the meta-analysis.…"
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SARS‐CoV‐2 infection and effects of age, sex, comorbidity, and vaccination among older individuals: A national cohort study
منشور في 2023"…Risk of infection varied minimally by age and sex but increased significantly with coexisting conditions. …"
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CFD Analyses: The Effect of Pressure Suction and Airflow Velocity on Coronavirus Dispersal
منشور في 2021"…<div><p>Hospital emergency departments (EDs) are hubs for highly transmissible infectious diseases, posing the highest risk of viral infection transmission. With the current COVID-19 outbreak, it has become clear that the ED design needs to be altered in order to be successful in containing the pandemic. …"
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Impact of COVID‑19 pandemic restrictions and subsequent relaxation on the prevalence of respiratory virus hospitalizations in children
منشور في 2024"…An increase in viral ALRTI hospitalizations accompanied by a resurgence of RSV circulation following the relaxation of COVID-19 restrictions was observed without changes in disease severity.…"
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Airflow dynamics in an emergency department: A CFD simulation study to analyse COVID-19 dispersion
منشور في 2021"…<p>Emergency departments (EDs) in hospitals are hotspots for highly transmissible infectious diseases and pose the most significant risk of viral infection spreading. With the recent COVID-19 outbreak, it became clear that emergency department design must evolve in order to be adequately prepared to handle the epidemic. …"
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Burden and disease pathogenesis of influenza and other respiratory viruses in diabetic patients
منشور في 2022"…Since influenza is the most common respiratory infection, DM patients experience disease severity and increased hospitalization during influenza season. …"
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The relationship of soluble neuropilin-1 to severe COVID-19 risk factors in polycystic ovary syndrome
منشور في 2021"…<p dir="ltr">The SARS-CoV-2 coronavirus enters target cells via the angiotensin-converting enzyme 2 (ACE2) receptor; however, ACE2 expression does not match SARS-CoV-2 tissue load, suggesting additional co-factors are required for viral entry [1]. Neuropilin-1 (NRP1) is such a co-factor that, when expressed alone shows minimal viral infectivity, but when co-expressed with ACE2 markedly increases viral infectivity [1]. …"
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SARS-CoV-2 Variants in Lebanon
منشور في 2024"…Variants of concern (VOC) included Alpha, Beta, Delta, Gamma, and most recently Omicron. Co-infections of SARS-CoV-2 with influenza viruses were detected and led to increased infectivity and SARS-CoV-2 viral load. …"
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Managing Endothelial Dysfunction in COVID-19
منشور في 2022"…However, this treatment protocol was associated with an excellent safety profile. Adequately sized prospective randomized controlled trials are needed for the evaluation of the role of treating endothelial dysfunction in COVID-19 infection.…"
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A Novel STK4 Mutation Impairs T Cell Immunity Through Dysregulation of Cytokine-Induced Adhesion and Chemotaxis Genes
منشور في 2021"…</p><h3>Results</h3><p dir="ltr">The patient exhibited partial loss of STK4 expression and complete loss of STK4 function combined with recurrent viral and bacterial infections, notably persistent Epstein–Barr virus viremia and pulmonary tuberculosis. …"