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421
STRUCTURAL AND FUNCTIONAL APPROACHES TOWARD ACTIVITY RESTORATION OF NOVEL CYSTATHIONINE BETA-SYNTHASE MUTATIONS
Published 2024“…Utilizing a multidisciplinary approach, including site-directed mutagenesis and DNA cloning, recombinant protein expression, affinity chromatography purification, circular dichroism spectroscopy, enzymatic assays, and in silico modeling, we assessed the impact of these mutations on CBS stability and function. …”
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422
Calmodulin Mutations Associated with Congenital Cardiac Disease Display Novel Biophysical and Biochemical Characteristics
Published 2018“…In contrast, in the presence of Ca2+, there was a significant decrease in the stability of the five proteins following the order CaMWT> CaMN98I > CaMD132E > CaMQ136P > CaMD134H. …”
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423
Profiling of intestinal microbiota in patients infected with respiratory influenza a and b viruses
Published 2021“…Little is known about the association between respiratory viral infections and their impact on intestinal microbiota. Here, we compared the effect of influenza types, A and B, and influenza shedding in patients’ stools on the gut microbiota diversity and composition. …”
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424
The Role of Qatar Community Pharmacists in Depression care: A Survey of Attitudes, Practices and Perceived Barriers
Published 2020“…Pharmacists' attitudes to depression were moderately positive (mean score=3.41, SD= 0.26). However, the extent of pharmacists' involvement in depression care was very low (mean score=2.64, SD= 0.94). …”
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425
Greensporone C, a Freshwater Fungal Secondary Metabolite Induces Mitochondrial-Mediated Apoptotic Cell Death in Leukemic Cell Lines
Published 2018“…Treatment with GC suppressed constitutively phosphorylated AKT and downregulated expression of inhibitor of apoptotic proteins XIAP, cIAP-1, and cIAP-2. In summation to this, GC-treated leukemic cells upregulated protein expression of pro-apoptotic proteins, Bax with concomitant decrease in expression of anti-apoptotic proteins including Bcl-2 and Bcl-xL. …”
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426
Diabetic Sensorimotor Polyneuropathy Severity Classification Using Adaptive Neuro Fuzzy Inference System
Published 2021“…Diabetic sensorimotor polyneuropathy (DSPN) is an early indicator for non-healing diabetic wounds and diabetic foot ulcers, which account for one of the most common complications of diabetes, leading to increased healthcare cost, decreased quality of life, infections, amputations, and death. …”
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427
Flight Scheduling in the Airspace
Published 2016“…To deal with this problem, we propose a mixed integer programming formulation to find a flight plan that minimizes the objective function, while ensuring the FAA safety standards. …”
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428
Effects of financial turmoil on financial integration and risk premia in emerging markets
Published 2016“…Our sample consists of monthly data for 12 emerging stock markets over the period 1988M3-2015M3. We find that while the financial integration of emerging stock markets has registered short-term reversals episodes in countries that have been exposed to national or/and regional financial crises, it has decreased in most of the emerging countries of our sample since the global crisis. …”
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Glycine and Folate Ameliorate Models of Congenital Sideroblastic Anemia
Published 2016“…Based on these findings, we observed that high levels of exogenous glycine, or 5-aminolevulinic acid (5-Ala) a metabolite downstream of Hem25 in heme biosynthetic pathway, were able to restore heme levels to normal in yeast cells lacking Hem25 function. …”
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433
The Effect of Visual Impairment and Its Severity on Vision-Related and Health-Related Quality of Life in Jordan: A Comparative Cross-Sectional Study
Published 2023“…Glaucoma had a significantly larger reduction in mean scores of all the VFQ-25 subscales, and the PCS of the SF-12 compared to all other ocular diseases. …”
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Ramadan intermittent fasting induced poorer training practices during the COVID-19 lockdown: A global cross-sectional study with 5529 athletes from 110 countries
Published 2022“…Decreases (≥ 5%, p < 0.05) affected more athletes aged 30–39 years than those 18–29 years (60 vs 55%); more national than international athletes (59 vs 51%); more team sports than precision sports (59 vs 46%); more North American than European athletes (62 vs 53%); more semi-professional than professional athletes (60 vs 54%); more athletes who rated their beliefs/attitudes ‘good’ compared to ‘poor’ and ‘moderate’ (61 vs 54 and 53%, respectively); and more athletes with ‘moderate’ than ‘poor’ knowledge (58 vs 53%). …”
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Interface modification of compatibilized polyethylene terephthalate/polypropylene blends: Effect of compatibilization on thermomechanical properties and thermal stability
Published 2015“…Compatibilization with a suitable block/graft copolymer is one way to improve the mechanical and thermal properties of the PET/PP blend. …”
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440