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Table_5_NOTCH1 mutation associates with impaired immune response and decreased relapse-free survival in patients with resected T1-2N0 laryngeal cancer.docx
Published 2022“…</p>Results<p>To the best to our knowledge, we present for the first time an overview of the genomic mutation spectrum of early-stage laryngeal cancers. A total of 469 genomic alterations were detected in 211 distinct cancer-relevant genes, and the genes found to be mutated in more than five patients (>10%) included tumor protein p53 (TP53, 78.5%), FAT atypical cadherin 1 (FAT1, 26%), LDL receptor related protein 1B (LRP1B, 19%), cyclin dependent kinase inhibitor 2A (CDKN2A, 17%), tet methylcytosine dioxygenase 2 (TET2, 17%), notch receptor 1 (NOTCH1, 12%) and neuregulin 1 (NRG1, 12%). …”
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Decreasing NR1 and NR2A gene expression in 5-, 14- and 21-day groups.
Published 2017“…<p>All data are presented as the mean ± SEM (n = 8); *** refers to p <0.001 vs. control group. The expression of NR1 <b>(A)</b> and NR2A <b>(B)</b> in the hippocampus of each MMPM group showed a significant decrease compared with the control group.…”
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Cellular stress decreases TDP-43 levels in patient neurons with the TDP-43 A90V mutation.
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