Discovery of Arylsulfonamides as Dual Orexin Receptor Agonists by Dehui Zhang (1332363)

“…Several OX2R agonists have been reported but with little or no activity at OX1R. We conducted structure–activity relationship studies on the OX2R agonist YNT-185 (<b>2</b>) and discovered dual agonists such as RTOXA-43 (<b>40</b>) with EC₅₀’s of 24 nM at both OX2R and OX1R. …”

Chemotherapy Drug Induced Discoordination of Mitochondrial Life Cycle Detected by Cardiolipin Fluctuation by Yu-Jen Chao (665872)

“…<div><p>Chemotherapy drugs have been prescribed for the systemic treatment of cancer. We selected three chemotherapy drugs, including methotrexate, mitomycine C and vincristine to inhibit the proliferation of HT1080 human fibrosarcoma cells in S, G2 and M phases of the cell cycle respectively. …”

Data_Sheet_1_Public Database-Driven Insights Into Aging Stress-Associated Defective Gut Barrier With Low SARS-CoV-2 Receptors.PDF by Yuseok Moon (4877827)

“…In the present study, we assessed aging-associated gut transcriptomic responses considering the gastrointestinal symptoms contributing to COVID-19 severity. …”

Particle Imaging Velocimetry Evaluation of Intracranial Stents in Sidewall Aneurysm: Hemodynamic Transition Related to the Stent Design by Pierre Bouillot (668911)

“…<div><p>We investigated the flow modifications induced by a large panel of commercial-off-the-shelf (COTS) intracranial stents in an idealized sidewall intracranial aneurysm (IA). …”

Alterations in Hippocampal Oxidative Stress, Expression of AMPA Receptor GluR2 Subunit and Associated Spatial Memory Loss by <i>Bacopa monnieri</i> Extract (CDRI-08) in Streptozoto... by Surya P. Pandey (768295)

“…However, the precise molecular mechanism of the role of CDRI-08, a well characterized fraction of <i>Bacopa monnieri</i> extract, in recovery of the diabetes mellitus-induced memory impairments is not known. Here, we demonstrate that DM2 mice treated orally with lower dose of CDRI-08 (50- or 100 mg/kg BW) is able to significantly enhance spatial memory in STZ-DM2 mice and this is correlated with a significant decline in oxidative stress and up regulation of the AMPA receptor GluR2 subunit gene expression in the hippocampus. …”

Reappraisal of the Trophic Ecology of One of the World’s Most Threatened Spheniscids, the African Penguin by Maëlle Connan (680842)

“…These represent over 50% of the world population. Various samples (blood, feathers, egg membranes) were collected for carbon and nitrogen stable isotope analyses. …”

Discovery of Arylsulfonamides as Dual Orexin Receptor Agonists by Dehui Zhang (1332363)

“…Several OX2R agonists have been reported but with little or no activity at OX1R. We conducted structure–activity relationship studies on the OX2R agonist YNT-185 (<b>2</b>) and discovered dual agonists such as RTOXA-43 (<b>40</b>) with EC₅₀’s of 24 nM at both OX2R and OX1R. …”

Discovery of Arylsulfonamides as Dual Orexin Receptor Agonists by Dehui Zhang (1332363)

“…Several OX2R agonists have been reported but with little or no activity at OX1R. We conducted structure–activity relationship studies on the OX2R agonist YNT-185 (<b>2</b>) and discovered dual agonists such as RTOXA-43 (<b>40</b>) with EC₅₀’s of 24 nM at both OX2R and OX1R. …”

Data_Sheet_1_Effectiveness and Safety of DOACs vs. VKAs in AF Patients With Cancer: Evidence From Randomized Clinical Trials and Observational Studies.PDF by Fuwei Liu (4447765)

“…For the effectiveness outcomes, the use of DOACs compared with VKAs use was significantly associated with decreased risks of stroke or systemic embolism (RR = 0.66, 95% CI: 0.54–0.80) and venous thromboembolism (RR = 0.40, 95% CI: 0.26–0.61), but not ischemic stroke (RR = 0.79, 95% CI: 0.56–1.11), myocardial infarction (RR = 0.78, 95% CI: 0.56–1.11), cardiovascular death (RR = 0.76, 95% CI: 0.53–1.09), and all-cause death (RR = 0.82, 95% CI: 0.43–1.56). …”

Fatty acid qualitative profile in <i>Symbiodinium</i> cells submitted or not to seawater acidification. by Lilian J. Hill (7134752)

“…The decrease of species number was evident in the acidified condition after 16 days (T4), in comparison to T0 and T4 of control condition.…”

Chill-coma recovery time of <i>Bicyclus anynana</i> in relation to hardening temperature. by Klaus Fischer (82645)

“…<p>We predicted that colder hardening temperatures increase but warmer hardening temperatures decrease cold resistance. While hardening temperature indeed affected recovery time (F_4,229 = 3.08, p = 0.0169), both high and low hardening temperatures increased recovery times (6°C = 34°C≥13°C = 27°C (control) ≥20°C; Tukey HSD after ANOVA). …”

Correlation between metabolites and brain damage. by Matthias Keller (150331)

“…Light grey corresponds to metabolites that were not found to be significant at FDR0.1.</p>…”

Number of each mosquito species captured by baited and unbaited CDC light traps at two districts in Kenya. by David P. Tchouassi (103894)

Algorithm to treatment of HLA-B27 associated uveitis. by Nabil Bouzid (8648571)

Change in content of cell wall components in <i>bm1</i> and <i>bm3</i> Maize mutants. by Rajib Saha (125339)

(Twitter) percentage changes in terms of engagement with posts. by Matteo Cinelli (8575176)

The comparison of the alarm pheromone model results and the experiment outcomes from Fig.2. by Geng Li (312002)

Theoretical model. by Luis Carlos Dominguez (5328461)

Non-metric Multi Dimensional Scaling (nMDS) ordination comparing interviews outputs across the different study locations. by Ernesto Azzurro (343590)

Results of clotting assays and network efficiency. by Qian Li (114642)