Discovery of Arylsulfonamides as Dual Orexin Receptor Agonists by Dehui Zhang (1332363)

“…Several OX2R agonists have been reported but with little or no activity at OX1R. We conducted structure–activity relationship studies on the OX2R agonist YNT-185 (<b>2</b>) and discovered dual agonists such as RTOXA-43 (<b>40</b>) with EC₅₀’s of 24 nM at both OX2R and OX1R. …”

Chemotherapy Drug Induced Discoordination of Mitochondrial Life Cycle Detected by Cardiolipin Fluctuation by Yu-Jen Chao (665872)

“…<div><p>Chemotherapy drugs have been prescribed for the systemic treatment of cancer. We selected three chemotherapy drugs, including methotrexate, mitomycine C and vincristine to inhibit the proliferation of HT1080 human fibrosarcoma cells in S, G2 and M phases of the cell cycle respectively. …”

Data_Sheet_1_Public Database-Driven Insights Into Aging Stress-Associated Defective Gut Barrier With Low SARS-CoV-2 Receptors.PDF by Yuseok Moon (4877827)

“…In the present study, we assessed aging-associated gut transcriptomic responses considering the gastrointestinal symptoms contributing to COVID-19 severity. …”

Particle Imaging Velocimetry Evaluation of Intracranial Stents in Sidewall Aneurysm: Hemodynamic Transition Related to the Stent Design by Pierre Bouillot (668911)

“…<div><p>We investigated the flow modifications induced by a large panel of commercial-off-the-shelf (COTS) intracranial stents in an idealized sidewall intracranial aneurysm (IA). …”

Alterations in Hippocampal Oxidative Stress, Expression of AMPA Receptor GluR2 Subunit and Associated Spatial Memory Loss by <i>Bacopa monnieri</i> Extract (CDRI-08) in Streptozoto... by Surya P. Pandey (768295)

“…However, the precise molecular mechanism of the role of CDRI-08, a well characterized fraction of <i>Bacopa monnieri</i> extract, in recovery of the diabetes mellitus-induced memory impairments is not known. Here, we demonstrate that DM2 mice treated orally with lower dose of CDRI-08 (50- or 100 mg/kg BW) is able to significantly enhance spatial memory in STZ-DM2 mice and this is correlated with a significant decline in oxidative stress and up regulation of the AMPA receptor GluR2 subunit gene expression in the hippocampus. …”

Reappraisal of the Trophic Ecology of One of the World’s Most Threatened Spheniscids, the African Penguin by Maëlle Connan (680842)

“…These represent over 50% of the world population. Various samples (blood, feathers, egg membranes) were collected for carbon and nitrogen stable isotope analyses. …”

Discovery of Arylsulfonamides as Dual Orexin Receptor Agonists by Dehui Zhang (1332363)

“…Several OX2R agonists have been reported but with little or no activity at OX1R. We conducted structure–activity relationship studies on the OX2R agonist YNT-185 (<b>2</b>) and discovered dual agonists such as RTOXA-43 (<b>40</b>) with EC₅₀’s of 24 nM at both OX2R and OX1R. …”

Discovery of Arylsulfonamides as Dual Orexin Receptor Agonists by Dehui Zhang (1332363)

“…Several OX2R agonists have been reported but with little or no activity at OX1R. We conducted structure–activity relationship studies on the OX2R agonist YNT-185 (<b>2</b>) and discovered dual agonists such as RTOXA-43 (<b>40</b>) with EC₅₀’s of 24 nM at both OX2R and OX1R. …”

Molecular mechanisms responsible KPC-135-mediated resistance to ceftazidime-avibactam in ST11-K47 hypervirulent <i>Klebsiella pneumoniae</i> by Qingyu Shi (10052053)

“…Furthermore, this strain possessed hypervirulent determinants, which included the IncHI1B/FIB plasmid with <i>rmpA2</i> and expression of type 1 and 3 fimbriae. In conclusion, we reported a novel KPC variant, KPC-135, in a clinical ST11-K47 hypervirulent <i>K. pneumoniae</i> strain, which conferred ceftazidime-avibactam resistance, possibly through increased ceftazidime affinity and decreased avibactam susceptibility. …”

Differences in Muscle and Adipose Tissue Gene Expression and Cardio-Metabolic Risk Factors in the Members of Physical Activity Discordant Twin Pairs by Tuija Leskinen (241764)

“…RNA was analyzed with the genome-wide Illumina Human WG-6 v3.0 Expression BeadChip. For pathway analysis we used Gene Set Enrichment Analysis utilizing active vs. inactive co-twin gene expression ratios. …”

Luciferase reporter assay. by Akihito Tsubota (562807)

“…Bars indicate the means of three independent experiments, and the error bars indicate standard deviations. **<i>p</i><0.001 compared with controls.</p>…”

Dynamic behavior of the cross bridges in time. by Lorenzo Marcucci (151628)

“…The traces refer to the isometric contraction, where the lever arm populates its stable positions S0 and S1, but S2 is almost prevented by the high mechanical energy required.…”

NAC and trolox protect ATI-like cells with knocked down Nrf2 against injury induced by CSE. by Beata Kosmider (22264)

“…Data represent results from three independent experiments (<i>p</i><0.05).</p>…”

Data Sheet 1_TP53 and KRAS co-mutations are associated with worse outcomes in mucinous ovarian carcinomas.docx by Yingao Zhang (10690941)

“…On multivariable analysis, TP53/KRAS co-mutations were associated with decreased PFS (adjusted hazard ratio [aHR] 4.02, 95% confidence interval [CI] 1.46-12.5, p=0.01) and OS (aHR 21.4, 95% CI 4.28-156, p<0.001). …”

Relevance of Baseline Viral Genetic Heterogeneity and Host Factors for Treatment Outcome Prediction in Hepatitis C Virus 1b-Infected Patients by Verónica Saludes (236184)

“…We aimed to develop a predictive model of treatment response based on a combination of baseline clinical and viral parameters.…”

MicroRNA-4290 suppresses PDK1-mediated glycolysis to enhance the sensitivity of gastric cancer cell to cisplatin by Yan Qian (388125)

“…Moreover, miR-4290 significantly inhibited glycolysis and decreased the IC50 value to cisplatin in SGC7901 cells, whereas these effects were abolished and cell apoptosis was promoted when PDK1 was overexpressed. …”

Biological processes unaffected by aminoguanidine treatment, histological analyses with thorough pathologist evaluation, and primers used in PCR experiments by CONSUELO PASTEN (22493195)

“…To explore its clinical relevance, we evaluated whether AG could also reduce kidney damage when administered <b>after</b> ischemia. …”

Table_1_Prevalence and associated factors of metabolic-associated fatty liver disease in overweight Finnish children and adolescents.docx by Hanna Riekki (16405338)

“…We investigated the prevalence, risk factors, and metabolic co-morbidities of MAFLD in a large group of overweight children.…”

Image_1_Prevalence and associated factors of metabolic-associated fatty liver disease in overweight Finnish children and adolescents.jpeg by Hanna Riekki (16405338)

“…We investigated the prevalence, risk factors, and metabolic co-morbidities of MAFLD in a large group of overweight children.…”

DataSheet_1_ENSO coupling to the equatorial Atlantic: Analysis with an extended improved recharge oscillator model.pdf by Rodrigo Crespo-Miguel (14422728)

“…Moreover, the damping time of the ENSO fluctuations has doubled from 10 to 20 months, and the oscillation period of ENSO has decreased from 60-70 months before the 1960s to 50 months afterward. …”